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20-September-2008 09:55:55 - Cocaethylene Cocaethylene Systematic IUPAC name ethyl 2R,3S-3-benzoyloxy-8-methyl-8-azabicyclo3.2.1octane-2-carboxylate Identifiers CAS number 529-38-4 ATC code ? PubChem 65034 Chemical data Formula C18H23NO4 Mol. mass 317.38 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes from prodrugs cocaine and ethanol Cocaethylene is the ethyl ester of benzoylecgonine. It is chemically related to cocaine, which is the corresponding methyl ester. Cocaethylene is formed in the body when cocaine and alcohol have been taken simultaneously: the transesterification is catalysed by carboxylesterases in the liver. It does not occur naturally in coca leaves. Cocaethylene produces a more euphoric stimulation than cocaine in most users, and is longer lasting in the body. Some studies suggest that it may have a higher cardiovascular toxicity than cocaine. Cocaethylene however is less potent at binding to serotonin norepinephrine transporters than cocaine is.1 References ^ 1 2 M. J. Landry, J. Psychoactive Drugs 1992, 24, 273-6. M. Perez et al., Psychopharmacology Berl. 1994, 116, 428-32., M. J. Landry, Behavioral Health Management 1994, September 1. S. C. Laizure et al., Drug Metabolism Disposition 2003, 31, 16-20. See also Vin Mariani Ethylphenidate External links Tablets This pharmacology-related article is a stub. Retrieved from http://en..org/wiki/Cocaethylene Categories: Pharmacology stubs | Benzoates | Carboxylate esters | Tropanes Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Norsk bokmål This page was last modified on 28 April 2008, at 06:23
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