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20-September-2008 09:55:55 - DMCM DMCM IUPAC name methyl 4-ethyl-6,7-dimethoxy-9H-pyrido5,4-bindole-3-carboxylate Other names DMCM Identifiers CAS number 82499-00-1 PubChem 104999 SMILES CCC1=C2C3=CC=CC=C3NC2=CN=C1C=OOCOCOC Properties Molecular formula C17H18N2O4 Molar mass 314.336 g/mol Except where noted otherwise, data are given for materials in their standard state at 25 °C, 100 kPa Infobox references DMCM methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate is a drug from the beta-carboline family. It acts as an inverse agonist of benzodiazepine receptors, meaning that it causes the opposite effects to the Benzodiazepine class of drugs. As such, DMCM has anxiogenic and convulsant properties,1 and is used in scientific research to induce anxiety so that new anxiolytic medications can be tested,2 and to produce convulsions so that anticonvulsant medications can be tested.345 It has also been shown to produce analgesic effects in animals, thought to be because it produces panic which reduces the perception of pain.6 References ^ Contó MB, de Carvalho JG, Beno MA. Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacology, Biochemistry and Behaviour. 2005 Nov;823:417-26. PMID 16297441 ^ Cole BJ, Hillmann M, Seidelmann D, Klewer M, Jones GH. Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat. Psychopharmacology Berlin. 1995 Sep;1211:118-26. PMID 8539336 ^ Brodie MJ. Tiagabine pharmacology in profile. Epilepsia. 1995;36 Suppl 6:S7-S9. PMID 8595791 ^ De Sarro G, Chimirri A, McKernan R, Quirk K, Giusti P, De Sarro A. Anticonvulsant activity of azirino1,2-d1,4benzodiazepines and related 1,4-benzodiazepines in mice. Pharmacology, Biochemistry and Behaviour. 1997 Sep;581:281-9. PMID 9264104 ^ Leppä E, Vekovischeva OY, Lindén AM, Wulff P, Oberto A, Wisden W, Korpi ER. Agonistic effects of the beta-carboline DMCM revealed in GABAA receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;484:469-78. PMID 15755475 ^ Sieve AN, King TE, Ferguson AR, Grau JW, Meagher MW. Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacology Berlin. 2001 Jan 1;1532:180-90. PMID 11205417 Tablets This pharmacology-related article is a stub. Retrieved from http://en..org/wiki/DMCM Categories: Pharmacology stubs | Drugs | GABA antagonists | Convulsants Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 June 2008, at 05:46
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