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News About Aminophylline

20-September-2008 09:55:55 - Aminophylline Aminophylline Systematic IUPAC name 1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine Identifiers CAS number 317-34-0 ATC code R03DA05 PubChem 9433 DrugBank APRD00329 Chemical data Formula C16H24N10O4 Mol. mass 420.427 g/mol Pharmacokinetic data Bioavailability ? Protein binding 60% Metabolism ? Half life 7-9 hours Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status PUK Routes oral, i.v. Aminophylline is a bronchodilator drug combination that contains theophylline and ethylenediamine in 2:1 ratio. Contents 1 Properties 2 Mechanism of action 3 Brand names 4 References Properties It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether. Mechanism of action Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma. Causes bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenine monophosphate cAMP which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis and induces release of epinephrine from adrenal medulla cells Brand names Phyllocontin Truphylline References July 2008 v d e Drugs for obstructive airway diseases: asthma/COPD R03 Adrenergics, inhalants Short acting β2-agonists Salbutamol/Levosalbutamol Fenoterol Terbutaline Pirbuterol Procaterol Bitolterol Rimiterol Carbuterol Tulobuterol Reproterol Long acting β2-agonists LABA Arformoterol Bambuterol Clenbuterol Formoterol Salmeterol Ultra LABA: Indacaterol other Epinephrine Hexoprenaline Isoprenaline Isoproterenol Orciprenaline Metaproterenol Glucocorticoids Beclometasone Budesonide Ciclesonide Fluticasone Mometasone Anticholinergics/ muscarinic antagonist Ipratropium Tiotropium Mast cell stabilizers Cromoglicate Nedocromil Xanthines Aminophylline Doxofylline Theobromine Theophylline Leukotriene antagonists Montelukast Pranlukast Zafirlukast Lipoxygenase inhibitor Zileuton Thromboxane receptor antagonists Ramatroban Seratrodast Combination products Budesonide/formoterol Fluticasone/salmeterol Ipratropium/salbutamol Retrieved from http://en..org/wiki/Aminophylline Categories: Bronchodilators | XanthinesHidden categories: Articles lacking sources from July 2008 | All articles lacking sources Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch 日本語 Polski Português РуÑ?Ñ?кий This page was last modified on 12 July 2008, at 15:53

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