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20-September-2008 09:55:47 - Sympatholytic Redirected from Antiadrenergic A sympatholytic drug is a medication which inhibits the postganglionic functioning of the sympathetic nervous system SNS.1 Though some are indicated for various functions, they can all be used as antihypertensives. Contents 1 Antiadrenergic 1.1 In hypertension 2 References 3 External links Antiadrenergic Antiadrenergic agents inhibit the signals of epinephrine and norepinephrine. They are primarily adrenergic antagonists, inhibiting adrenergic receptors, but there are exceptions: clonidine is an adrenergic agonist on the α2 receptor, since this receptor is located presynaptically to inhibit further release of adrenaline and noradrenaline. Other ways of inhibiting adrenergic signaling is by catecholamine synthesis blocking, e.g. by methyltyrosine. Reserpine works by inhibiting transport into synaptic vesicles of noradrenaline by inhibiting the VMAT transporter. In hypertension Many antiadrenergic agents used as antihypertensives include: centrally acting: Clonidine α2 agonist Guanfacine α2 agonist Methyldopa α2 agonist Moxonidine imidazoline receptor agonist Rescinnamine ACE inhibitor Reserpine VMAT inhibitor Rilmenidine imidazoline receptor agonist ganglion-blocking Mecamylamine α3β4 nicotinic receptor inhibitor Trimethaphan ganglion type receptor inhibitor peripherally acting Prazosin α1 antagonist Guanethidine Magnesium-ATPase inhibitor Indoramin α1 antagonist Doxazosin alpha blocker References ^ Dorlands Medical Dictionary:sympatholytic. External links MeSH Sympatholytics v d e Receptor agonists, antagonists, and reuptake inhibitors BA/M 5-HT serotonin receptor Serotonin receptor agonist 5-HT4 Serotonin antagonist 5-HT3 Serotonin uptake inhibitor SSRI Dopamine receptor Dopamine agonist Dopamine antagonist Dopamine reuptake inhibitor Adrenergic receptor Adrenergic agonist Alpha, Beta 1/2 Adrenergic antagonist Alpha 1/2, Beta Adrenergic uptake inhibitor Histamine receptor Histamine agonist Histamine antagonist H1, H2, H3 AA GABA receptor GABA agonist GABA antagonist Glutamate receptor NMDA receptor NMDA receptor antagonist AMPA receptor Ampakine Excitatory amino acid agonist Excitatory amino acid antagonist ANS Acetylcholine receptor Cholinergic Muscarinic, Nicotinic Anticholinergic Muscarinic, Nicotinic/Ganglionic blocker/Neuromuscular-blocking drugs Acetylcholinesterase inhibitor Adrenergic receptor SANS only -- see above for details PANS Parasympathomimetic Cholinergic, Acetylcholinesterase inhibitor - Parasympatholytic Anticholinergic, Ganglionic blocker SANS Sympathomimetic Adrenergic agonist, Monoamine oxidase inhibitor - Sympatholytic Adrenergic antagonist, Alpha blocker, Ganglionic blocker v d e Antihypertensives C02 and diuretics C03 Sympatholytic agents Centrally acting/antiadrenergics α2 agonist Clonidine, Guanfacine, Methyldopa imidazoline receptor agonist Moxonidine, Rilmenidine adrenergic uptake inhibitor Rescinnamine, Reserpine Ganglion-blocking/nicotinic antagonist Mecamylamine, Trimethaphan Peripherally acting/antiadrenergics α1 blockers: Prazosin Indoramin Trimazosin Doxazosin Urapidil Guanidine derivatives: Betanidine Guanethidine Guanoxan Debrisoquine Guanoclor Guanazodine Guanoxabenz Vasodilators Diazoxide hydrazinophthalazine Hydralazine, Dihydralazine, Endralazine, Cadralazine Minoxidil Nitroprusside Phentolamine Other antihypertensives serotonin antagonist Ketanserin endothelin receptor antagonist Bosentan, Ambrisentan, Sitaxsentan MAOI Pargyline THI Metirosine Diuretics Low ceiling Thiazides at DCT Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Chlorothiazide Polythiazide Trichlormethiazide Cyclopenthiazide Methyclothiazide Cyclothiazide Mebutizide Sulfonamides Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone Other Mersalyl Theobromine Cicletanine osmotic Mannitol, Urea carbonic anhydrase inhibitor at PT Acetazolamide High ceiling Loop diuretic at AL Bumetanide, Furosemide, Torasemide, Ethacrynic acid Potassium-sparing at CD ESC blockers Amiloride, Triamterene aldosterone antagonists Spironolactone, Eplerenone, Potassium canrenoate, Canrenone Tablets This pharmacology-related article is a stub. Retrieved from http://en..org/wiki/Sympatholytic#Antiadrenergic Categories: Pharmacology stubs | Antihypertensive agents Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Português This page was last modified on 10 August 2008, at 01:4
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