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News About Cyproheptadine

20-September-2008 09:55:57 - Cyproheptadine Cyproheptadine Systematic IUPAC name 4-5 H-dibenzo a,dcyclohepten-5-ylidene- 1 -methylpiperidine hydrochloride Identifiers CAS number 129-03-3 ATC code R06AX02 PubChem 2913 DrugBank APRD00033 Chemical data Formula C21H21N Mol. mass 287.398 g/mol Pharmacokinetic data Bioavailability ? Protein binding 96 to 99% Metabolism Hepatic and renal Half life 1 to 4 hours Excretion Fecal and renal Therapeutic considerations Pregnancy cat. BUS Legal status PUK Routes Oral only Cyproheptadine usually as cyproheptadine hydrochloride, trade name Periactin is an antihistaminic and antiserotonergic agent. It acts as a 5-HT2 receptor antagonist and also blocks calcium channels.citation needed Uses Cyproheptadine is used in the treatment of allergies specifically hay fever and is also used to stimulate appetite in underweight people e.g. anorexia nervosa. Cyproheptadine is used in serotonin syndrome, a complex of symptoms associated with selective serotonin reuptake inhibitors, especially when taken in excess dose and in the disease carcinoid in which serotonin is overproduced by tumor cells.citation needed Recently, cyproheptadine has also been prescribed to children and adolescents with frequent migraine.citation needed Side effects While not specifically used as a sedative, cyproheptadine causes sedation, likely due to its anti-histamine effects.citation needed Digestive system: epigastric distress dysphagia, loss of appetite, nausea, vomiting, it is noted that these side effects are much more common in people with neuromuscular disorderscitation needed Cyproheptadine can also cause over-sleeping 10 Hours in children and adolescents.citation needed References December 2007 v d e Serotonin antagonists 5-HT2 Melperone - Paliperidone - Risperidone - Sertindole - Ziprasidone 5-HT3 Alosetron - Azasetron - Bemesetron - Cilansetron - Dolasetron - Granisetron - Lerisetron - Ondansetron - Palonosetron - Ramosetron - Tropisetron - Zacopride - Zatosetron Other/ungrouped Amperozide - Blonanserin - Bufotenin - Cianopramine - Cinanserin - Clozapine - Cyanopindolol - Cyproheptadine - Deramciclane - Dotarizine - Fananserin - Fenclonine - Ketanserin - Lysergic acid diethylamide - Metergoline - Methiothepin - Methysergide - Mianserin - N,N-Dimethyltryptamine - Nafronyl - Olanzapine - Pindolol - Pipamperone - Pizotyline - Quetiapine - Renzapride - Ritanserin - Sarpogrelate - Setoperone - Tolfenamic acid - Wortmannin - Xylamidine v d e Histamine antagonists H1 or non-selective Alkylamines Bepotastine Bamipine Brompheniramine Chlorpheniramine Dexbrompheniramine Dexchlorpheniramine Dimethindene Metron S Pheniramine Pyrrobutamine Talastine Thenaldine Tolpropamine Triprolidine Ethanolamines Aminoalkyl ethers Bietanautine Bromazine/Bromodiphenhydramine Carbinoxamine Chlorphenoxamine Clemastine Diphenylpyraline Diphenhydramine Doxylamine Embramine p-Methyldiphenhydramine Moxastine Orphenadrine Phenyltoloxamine Setastine Ethylenediamines Chloropyramine Chlorothen Histapyrrodine Methafurylene Mepyramine Methapyrilene Pyrilamine Talastine Thenyldiamine Thonzylamine Tripelennamine Pyribenzamine Phenothiazine Tricyclics Ahistan Etymemazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Thiazinamium Other Tricyclics Azatadine Clobenzepam Cyproheptadine Deptropine Isothipendyl Loratidine Piperazine Buclizine Chlorcyclizine Cinnarizine Clocinizine Hydroxyzine Niaprazine Oxatomide Benzhydryl compounds Cyclizine, Meclizine Others including selective, 2nd gen, 3rd gen Antazoline Astemizole Azatadine Azelastine Bepottastine Bamipine Cetoxine Clemizole Clobenztropine Deptropine Desloratadine Dimebon Ebastine Emedastine Epinastine Ketotifen Levocabastine Loratadine Mebhydrolin Mizolastine Phenindamine Pimethixene Pyrrobutamine Rupatadine Thenalidine Tritoqualine Alkylamine Acrivastine Tricyclic Olopatadine Piperazine Levocetirizine, Cetirizine Benzhydryl compounds Fexofenadine, Terfenadine H2 Cimetidine Famotidine Ranitidine Roxatidine Lafutidine Niperotidine Nizatidine H3 A-349,821 ABT-239 Burimamide Ciproxifan Clobenpropit Conessine Impentamine Iodophenpropit Thioperamide VUF-5681 H4 JNJ 7777120 Thioperamide VUF-6002 Retrieved from http://en..org/wiki/Cyproheptadine Categories: Antihistamines | Serotonin antagonistsHidden categories: All articles with statements | Articles with statements | Articles with statements since February 2008 | Articles needing additional references from December 2007 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages 日本語 This page was last modified on 21 August 2008, at 05:45

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