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20-September-2008 09:55:57 - Dimethylethanolamine Dimethylethanolamine IUPAC name 2-dimethylaminoethanol Other names dimethylamino ethanol Deanol Abbreviations DMAE Molecular formula C4H11NO Molar mass 89.14 CAS number 108-01-0 Density 0.89 g/mL Melting point -70 Boiling point 133-134 SMILES CNCCCO Except where noted otherwise, data are given for materials in their standard state at 25 °C, 100 kPa Infobox references Dimethylaminoethanol, also known as DMAE or dimethylethanolamine, is an organic compound. This compound also goes by the names of N,N-dimethyl-2-aminoethanol, beta-dimethylaminoethyl alcohol, beta-hydroxyethyldimethylamine and Deanol. It is a liquid with a color that ranges from clear to pale yellow. Contents 1 Industrial uses 2 Biochemical precursor 2.1 Research 3 See also 4 References 4.1 Studies Industrial uses Dimethylaminoethanol is used as a curing agent for polyurethanes and epoxy resins. It is also used in mass quantities for water treatment, and to some extent into the coatings industry. It is used to the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals, emulsifiers, and corrosion inhibitors. Also it is an additive to paint removers, boiler water, and amino resins. Biochemical precursor Dimethylaminoethanol is related to choline and is a biochemical precursor to the neurotransmitter acetylcholine, and found naturally in fishes like sardines and anchovies. It is reported to have nootropic effects, although research on this chemical has found both positive and negative potential results. It is believed that dimethylaminoethanol is methylated to produce choline in the brain1. It is known that dimethylaminoethanol is processed by the liver into choline; however, the choline molecule is charged and cannot pass the blood-brain barrier. Research Short term studies have shown an increase in vigilance and alertness, with a positive influence on mood.2 Long term studies are equivocal. Some showed dimethylaminoethanol to increase the lifespan of animals in which it was tested, while others indicate a possible reduction in the average life span of quail.3 With the uncertainty of whether this could be extrapolated to humans, dimethylaminoethanol supplementation is not generally recommended. It is possible that dose is a major determining factor in the overall effects of dimethylaminoethanol - a high dose could produce effects opposite to those sought and contribute to life-shortening.4 See also Ethanolamine Methylethanolamine References ^ N. R. Zahniser, D. Chou, I. Hanin. Is 2-dimethylaminoethanol deanol indeed a precursor of brain acetylcholine? A gas chromatographic evaluation, Journal of Pharmacology and Experimental Therapeutics 2003:545-559, 1977. ^ W. Dimpfel, W. Wedekind, I. Keplinger, Efficacy of dimethylaminoethanol DMAE containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states, European Journal Medical Research 85:183-191, 2003. ^ A. Cherkin, M.J. Exkardt, Effects of dimethylaminoethanol upon life-span and behavior of aged Japanese quail, Journal of Gerontology 321:38-45, 1977. ^ G. Morissette, L. Germain, F. Marceau, The antiwrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology, British Journal of Dermatology 1563 pp.433-439, 2007. Studies Earliest research Pfeiffer C, et al. Stimulant effect of 2-dimethylaminoethanol; possible precursor of brain acetylcholine. Science 1263274:610-611, 1957. 1 As a treatment for tardive dyskinesia Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol deanol? European Neurology 316:423-425, 1991. 2 As an unsuccessful treatment for Alzheimer's disease Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. American Journal of Psychiatry 1387:970-972, 1981. 3 As a treatment for attention-deficit hyperactivity disorder DMAE and Bacopa for Attention Deficit Disorder v d e Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics N06B Centrally acting sympathomimetics Amphetamine - Amphetaminil - Atomoxetine - Dextroamphetamine - Dextromethamphetamine - Fencamfamin - Fenozolone - Fenetylline - Methylphenidate - Mesocarb - Pemoline - Pipradrol - Prolintane Xanthine derivatives Caffeine - Propentofylline Glutamate receptor Racetams Aniracetam - Nefiracetam - Oxiracetam - Phenylpiracetam - Piracetam - Pramiracetam Ampakines CX-516 - CX-546 - CX-614 - CX-691 - CX-717 - IDRA-21 - LY-503,430 - PEPA Eugeroics / Benzhydryl compounds Adrafinil - Armodafinil - Modafinil Histamine H3 receptor antagonists ABT-239 - Ciproxifan Other psychostimulants and nootropics Acetylcarnitine - Citicoline - Cyprodenate - Idebenone - Ispronicline - Deanol - Dimebon - Fipexide - Linopirdine - Meclofenoxate - Nizofenone - Pirisudanol - Pyritinol - Sulbutiamine - Taltirelin - Tricyanoaminopropene - Vinpocetine Retrieved from http://en..org/wiki/Dimethylethanolamine Categories: Amines | Alcohols | Nootropics Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Français 日本語 Polski This page was last modified on 21 June 2008, at 01:33
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