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20-September-2008 09:55:53 - ART4 Redirected from Dombrock antigen system ADP-ribosyltransferase 4 Dombrock blood group Identifiers Symbols ART4; CD297; DO; DOK1 External IDs OMIM: 110600 MGI: 1202710 HomoloGene: 10883 Gene ontology Molecular function: NADP+-protein-arginine ADP-ribosyltransferase activity transferase activity, transferring glycosyl groups GPI anchor binding Cellular component: membrane Biological process: protein amino acid ADP-ribosylation arginine metabolic process RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 420 109978 Ensembl ENSG00000111339 ENSMUSG00000030217 Uniprot Q93070 n/a Refseq NM_021071 mRNA NP_066549 protein NM_026639 mRNA NP_080915 protein Location Chr 12: 14.87 - 14.89 Mb Chr 6: 136.81 - 136.82 Mb Pubmed search 1 2 ADP-ribosyltransferase 4 Dombrock blood group, also known as ART4, is a human gene.1 ART4 has also been designated as CD297 cluster of differentiation 297. This gene encodes a protein that contains a mono-ADP-ribosylation ART motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.1 References ^ a b Entrez Gene: ART4 ADP-ribosyltransferase 4 Dombrock blood group. Further reading Reid ME 2003. The Dombrock blood group system: a review.. Transfusion 43 1: 107-14. PMID 12519438. Tippett P 1967. Genetics of the Dombrock blood group system.. J. Med. Genet. 4 1: 7-11. PMID 6034522. Eiberg H, Mohr J 1996. Dombrock blood group DO: assignment to chromosome 12p.. Hum. Genet. 98 5: 518-21. PMID 8882867. Koch-Nolte F, Haag F, Braren R, et al. 1997. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins.. Genomics 39 3: 370-6. doi:10.1006/geno.1996.4520. PMID 9119374. Mauthe J, Coghlan G, Zelinski T 2000. Confirmation of the assignment of the Dombrock blood group locus DO to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2.. Vox Sang. 79 1: 53-6. PMID 10971215. Gubin AN, Njoroge JM, Wojda U, et al. 2000. Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family.. Blood 96 7: 2621-7. PMID 11001920. Wu GG, Jin SZ, Deng ZH, Zhao TM 2002. Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors.. Vox Sang. 81 1: 49-51. PMID 11520417. Rios M, Hue-Roye K, Øyen R, et al. 2002. Insights into the Holley- and Joseph- phenotypes.. Transfusion 42 1: 52-8. PMID 11896313. Rios M, Storry JR, Hue-Roye K, et al. 2002. Two new molecular bases for the Dombrock null phenotype.. Br. J. Haematol. 117 3: 765-7. PMID 12028057. Glowacki G, Braren R, Firner K, et al. 2003. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse.. Protein Sci. 11 7: 1657-70. PMID 12070318. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Grahnert A, Friedrich M, Engeland K, Hauschildt S 2005. Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements.. Biochim. Biophys. Acta 1730 3: 173-86. doi:10.1016/j.bbaexp.2005.08.001. PMID 16140404. External links MeSH ART4+protein,+human This membrane protein-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Proteins: clusters of differentiation see also list of human clusters of differentiation 1-50 CD1 a-c, 1A, 1D, 1E - CD2 - CD3 γ, δ, ε - CD4 - CD5 - CD6 - CD7 - CD8 a - CD9 - CD10 - CD11 a, b, c - CD13 - CD14 - CD15 - CD16 A, B - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 A, B - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 a, b, c, d - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 a, b, c, d, e, f - CD50 51-100 CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 E, L, P - CD63 - CD64 - CD66 a, b, c, d, e, f - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 a, b - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 a, d, e, h, j, k - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100 101-150 CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 a, b - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 a, b - CD121 a, b - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150 151-200 CD151 - CD152 - CD153 - CD154 - CD155 - CD156 a, b, c - CD157 - CD158 a, d, e, i, k - CD159 a, c - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 a, b - CD168 - CD169 - CD170 - CD171 - CD172 a, b, g - CD174 - CD177 - CD178 - CD179 a, b - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200 201-250 CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 a, b - CD212 - CD213a 1, 2 - CD217 - CD218 a, b - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 a, b - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249 251-300 CD252 - CD253 - CD254 - CD256 - CD257 - CD258 - CD261 - CD262 - CD264 - CD265 - CD266 - CD267 - CD268 - CD269 - CD271 - CD272 - CD273 - CD274 - CD275 - CD276 - CD278 - CD279 - CD280 - CD281 - CD282 - CD283 - CD284 - CD286 - CD288 - CD289 - CD290 - CD292 - CDw293 - CD294 - CD295 - CD297 - CD298 - CD299 301-350 CD300A - CD304 - CD305 - CD307 - CD309 - CD312 - CD314 - CD315 - CD316 - CD317 - CD318 - CD320 - CD321 - CD322 - CD324 - CD325 - CD326 - CD328 - CD329 - CD331 - CD332 - CD333 - CD334 - CD335 - CD336 - CD337 - CD338 - CD339 - CD340 - CD344 - CD349 - CD350 Retrieved from http://en..org/wiki/ART4 Categories: Genes on chromosome 12 | Human proteins | Membrane protein stubs | Clusters of differentiationHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 10 July 2008, at 04:39
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