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News About Carboxypeptidase_A

20-September-2008 09:55:59 - Carboxypeptidase A Carboxypeptidase A, from bovine pancreas Carboxypeptidase A, from bovine pancreas Carboxypeptidase A usually refers to the pancreatic exopeptidase which hydrolyzes peptide bonds of C-terminal residues with aromatic or aliphatic side chains. Most scientists in the field now refer to this enzyme as CPA1, and to a related pancreatic carboxypeptidase as CPA2. In addition, there are 4 other mammalian enzymes named CPA-3 through CPA-6, and none of these are expressed in the pancreas. Instead, these other CPA-like enzymes have diverse functions. CPA3 also known as mast-cell CPA is involved in the digestion of proteins by mast cells. CPA4 previously known as CPA-3, but renumbered when mast-cell CPA was designated CPA-3 may be involved in tumor progression, but this enzyme has not been well studied. CPA5 and CPA6 have also not been well studied. Interestingly, a human mutation of CPA-6 is known to cause Duane's syndrome abnormal eye movement. This, together with the localization of CPA-6 to embryonic eye muscle in addition to other limited locations suggests a role for CPA-6 in the control of neuronal migration/axonal guidance. CPA-1 and CPA-2 and presumably all other CPAs contain a zinc atom at the active site. Loss of the zinc leads to loss of activity, which can be replaced easily by zinc, and also by some other divalent metals cobalt, nickel. External links MeSH Carboxypeptidases+A v d e Hydrolase: proteases EC 3.4 Exopeptidase 3.4.11-19 Angiotensin-converting enzyme - Dipeptidase - Dipeptidyl peptidase-4 - DD-transpeptidase Metalloexopeptidases: Aminopeptidase Alanine, Cystinyl, Leucyl, Glutamyl - Carboxypeptidase A, B, C, E, Glutamate II Endopeptidase 3.4.21-24 Serine proteases - Cysteine protease - Aspartic acid protease - Metalloendopeptidases Cathepsin 3.4.18,21,22,23 A - B - C - D - E - F - G - H - K - L1/L2 - S - W - Z Retrieved from http://en..org/wiki/Carboxypeptidase_A Categories: Proteins | Enzymes | Metabolism Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 23 November 2007, at 22:40

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