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20-September-2008 09:55:51 - DPT vaccine DPT, sometimes DTP is a mixture of three vaccines, to immunize against diphtheria, pertussis whooping cough and tetanus. DTP vaccine may be distinguished as DTwP and DTaP or TDaP, with wP referring to whole cell pertussis and aP referring to acellular pertussis. The acellular form is considered safer and contains far fewer antigens than the older preparation. Current versions of DTP in Europe do not contain preservatives; older ones contained Thiomersal. In the Netherlands, the acronym DTP is used as well, but differently. In that country, DTP refers to a mixture of diphtheria, tetanus and poliomyelitis vaccines, whereas DKTP refers to a mixture of diphtheria, pertussis kinkhoest, tetanus and poliomyelitis vaccines. Contents 1 Diptheria Tetanus whole cell Pertussis vaccine 2 DTaP 3 Tdap 4 References Diptheria Tetanus whole cell Pertussis vaccine Severe problems closely following DPT immunization happen very rarely. These include a serious allergic reaction, prolonged seizures, a decrease in consciousness, lasting brain disease, or even death. British research in the 1980s into whole-cell DTP,1 which is now rarely available in developed countries, suggested that such severe neurologic events occur after approximately 1 in 140,000 doses of the DPT vaccine 0.0007%. Most of the reactions to whole-cell DPT injection are thought to be from the pertussis component. In 1994, the Institute of Medicine of the US National Academy of Sciences published a report stating that if the first symptoms of neurological damage occurred within the first seven days following vaccination with whole-cell pertussis vaccine, the evidence was compatible with the possibility that it could be the cause of permanent brain damage in otherwise apparently healthy children. It continued by stating: This serious acute neurologic response to whole-cell DPT is a rare event. The estimated excess risk ranged from 0 to 10.5 per million immunizations IOM, 1991. The committee stresses that this is not the strongest statement regarding causality; the evidence does not establish or prove a causal relation.... The evidence remains insufficient to indicate the presence or absence of a causal relation between DPT and chronic nervous system dysfunction under any other circumstances. That is, because the NCES is the only systematic study of chronic nervous system dysfunctions after DPT, the committee can only comment on the causal relation between DPT and those chronic nervous system dysfunctions under the conditions studied by the NCES. In particular, it should be noted that the chronic dysfunctions associated with DPT followed a serious acute neurologic illness that occurred in children within 7 days after receiving DPT.1 Moderate reactions to DPT vaccines occur in 0.1% to 1.0% of children and include ongoing crying for three hours or more, a high fever up to 40 °C / 105 °F, and an unusual, high-pitched crying. A safer acellular pertussis vaccine DTaP was introduced in the US in 1991; since 2002, whole-cell pertussis vaccines are no longer used in the US. The usual course of immunisation is five doses between 2 months and 15 years. Also known by the trademarked name Triple Antigen2. DTaP DTaP is an acronym for the combined diphtheria, tetanus, and acellular pertussis vaccine. The a denotes the vaccine's acellular pertussis components, distinguishing it from whole-cell, inactivated DTP aka DTwP vaccine. The acellular vaccine uses antigenic fragments of the pertussis pathogen to induce immunity. The advantage of the acellular vaccine is that it causes substantially fewer side-effects estimated at 90% fewer, which commonly include local pain and redness, and/or fever. Both DTP and DTaP appear to be equally efficacious in generating immunity, but DTaP is universally accepted as safer. Most of the developed world has switched to DTaP, but developing countries continue to use DTP, which is substantially cheaper. Tdap Tdap is the acronym for the collective vaccines preventing tetanus, diphtheria, and pertussis in adolescents and adults that were licensed in the United States in spring of 2005. These vaccines differ from the childhood DTaP vaccines in their indication. As indicated by the lower case d and p, the concentration of diphtheria and pertussis toxoids has been reduced in these formulations to prevent adverse reactions. Two Tdap vaccines are available in the U.S. AdacelR,manufactured by sanofi pasteur, is licensed for use in adults ages 11 to 64. BoostrixR, manufactured by GlaxoSmithKline, is licensed for use in adolescents ages 10 to 19. The U.S.'s Advisory Committee on Immunization Practices ACIP and Canada's National Advisory Committee on Immunization NACI both recommended adolescents and adults receive Tdap in place of their next Td booster recommend to be given every 10 years.2 3 4 Tdap can be used as prophylaxis for tetanus wound management. Five years between doses of Td or doses of Td and Tdap is the current standard of care; frequent exposure to tetanus toxoid can cause local reactions. People who will be in contact with young infants are encouraged to get Tdap even if it has been less than 5 years since Td or TT to reduce the risk of infants being exposed to pertussis. The ACIP statement on Tdap use in adolescents encourages 5 years between Td and Tdap to reduce this risk; however, both suggest that shorter intervals may be appropriate in some circumstances, such as for protection in pertussis outbreaks. NACI suggests intervals shorter than 5 years can be used for catch-up programs and other instances where programmatic concerns make 5-year intervals difficult. References ^ DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis 1994. Institute of Medicine ^ Preventing Tetanus, Diphtheria, and Pertussis Among Adolescents: Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccines, K. R. Broder et al., MMWR Recommendations and Reports, March 24, 2006 / 55RR03, 1-34, page 18. ^ ACIP Votes to Recommend Use of Combined Tetanus, Diphtheria and Pertussis Tdap Vaccine for Adults, http://www.cdc.gov/nip/vaccine/tdap/tdap_adult_recs.pdf ^ Interval Between Administration of Vaccines Against Diphtheria, Tetanus, and Pertussis http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/05vol31/acs-dcc-8-9/9_e.html Price's Textbook of the Practice of Medicine. ISBN 0-19-442344-1 Immunisation Against Infectious Disease. 1996. - The Green Book. with updates Department of Health United Kingdom. 3 v d e Vaccines, Vaccination, Immunization, and Inoculation see also artificial induction of immunity Development Adjuvants Cancer vaccines DNA vaccination HIV Live vector vaccine Models Timeline Trial Administration Global: GAVI Policy Schedule Vaccine injury USA: ACIP VAERS VSD Vaccine court Vaccines live Anthrax BCG tuberculosis Flu MMR MMRV PolioOPV Rotavirus Smallpox Varicella Yellow fever Inactivated/toxoid inactivated virus: Flu HAV PolioIPV inactivated bacteria/toxoid: DTwP conjugate: Hib PCV Other subunit: Anthrax DTaP HPV recombinant DNA: HBV other: Anthrax PPV Controversy General A-CHAMP MMR NCVIA Pox party Safe Minds Thiomersal See also List of vaccine topics Epidemiology Eradication of infectious diseases Retrieved from http://en..org/wiki/DPT_vaccine Categories: Vaccines Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages БългарÑ?ки Deutsch Español Nederlands 日本語 ‪Norsk nynorsk‬ Polski Suomi Türkçe This page was last modified on 4 August 2008, at 08:29
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