Sierra Acai Company
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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 09:55:57 - Cyclizine Cyclizine Systematic IUPAC name 1-benzhydryl-4-methyl-piperazine Identifiers CAS number 82-92-8 ATC code R06AE03 PubChem 6726 DrugBank APRD00061 Chemical data Formula C18H22N2 Mol. mass 266.381 g/mol SMILES eMolecules PubChem Pharmacokinetic data Bioavailability ? Metabolism N-demethylated to inactive norcyclizine Half life 20 hours Excretion ? Therapeutic considerations Pregnancy cat. A Au Legal status P/POM UK OTC NL Routes Oral, IM, IV Cyclizine is an antihistamine drug used to treat nausea, vomiting and dizziness associated with motion sickness, vertigo and post-operative following administration of general anaesthesia and opioids. Contents 1 Pharmacology 2 Contraindications 3 Side effects 4 Formulations 5 References Pharmacology Cyclizine is a piperazine derivative with histamine H1-receptor antagonist antihistamine activity. The precise mechanism of action in inhibiting the symptoms of motion sickness is not well understood. It may have effects directly on the labyrinthine apparatus and on the chemoreceptor trigger zone. Cyclizine exerts a central anticholinergic antimuscarinic action. Contraindications Its antimuscarinic action warrants caution in patients with prostatic hypertrophy, urinary retention, glaucoma. Liver disease exacerbates its sedative effects. It cannot be combined with diclofenac, for example in the same syringe or bag of fluids, as a crystallisation reaction occurs. Some opiate-dependent patients combine cyclizine with their methadone dosage, a combination that is known to produce strong psychoactive effects1. It is also sold in combination with another opioid dipipanone under the brand name Diconal.2 Side effects Common 10% - Drowsiness, xerostomia dry mouth Uncommon 1% to 10% - Headache, psychomotor impairment, and antimuscarinic effects such as urinary retention, diplopia blurred vision, dermatitis, and gastro-intestinal disturbances. Rare - Hypersensitivity reactions bronchospasm, angioedema, anaphylaxis, rashes and photosensitivity reactions, extrapyramidal effects, dizziness, confusion, depression, sleep disturbances, tremor, liver dysfunction. Formulations As cyclizine hydrochloride 50mg tablets and cyclizine lactate solution for intramuscular or intravenous injection Brand names: Valoid in UK and Marezine, Marzine and Emoquil in US. References British National Formulary 53 2007 Lexi-Online drug database http://online.lexi.com/crlsql/servlet/crlonline ^ Cyclizine Abuse among a Group of Opiate Dependents Receiving Methadone, Addiction 84 8, 929-934 ^ Diconal Tablets by Amdipharm. Electronic Medicines Compendium. v d e Histamine antagonists H1 or non-selective Alkylamines Bepotastine Bamipine Brompheniramine Chlorpheniramine Dexbrompheniramine Dexchlorpheniramine Dimethindene Metron S Pheniramine Pyrrobutamine Talastine Thenaldine Tolpropamine Triprolidine Ethanolamines Aminoalkyl ethers Bietanautine Bromazine/Bromodiphenhydramine Carbinoxamine Chlorphenoxamine Clemastine Diphenylpyraline Diphenhydramine Doxylamine Embramine p-Methyldiphenhydramine Moxastine Orphenadrine Phenyltoloxamine Setastine Ethylenediamines Chloropyramine Chlorothen Histapyrrodine Methafurylene Mepyramine Methapyrilene Pyrilamine Talastine Thenyldiamine Thonzylamine Tripelennamine Pyribenzamine Phenothiazine Tricyclics Ahistan Etymemazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Thiazinamium Other Tricyclics Azatadine Clobenzepam Cyproheptadine Deptropine Isothipendyl Loratidine Piperazine Buclizine Chlorcyclizine Cinnarizine Clocinizine Hydroxyzine Niaprazine Oxatomide Benzhydryl compounds Cyclizine, Meclizine Others including selective, 2nd gen, 3rd gen Antazoline Astemizole Azatadine Azelastine Bepottastine Bamipine Cetoxine Clemizole Clobenztropine Deptropine Desloratadine Dimebon Ebastine Emedastine Epinastine Ketotifen Levocabastine Loratadine Mebhydrolin Mizolastine Phenindamine Pimethixene Pyrrobutamine Rupatadine Thenalidine Tritoqualine Alkylamine Acrivastine Tricyclic Olopatadine Piperazine Levocetirizine, Cetirizine Benzhydryl compounds Fexofenadine, Terfenadine H2 Cimetidine Famotidine Ranitidine Roxatidine Lafutidine Niperotidine Nizatidine H3 A-349,821 ABT-239 Burimamide Ciproxifan Clobenpropit Conessine Impentamine Iodophenpropit Thioperamide VUF-5681 H4 JNJ 7777120 Thioperamide VUF-6002 v d e Deliriants anticholinergic hallucinogens Tropanes Atropine, Hyoscyamine, Scopolamine Benzilates Benactyzine, Ditran, EA-3167, N-Ethyl-3-piperidyl benzilate, N-Methyl-3-piperidyl benzilate, 3-Quinuclidinyl benzilate Antihistamines Benzhydryl compounds Cyclizine, Dimenhydrinate, Diphenhydramine, Doxylamine, Promethazine Others Benzydamine, Dicyclomine, Biperiden, Trihexyphenidyl Retrieved from http://en..org/wiki/Cyclizine Categories: Antihistamines | Antiemetics | Piperazines Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Dansk Suomi ไทย This page was last modified on 5 August 2008, at 04:24
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