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20-September-2008 09:55:48 - Dorzolamide 200px 200px Dorzolamide Systematic IUPAC name 2-ethylamino-4-methyl-5, 5-dioxo-5$l^6, 7-dithiabicyclo4.3.0 nona-8,10- diene-8-sulfonamide Identifiers CAS number 130693-82-2 120279-96-1 ATC code S01EC03 PubChem 3154 DrugBank APRD00577 Chemical data Formula C10H16N2O4S3 Mol. mass 324.443 g/mol SMILES eMolecules PubChem Pharmacokinetic data Bioavailability ? Protein binding ~33% Metabolism ? Half life 4 months Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes ? Dorzolamide is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. This drug was the first drug in human therapy market introduction 1995 which resulted from structure-based drug design. Trusopt dorzolamide hydrochloride ophthalmic solution is a carbonic anhydrase inhibitor formulated for topical ophthalmic use. Trusopt is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension. This drug was developed by University of Florida researchers.1 The primary creator most cred with pioneering this drug was Dr. Thomas H. Maren.2 References ^ University of Florida facts ^ University of Florida News - Dr. Thomas Maren, A Founding Father Of UF's Medical College And Renowned Basic Scientist, Dies At Summer Home In Maine Further reading Kubinyi H 1999. Chance favors the prepared mind--from serendipity to rational drug design. J Recept Signal Transduct Res 19 1-4: 15-39. PMID 10071748. Plummer C, MacKay E, Gelatt K. Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs.. Vet Ophthalmol 9 4: 245-9. doi:10.1111/j.1463-5224.2006.00469.x. PMID 16771760. Grover S, Apushkin M, Fishman G 2006. Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.. Am J Ophthalmol 141 5: 850-8. doi:10.1016/j.ajo.2005.12.030. PMID 16546110. Almeida G, Faria e Souza S 2006. Effect of topical dorzolamide on rabbit central corneal thickness.. Braz J Med Biol Res 39 2: 277-81. doi:10.1590/S0100-879X2006000200015. PMID 16470316. v d e University of Florida Academics College of Medicine · Levin College of Law · College of Engineering · Warrington College of Business Administration · Fisher School of Accounting · College of Pharmacy · College of Dentistry · College of Veterinary Medicine · College of Journalism and Communications · College of Public Health and Health Professions · Rinker School of Building Construction · College of Nursing · College of Liberal Arts and Sciences · College of Health and Human Performance · College of Agricultural and Life Sciences · College of Education · College of Design Construction and Planning · College of Fine Arts · Bob Graham Center for Public Service · Continuing Education Athletics Southeastern Conference · Florida Gators · University Athletic Association · Gator Football · Gator Basketball · Ben Hill Griffin Stadium · Stephen C. O'Connell Center · Softball Stadium · Alfred A. McKethan Stadium · University Golf Course · Florida-Florida State rivalry · Florida-Georgia rivalry · Florida-Tennessee rivalry · Orange and Blue Research Association of American Universities · J. Hillis Miller Health Science Center · George A. Smathers Libraries · McKnight Brain Institute · Shands at the University of Florida · Shands Jacksonville · UF Training Reactor · MacroCenter · Mag Lab · Burnham Institute · Moffitt Cancer Center Research Institute · Gran Telescopio Canarias · Institute of Food and Agricultural Sciences · P.K. Yonge Research School · Gatorade · Trusopt · Sid Martin Biotechnology Incubator People List of notable Alumni · List of University of Florida Presidents · List of notable Faculty and Administrators · List of Honorary Degree recipients · List of Football players · List of Basketball players · List of Baseball players · List of Golfers · List of Olympians · Alumni Association Culture Century Tower · Gator Growl · Albert and Alberta · The Independent Florida Alligator · We are the Boys · List of UF fraternities and sororities · Theatre Strike Force · Phi Beta Kappa · Florida Blue Key · Plaza of the Americas · Miss University of Florida · Gator Chomp · ACCENT Speaker's Bureau · Marching Band · Mr. Two Bits Broadcasting WUFT TV · WUFT-FM / WJUF · WLUF-LP · WRUF AM · WRUF-FM · Old WRUF Radio Station Campus Southwest Recreation Center · Student housing · J. Wayne Reitz Union · University Auditorium · Phillips Center for the Performing Arts · Samuel P. Harn Museum of Art · Museum of Natural History · Baughman Center · University of Florida Campus Historic District · Florida Gymnasium · Lake Alice · Murphree Area · The Hub Tablets This pharmacology-related article is a stub. v d e Ophthalmologicals: antiglaucoma preparations and miotics S01E Sympathomimetics Apraclonidine Brimonidine Clonidine Dipivefrine Epinephrine Parasympathomimetics M: Aceclidine Pilocarpine M/N: Acetylcholine Carbachol AI: Demecarium Echothiophate Stigmine Fluostigmine, Neostigmine, Physostigmine Paraoxon Carbonic anhydrase inhibitors Acetazolamide Brinzolamide Diclofenamide Dorzolamide Methazolamide Beta blocking agents Befunolol Betaxolol Carteolol Levobunolol Metipranolol Timolol Prostaglandin analogues Bimatoprost Latanoprost Travoprost Unoprostone Other agents Dapiprazole Guanethidine Retrieved from http://en..org/wiki/Dorzolamide Categories: University of Florida | Pharmacology stubs | Carbonic anhydrase inhibitors | Thiophenes Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch 日本語 This page was last modified on 12 August 2008, at 06:25
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