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20-September-2008 09:55:57 - Azelastine Azelastine Systematic IUPAC name 4-4-chlorophenylmethyl-2- 1-methylazepan-4-yl-phthalazin-1-one Identifiers CAS number 58581-89-8 ATC code R01AC03 R06AX19, S01GX07 PubChem 2267 DrugBank APRD00813 Chemical data Formula C22H24ClN3O Mol. mass 381.898 g/mol Pharmacokinetic data Bioavailability 40% intranasal Metabolism ? Half life 22 hours Excretion ? Therapeutic considerations Pregnancy cat. CUS Legal status Routes intranasal, ocular Azelastine is an antihistamine and mast cell stabilizer available as a nasal spray Astelin for hay fever and as eye drops Optivar for allergic conjunctivitis. It is very useful to help with seasonal allergies becauses of its medical properties Contents 1 Side effects 1.1 Nasal spray 2 External links 3 References Side effects Nasal spray Side effects of azelastine nasal spray vary somewhat depending on the condition being treated. The most common side effects include bitter taste, headache, rhinitis, nose bleed, and somnolence. Adults being treated for vasomotor rhinitis may also experience dysesthesia and sinusitis. Additional side effects experienced by adults being treated for seasonal allergies include nasal burning, pharyngitis, dry mouth, paroxysmal sneezing, nausea, fatigue, dizziness, and weight gain.1 External links Official Astelin Website Official Optivar Website Manufacturer's Website References ^ Astelin prescribing information v d e Decongestants and other nasal preparations R01 Topical Sympathomimetics, plain Cyclopentamine - Ephedrine - Phenylephrine - Oxymetazoline - Tetryzoline - Xylometazoline - Naphazoline - Tramazoline - Metizoline - Tuaminoheptane - Fenoxazoline - Tymazoline - Epinephrine Antiallergic agents, excluding corticosteroids Spaglumic acid histamine antagonists Levocabastine, Antazoline, Thonzylamine mast cell stabilizer some are also antihistamines Cromoglicic acid, Nedocromil, Azelastine, Olopatadine Corticosteroids Beclometasone - Prednisolone - Dexamethasone - Flunisolide - Budesonide - Betamethasone - Tixocortol - Fluticasone - Mometasone furoate - Triamcinolone - Ciclesonide Other nasal preparations Calcium hexamine thiocyanate - Retinol - Ipratropium bromide - Ritiometan - Mupirocin - Hexamidine - Framycetin Systemic use: Sympathomimetics Phenylpropanolamine - Pseudoephedrine - Phenylephrine v d e Histamine antagonists H1 or non-selective Alkylamines Bepotastine Bamipine Brompheniramine Chlorpheniramine Dexbrompheniramine Dexchlorpheniramine Dimethindene Metron S Pheniramine Pyrrobutamine Talastine Thenaldine Tolpropamine Triprolidine Ethanolamines Aminoalkyl ethers Bietanautine Bromazine/Bromodiphenhydramine Carbinoxamine Chlorphenoxamine Clemastine Diphenylpyraline Diphenhydramine Doxylamine Embramine p-Methyldiphenhydramine Moxastine Orphenadrine Phenyltoloxamine Setastine Ethylenediamines Chloropyramine Chlorothen Histapyrrodine Methafurylene Mepyramine Methapyrilene Pyrilamine Talastine Thenyldiamine Thonzylamine Tripelennamine Pyribenzamine Phenothiazine Tricyclics Ahistan Etymemazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Thiazinamium Other Tricyclics Azatadine Clobenzepam Cyproheptadine Deptropine Isothipendyl Loratidine Piperazine Buclizine Chlorcyclizine Cinnarizine Clocinizine Hydroxyzine Niaprazine Oxatomide Benzhydryl compounds Cyclizine, Meclizine Others including selective, 2nd gen, 3rd gen Antazoline Astemizole Azatadine Azelastine Bepottastine Bamipine Cetoxine Clemizole Clobenztropine Deptropine Desloratadine Dimebon Ebastine Emedastine Epinastine Ketotifen Levocabastine Loratadine Mebhydrolin Mizolastine Phenindamine Pimethixene Pyrrobutamine Rupatadine Thenalidine Tritoqualine Alkylamine Acrivastine Tricyclic Olopatadine Piperazine Levocetirizine, Cetirizine Benzhydryl compounds Fexofenadine, Terfenadine H2 Cimetidine Famotidine Ranitidine Roxatidine Lafutidine Niperotidine Nizatidine H3 A-349,821 ABT-239 Burimamide Ciproxifan Clobenpropit Conessine Impentamine Iodophenpropit Thioperamide VUF-5681 H4 JNJ 7777120 Thioperamide VUF-6002 This molecular or cell biology article is a stub. Tablets This pharmacology-related article is a stub. Retrieved from http://en..org/wiki/Azelastine Categories: Antihistamines | Molecular and cellular biology stubs | Pharmacology stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Polski This page was last modified on 21 May 2008, at 00:53
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