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20-September-2008 09:55:58 - I carnitine palmitoyltransferase 1A liver Identifiers Symbol CPT1A Alt. Symbols CPT1 Entrez 1374 HUGO 2328 OMIM 600528 RefSeq NM_001876 UniProt P50416 Other data EC number 2.3.1.21 Locus Chr. 11 q13.1-13.5 carnitine palmitoyltransferase 1B muscle Identifiers Symbol CPT1B Entrez 1375 HUGO 2329 OMIM 601987 RefSeq NM_152245 UniProt Q92523 Other data Locus Chr. 22 q13.3 carnitine palmitoyltransferase 1C Identifiers Symbol CPT1C Entrez 126129 HUGO 18540 OMIM 608846 RefSeq NM_152359 UniProt Q8TCG5 Other data Locus Chr. 19 q13.33 Carnitine palmitoyltransferase I CPT1is a mitochondrial enzyme. In muscle and other non-liver tissues, CPT1 is associated with the outer mitochondrial membrane. CPT1 mediates the transport of long chain fatty acids across the membrane by binding them to carnitine. This enzyme can be inhibited by malonyl CoA. The CPT1A form is associated with carnitine palmitoyltransferase I deficiency. Acyl-CoA from cytosol to the mitochondrial matrix.gif Acyl-CoA from cytosol to the mitochondrial matrix.gif See also Carnitine palmitoyltransferase II This transferase article is a stub. v d e Transferases: acyltransferases EC 2.3 2.3.1: other than amino-acyl groups mostly acetyltransferases N-Acetylglutamate synthase - Choline acetyltransferase - Acetyl-Coenzyme A acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Carnitine O-palmitoyltransferase CPT1, CPT2 - Acyltransferase like 2 - Chloramphenicol acetyltransferase - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase - Histone acetyltransferase P300/CBP - Serotonin N-acetyl transferase - Serine C-palmitoyltransferase SPTLC1, SPTLC2 - HGSNAT 2.3.2 - Aminoacyltransferases Gamma-glutamyl transpeptidase - Peptidyl transferase - Transglutaminase Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII 2.3.3 - converted into alkyl on transfer Citrate synthase - ATP citrate lyase - HMG-CoA synthase v d e Mitochondrial enzymes and transporters Outer membrane fatty acid degradation Carnitine palmitoyltransferase I, Long fatty acyl CoA synthetase tryptophan metabolism Kynureninase monoamine neurotransmitter metabolism Monoamine oxidase Intermembrane space Adenylate kinase - Creatine kinase Inner membrane oxidative phosphorylation Coenzyme Q - cytochrome c reductase, Cytochrome c, NADH dehydrogenase, Succinate dehydrogenase pyrimidine metabolism Dihydroorotate dehydrogenase mitochondrial shuttle Malate-aspartate shuttle, Glycerol phosphate shuttle other Glutamate aspartate transporter, Glycerol-3-phosphate dehydrogenase, ATP synthase, Carnitine palmitoyltransferase II Matrix citric acid cycle Citrate synthase, Aconitase, Isocitrate dehydrogenase, Oxoglutarate dehydrogenase, Succinyl coenzyme A synthetase, Fumarase, Malate dehydrogenase anaplerotic reactions Aspartate transaminase, Glutamate dehydrogenase, Pyruvate dehydrogenase complex urea cycle Carbamoyl phosphate synthetase I, Ornithine transcarbamylase, N-Acetylglutamate synthase alcohol metabolism ALDH2 Other/to be sorted Cholesterol side-chain cleavage enzyme Mitochondrial DNA Complex I 7 units - Complex III 1 unit - Complex IV 3 units - ATP synthase 2 units Retrieved from http://en..org/wiki/Carnitine_palmitoyltransferase_I Categories: Genes on chromosome 11 | Genes on chromosome 22 | Genes on chromosome 19 | Transferase stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages EspaƱol This page was last modified on 31 May 2008, at 12:51
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