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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 09:55:57 - Desloratadine Desloratadine Systematic IUPAC name 8-chloro-6,11-dihydro-11-4-piperdinylidene- 5H-benzo5,6cyclohepta1,2-bpyridine Identifiers CAS number 100643-71-8 ATC code R06AX27 PubChem 124087 DrugBank APRD00324 Chemical data Formula C19H19ClN2 Mol. mass 310.82 SMILES eMolecules PubChem Pharmacokinetic data Bioavailability Rapidly absorbed Protein binding 85% Metabolism Liver Half life 27 hours Excretion 40% as conjugated metabolites into urine Similar amount into the feces Therapeutic considerations Licence data EU, US Pregnancy cat. B1AU CUS Legal status POMUK â„ž-onlyUS Routes oral Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn, Claramax, Clarinex and Aerius. It is an active metabolite of loratadine, which is also on the market. Contents 1 Available forms 2 Mechanism of action 3 Side effects 4 Desloratadine vs. loratadine 5 References Available forms Desloratadine is available as tablets including orally disintegrating and extended release and as syrup. 1 Mechanism of action Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.2 Side effects Most common side-effects are fatigue, dry mouth, headache, and gastrointestinal disturbances. Desloratadine vs. loratadine Desloratadine is the major metabolite of loratadine. There are no head-to-head randomised controlled trials of the two drugs. A survey of patients dissatisfied with loratadine published in August 2003 reported equal or better satisfaction with desloratadine3, concluding: When severity of disease was controlled for in the analysis, a pattern emerged suggesting greater levels of satisfaction amongst loratadine dissatisfied patients who converted to desloratadine. Point estimates suggest a consistent pattern favoring desloratadine patient satisfaction, with statistically significant results reported for sum of adverse effects, nighttime awakening due to symptoms, symptom severity just prior to the next dose, and overall satisfaction p 0.05. A November 2003 article published in the journal American Family Physician about the safety, tolerability, effectiveness, price, and simplicity of desloratadine concluded the following:4 Desloratadine is similar in effectiveness to fexofenadine and would be expected to produce results similar to loratadine and other nonsedating antihistamines. There is no clinical advantage to switching a patient from loratadine to desloratadine. However, it may be an option for patients whose medical insurance no longer covers loratadine if the co-pay is less than the cost of the over-the-counter product. References ^ FDA Electronic Orange Book http://www.fda.gov/cder/ob/default.htm ^ Mann R, Pearce G, Dunn N, Shakir S 2000. Sedation with non-sedating antihistamines: four prescription-event monitoring studies in general practice. BMJ 320 7243: 1184-6. doi:10.1136/bmj.320.7243.1184. PMID 10784544. ^ Glass D, Harper A Aug 13, 2003. Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine. BMC Fam Pract 4: 10. doi:10.1186/1471-2296-4-10. PMID 12917016. ^ See S 2003. Desloratadine for allergic rhinitis. Am Fam Physician 68 10: 2015-6. PMID 14655812. v d e Histamine antagonists H1 or non-selective Alkylamines Bepotastine Bamipine Brompheniramine Chlorpheniramine Dexbrompheniramine Dexchlorpheniramine Dimethindene Metron S Pheniramine Pyrrobutamine Talastine Thenaldine Tolpropamine Triprolidine Ethanolamines Aminoalkyl ethers Bietanautine Bromazine/Bromodiphenhydramine Carbinoxamine Chlorphenoxamine Clemastine Diphenylpyraline Diphenhydramine Doxylamine Embramine p-Methyldiphenhydramine Moxastine Orphenadrine Phenyltoloxamine Setastine Ethylenediamines Chloropyramine Chlorothen Histapyrrodine Methafurylene Mepyramine Methapyrilene Pyrilamine Talastine Thenyldiamine Thonzylamine Tripelennamine Pyribenzamine Phenothiazine Tricyclics Ahistan Etymemazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Thiazinamium Other Tricyclics Azatadine Clobenzepam Cyproheptadine Deptropine Isothipendyl Loratidine Piperazine Buclizine Chlorcyclizine Cinnarizine Clocinizine Hydroxyzine Niaprazine Oxatomide Benzhydryl compounds Cyclizine, Meclizine Others including selective, 2nd gen, 3rd gen Antazoline Astemizole Azatadine Azelastine Bepottastine Bamipine Cetoxine Clemizole Clobenztropine Deptropine Desloratadine Dimebon Ebastine Emedastine Epinastine Ketotifen Levocabastine Loratadine Mebhydrolin Mizolastine Phenindamine Pimethixene Pyrrobutamine Rupatadine Thenalidine Tritoqualine Alkylamine Acrivastine Tricyclic Olopatadine Piperazine Levocetirizine, Cetirizine Benzhydryl compounds Fexofenadine, Terfenadine H2 Cimetidine Famotidine Ranitidine Roxatidine Lafutidine Niperotidine Nizatidine H3 A-349,821 ABT-239 Burimamide Ciproxifan Clobenpropit Conessine Impentamine Iodophenpropit Thioperamide VUF-5681 H4 JNJ 7777120 Thioperamide VUF-6002 Retrieved from http://en..org/wiki/Desloratadine Categories: H1 receptor antagonists Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Español Français Nederlands Polski РуÑ?Ñ?кий ไทย This page was last modified on 12 August 2008, at 15:28
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