Sierra Acai Company
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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 09:55:50 - Carbidopa Carbidopa Systematic IUPAC name 2S-3-3,4-dihydroxyphenyl-2-hydrazinyl-2-methyl- propanoic acid Identifiers CAS number 28860-95-9 ATC code ? PubChem 34359 DrugBank APRD00160 Chemical data Formula C10H14N2O4 Mol. mass 226.229 g/mol Pharmacokinetic data Bioavailability ? Protein binding 76% Metabolism decarboxylated to dopamine in extracerebral tissues Half life 2 hours Excretion ? Therapeutic considerations Licence data US Pregnancy cat. ? Legal status POMUK Routes ? Carbidopa MK-486, tradename Lodosyn is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism of levodopa. Carbidopa inhibits aromatic-L-amino-acid decarboxylase DOPA Decarboxylase or DDC, an enzyme important in the biosynthesis of L-tryptophan to serotonin and in the biosynthesis of L-DOPA to Dopamine DA. Along with carbidopa, other DDC inhibitors are benserazide Ro-4-4602, difluromethyldopa, and α-methyldopa. Used in tandem with L-DOPA trade name levodopa, a dopamine precursor converted in the body to dopamine, it increases the plasma half-life of levodopa from 50 minutes to 1 1/2 hours. CarbiDOPA cannot cross the blood brain barrier, so it inhibits only peripheral DDC. It thus prevents the conversion of L-DOPA to dopamine peripherally. This reduces the side effects caused by dopamine on the periphery, as well as increasing the concentration of L-DOPA and dopamine in the brain. The combination of carbidopa/levodopa carries the brand names of Sinemet, Parcopa and Atamet; whilst Stalevo is a combination with entacapone, which enhances the bioavailability of carbidopa and levodopa. Carbidopa is also used in combination with 5-HTP, a naturally-occurring amino acid which is a precursor to the neurotransmitter serotonin and an intermediate in tryptophan metabolism. Carbidopa prevents 5-HTP's metabolism in the liver, which can lead to elevated levels of serotonin in the bloodstream. Research shows that co-administration of 5-HTP and carbidopa greatly increases plasma 5-HTP levels. External links Lodosyn prescribing information Sinemet datasheet for New Zealand v d e Anti-parkinson drugs: dopaminergic agents N04B Dopa and derivatives Droxidopa Levodopa Melevodopa Etilevodopa Adamantane derivatives Amantadine Dopamine agonists A-412,997 Apomorphine Bromocriptine Cabergoline Dihydrexidine Dihydroergocryptine mesylate Fenoldopam Lisuride Pergolide Piribedil Pramipexole Propylnorapomorphine Quinpirole Ropinirole Rotigotine SKF 38393 SKF 82958 MAOIs B Selegiline Rasagiline COMT inhibitors Entacapone Tolcapone Other Budipine dopa decarboxylase inhibitor Carbidopa Retrieved from http://en..org/wiki/Carbidopa Categories: Antiparkinsonian agents Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Italiano This page was last modified on 10 July 2008, at 15:13
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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