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20-September-2008 09:55:47 - Chlorothiazide Chlorothiazide Systematic IUPAC name 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide Identifiers CAS number 58-94-6 ATC code C03AA04 PubChem 2720 DrugBank APRD00721 Chemical data Formula C7H6ClN3O4S2 Mol. mass 295.725 g/mol Pharmacokinetic data Bioavailability ? Metabolism Nil Half life 45 to 120 minutes Excretion Renal Therapeutic considerations Pregnancy cat. CUS Legal status ℞-onlyUS Routes Oral Chlorothiazide sodium Diuril is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide Lasix. Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube NG tube, the two drugs potentiate one another without risk of toxicity. Because it is absorbed enterically there are no risks associated with chlorothiazide as there are with furosemide administration. Contents 1 Indications 2 Contraindications 3 Dose 4 Side effects Indications Large amount of excess fluid including: Diagnosed congested heart failure Peripheral edema Rales / Rhonchi Hypertension Contraindications Renal failure or insufficency Allergies to sulfa drugs Dose 500 mg-1 g once or twice a day, by mouth or through NG tube reconstituted suspension May also be given intravenously, and should be given first if given in combination with IV lasix since it potentiate's the diuretic effect of furosemide. Side effects Nausea / Vomiting Headache Dizziness Excess urine production Dehydration Hypoelectrolytemia esp. hypokalemia / hypomagnesia v d e Membrane transport modulators Calcium channel blockers Amlodipine Amrinone Anandamide Anipamil Azimilide Bencyclane Benidipine Bepridil Berbamine Bevantolol Canadine Carboxyamido-Triazole Cilnidipine Cinnarizine Clentiazem Conotoxins Darodipine Dauricine Devapamil Diltiazem Dimiapramine Dotarizine Efonidipine Emopamil Enpiperate Eperisone Falipamil Fantofarone Fasudil Felodipine Fenamic acid Fendiline Flunarizine Fosfedil Gabapentin Gallopamil Isradipine Lacidipine Lamotrigine Lercanidipine Lidoflazine Magnesium sulfate Manidipine Manoalide Mepirodipine Mibefradil Monatepil Naftopidil Nicardipine Nifedipine Niguldipine Niludipin Nilvadipine Nimodipine Nisoldipine Nitrendipine Norverapamil Ochratoxin A Octylonium Osthol Oxodipine Perhexiline Pinaverium Piperidine Pranidipine Prenylamine Risedronic acid Ryodipine Sesamodil Stepholidine Terodiline Tetrahydropalmatine Tetrandrine Tolfenamic acid Tranilast Verapamil Potassium channel blockers 3,4-Diaminopyridine 4-Aminopyridine Dofetilide Linopirdine Paxilline Tetraethylammonium Sodium channel blockers Amiloride Encainide Pilsicainide Tetrodotoxin Tocainide Sodium chloride symporter inhibitors Bendroflumethiazide Chlorothiazide Chlorthalidone Cyclopenthiazide Hydrochlorothiazide Hydroflumethiazide Methyclothiazide Polythiazide Trichlormethiazide Sodium potassium chloride symporter inhibitors Bumetanide Furosemide v d e Antihypertensives C02 and diuretics C03 Sympatholytic agents Centrally acting/antiadrenergics α2 agonist Clonidine, Guanfacine, Methyldopa imidazoline receptor agonist Moxonidine, Rilmenidine adrenergic uptake inhibitor Rescinnamine, Reserpine Ganglion-blocking/nicotinic antagonist Mecamylamine, Trimethaphan Peripherally acting/antiadrenergics α1 blockers: Prazosin Indoramin Trimazosin Doxazosin Urapidil Guanidine derivatives: Betanidine Guanethidine Guanoxan Debrisoquine Guanoclor Guanazodine Guanoxabenz Vasodilators Diazoxide hydrazinophthalazine Hydralazine, Dihydralazine, Endralazine, Cadralazine Minoxidil Nitroprusside Phentolamine Other antihypertensives serotonin antagonist Ketanserin endothelin receptor antagonist Bosentan, Ambrisentan, Sitaxsentan MAOI Pargyline THI Metirosine Diuretics Low ceiling Thiazides at DCT Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Chlorothiazide Polythiazide Trichlormethiazide Cyclopenthiazide Methyclothiazide Cyclothiazide Mebutizide Sulfonamides Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone Other Mersalyl Theobromine Cicletanine osmotic Mannitol, Urea carbonic anhydrase inhibitor at PT Acetazolamide High ceiling Loop diuretic at AL Bumetanide, Furosemide, Torasemide, Ethacrynic acid Potassium-sparing at CD ESC blockers Amiloride, Triamterene aldosterone antagonists Spironolactone, Eplerenone, Potassium canrenoate, Canrenone Retrieved from http://en..org/wiki/Chlorothiazide Categories: Thiazides Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages 日本語 Nederlands This page was last modified on 1 August 2008, at 02:39
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