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20-September-2008 09:55:52 - component 4 Redirected from Chido-Rodgers antigen system Jump to: navigation, search complement component 4A Rodgers blood group Identifiers Symbol C4A Entrez 720 HUGO 1323 OMIM 120810 RefSeq NM_007293 UniProt P0C0L4 Other data Locus Chr. 6 p21.3 complement component 4B Childo blood group Identifiers Symbol C4B Entrez 721 HUGO 1324 OMIM 120820 RefSeq NM_000592 UniProt P0C0L5 Other data Locus Chr. 6 p21.3 Complement component 4 is a protein involved in the complement system. It is cleaved into proteins 4a and 4b. C4a is an anaphylatoxin. C4b forms part of C3-convertase, in conjunction with 2a: C4b can bind CR1. Classical pathway. Some labels are in Polish. Classical pathway. Some labels are in Polish. Clinical significance It is responsible for the Chido Rodgers blood group system.1 C4d has been identified as a biomarker for systemic lupus erythematosus.2 References ^ Chido Rodgers blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ^ Liu CC, Manzi S, Kao AH, Navratil JS, Ruffing MJ, Ahearn JM 2005. Reticulocytes bearing C4d as biomarkers of disease activity for systemic lupus erythematosus. Arthritis Rheum. 52 10: 3087-99. doi:10.1002/art.21305. PMID 16200588. v d e Proteins: complement system C, L, A Activators CLA: C3-convertase - C5-convertase - MAC C6, C7, C8, C9 - L: Mannan-binding lectin - A: Factor P/Properdin Enzymes C: C1Q/C1R/C1S - C4 C4a - C2 - CLA: C3 C3a, C3b/iC3b - C5 C5a - L: MASP1 - MASP2 - A: Complement factor B - Factor D Inhibitors CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H Complement receptors CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin C3a, C5a Retrieved from http://en..org/wiki/Complement_component_4 Categories: Genes on chromosome 6 | Blood | Hematology | Transfusion medicine | Blood antigen systems | Complement systemHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 18 July 2008, at 12:53
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