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20-September-2008 09:55:47 - Bumetanide Bumetanide Systematic IUPAC name 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid Identifiers CAS number 28395-03-1 ATC code C03CA02 PubChem 2471 DrugBank APRD00294 Chemical data Formula C17H20N2O5S Mol. mass 364.417 g/mol SMILES eMolecules PubChem Pharmacokinetic data Bioavailability almost complete Protein binding 97% Metabolism hepatic Half life 60-90 minutes Excretion renal Therapeutic considerations Pregnancy cat. B3AU CUS Legal status Prescription Only S4AU POMUK ℞-onlyUS Routes oral Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche with the brand name Bumex. The main difference between the two substances is in bioavailability. Furosemide is incompletely absorbed in the intestine 40%, and there is substantial inter- and intraindividual differences in bioavailability range 10-90%. Bumetanide is completely absorbed 80%, and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect. Bumetanide is 40 times more potent than furosemide for patients with normal renal function. External links Bumex manufacturer's website Bumetanide patient information Tablets This pharmacology-related article is a stub. v d e Membrane transport modulators Calcium channel blockers Amlodipine Amrinone Anandamide Anipamil Azimilide Bencyclane Benidipine Bepridil Berbamine Bevantolol Canadine Carboxyamido-Triazole Cilnidipine Cinnarizine Clentiazem Conotoxins Darodipine Dauricine Devapamil Diltiazem Dimiapramine Dotarizine Efonidipine Emopamil Enpiperate Eperisone Falipamil Fantofarone Fasudil Felodipine Fenamic acid Fendiline Flunarizine Fosfedil Gabapentin Gallopamil Isradipine Lacidipine Lamotrigine Lercanidipine Lidoflazine Magnesium sulfate Manidipine Manoalide Mepirodipine Mibefradil Monatepil Naftopidil Nicardipine Nifedipine Niguldipine Niludipin Nilvadipine Nimodipine Nisoldipine Nitrendipine Norverapamil Ochratoxin A Octylonium Osthol Oxodipine Perhexiline Pinaverium Piperidine Pranidipine Prenylamine Risedronic acid Ryodipine Sesamodil Stepholidine Terodiline Tetrahydropalmatine Tetrandrine Tolfenamic acid Tranilast Verapamil Potassium channel blockers 3,4-Diaminopyridine 4-Aminopyridine Dofetilide Linopirdine Paxilline Tetraethylammonium Sodium channel blockers Amiloride Encainide Pilsicainide Tetrodotoxin Tocainide Sodium chloride symporter inhibitors Bendroflumethiazide Chlorothiazide Chlorthalidone Cyclopenthiazide Hydrochlorothiazide Hydroflumethiazide Methyclothiazide Polythiazide Trichlormethiazide Sodium potassium chloride symporter inhibitors Bumetanide Furosemide v d e Antihypertensives C02 and diuretics C03 Sympatholytic agents Centrally acting/antiadrenergics α2 agonist Clonidine, Guanfacine, Methyldopa imidazoline receptor agonist Moxonidine, Rilmenidine adrenergic uptake inhibitor Rescinnamine, Reserpine Ganglion-blocking/nicotinic antagonist Mecamylamine, Trimethaphan Peripherally acting/antiadrenergics α1 blockers: Prazosin Indoramin Trimazosin Doxazosin Urapidil Guanidine derivatives: Betanidine Guanethidine Guanoxan Debrisoquine Guanoclor Guanazodine Guanoxabenz Vasodilators Diazoxide hydrazinophthalazine Hydralazine, Dihydralazine, Endralazine, Cadralazine Minoxidil Nitroprusside Phentolamine Other antihypertensives serotonin antagonist Ketanserin endothelin receptor antagonist Bosentan, Ambrisentan, Sitaxsentan MAOI Pargyline THI Metirosine Diuretics Low ceiling Thiazides at DCT Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Chlorothiazide Polythiazide Trichlormethiazide Cyclopenthiazide Methyclothiazide Cyclothiazide Mebutizide Sulfonamides Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone Other Mersalyl Theobromine Cicletanine osmotic Mannitol, Urea carbonic anhydrase inhibitor at PT Acetazolamide High ceiling Loop diuretic at AL Bumetanide, Furosemide, Torasemide, Ethacrynic acid Potassium-sparing at CD ESC blockers Amiloride, Triamterene aldosterone antagonists Spironolactone, Eplerenone, Potassium canrenoate, Canrenone Retrieved from http://en..org/wiki/Bumetanide Categories: Pharmacology stubs | Loop diuretics Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Español Italiano ไทย This page was last modified on 1 August 2008, at 02:42
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