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20-September-2008 09:55:58 - ATP citrate lyase This article or section includes a list of references or external links, but its sources remain unclear because it lacks in-text citations. You can improve this article by introducing more precise citations where appropriate. February 2008 ATP citrate lyase Identifiers Symbol ACLY Entrez 47 HUGO 115 OMIM 108728 RefSeq NM_001096 UniProt P53396 Other data EC number 2.3.3.8 Locus Chr. 17 q21.2 ATP citrate lyase is an enzyme that represents an important step in fatty acid biosynthesis. Contents 1 Reaction 2 Location 3 Structure 4 References Reaction In the presence of ATP and Coenzyme A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and orthophosphate: citrate + ATP + CoA--oxaloacetate + Acetyl-CoA + ADP + Pi. This enzyme was formerly listed as EC 4.1.3.8.1 Location The enzyme is cytosolic in plants2 and animals. Structure The enzyme is composed of two subunits in green plants including Chlorophyceae, Marchantimorpha, Bryopsida, Pinaceae, monocotyledons, and eudicots, species of fungi, Glaucophytes, Chlamydomonas, and prokaryotes. Animal ACL enzymes are homomeric, presumably an evolutionary fusion of the ACLA and ACLB genes probably occurred early in the evolutionary history of this kingdom.3 References ^ MeSH ATP+Citrate+Lyase ^ Kaethner TM, ap Rees T. Planta. 1985;163:290;1 ^ Molecular Characterization of a Heteromeric ATP-Citrate Lyase That Generates Cytosolic Acetyl-Coenzyme A in Arabidopsis - Fatland et al. 130 2: 740 - PLANT PHYSIOLOGY This article incorporates text from the National Library of Medicine, a public domain work of the United States Government. v d e Transferases: acyltransferases EC 2.3 2.3.1: other than amino-acyl groups mostly acetyltransferases N-Acetylglutamate synthase - Choline acetyltransferase - Acetyl-Coenzyme A acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Carnitine O-palmitoyltransferase CPT1, CPT2 - Acyltransferase like 2 - Chloramphenicol acetyltransferase - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase - Histone acetyltransferase P300/CBP - Serotonin N-acetyl transferase - Serine C-palmitoyltransferase SPTLC1, SPTLC2 - HGSNAT 2.3.2 - Aminoacyltransferases Gamma-glutamyl transpeptidase - Peptidyl transferase - Transglutaminase Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII 2.3.3 - converted into alkyl on transfer Citrate synthase - ATP citrate lyase - HMG-CoA synthase v d e Metabolism: lipid metabolism - triglyceride and fatty acid enzymes Lipid production ATP citrate lyase - Acetyl-CoA carboxylase Fatty acid synthesis/Fatty acid synthase: Beta-ketoacyl-ACP synthase - Β-Ketoacyl ACP reductase - 3-Hydroxyacyl ACP dehydrase - Enoyl ACP reductase triacyl glycerol: Glycerol-3-phosphate dehydrogenase - Thiokinase Lipid degradation Acyl transport: Carnitine palmitoyltransferase I - Carnitine-acylcarnitine translocase - Carnitine palmitoyltransferase II Beta oxidation/Mitochondrial trifunctional protein: Acyl CoA dehydrogenase ACADL, ACADM, ACADS, ACADVL - Enoyl-CoA hydratase - 3-Hydroxyacyl CoA dehydrogenase - Acetyl-CoA C-acyltransferase to acetyl-CoA: Malonyl-CoA decarboxylase unsaturated Enoyl CoA isomerase, 2,4 Dienoyl-CoA reductase odd chain Propionyl-CoA carboxylase aldehydes Long-chain-aldehyde dehydrogenase see also disorders Retrieved from http://en..org/wiki/ATP_citrate_lyase Categories: Genes on chromosome 17 | EC 2.3.3 | Citric acid cycleHidden categories: Articles lacking in-text citations | Protein pages needing a picture | articles incorporating text from public domain works of the United States Government Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 30 April 2008, at 03:5
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