Sierra Acai Company
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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 09:55:48 - Epoprostenol Epoprostenol Systematic IUPAC name 5Z-5-3aR,4R,5R,6aS-5-hydroxy-4- E,3S-3-hydroxyoct-1-enyl-3,3a,4,5,6,6a- hexahydrocyclopentadfuran-2-ylidenepentanoic acid Identifiers CAS number 35121-78-9 ATC code B01AC09 PubChem 114805 DrugBank APRD00949 Chemical data Formula C20H32O5 Mol. mass 352.465 g/mol SMILES eMolecules PubChem Pharmacokinetic data Bioavailability Not applicable IV only Metabolism To 6-keto-PGF1α and 6,15-diketo-13,14-dihydro-PGF1α Half life 6 minutes in vitro Excretion Renal Therapeutic considerations Licence data US Pregnancy cat. BUS Legal status ℞ Prescription only Routes Intravenous Epoprostenol is a synthetic form of prostacyclin, and is used to treat pulmonary hypertension. It is sold under the trade name Flolan. Contents 1 Clinical pharmacology 2 Administration 3 History 4 Marketing Clinical pharmacology As an analogue of prostacyclin PGI2, epoprostenol effects vasodilation, which in turn lowers the blood pressure. Epoprotstenol also inhibits platelet aggregation, though the role this phenomenon may play in relation to pulmonary hypertension has yet to be determined. Administration Epoprostenol is given via continuous infusion that requires a semi-permanent central venous catheter. This means that the patient must be attached to an infusion pump at all times. This delivery system can cause sepsis and thrombosis. Because epoprostenol is unstable, it must be kept cold, even during administration. Since it has a half-life of 3 to 5 minutes, the infusion has to be continuous 24/7, and an interruption can lead to a potentially fatal rebound of symptoms. History Epoprostenol was developed by GlaxoSmithKline and approved in the USA as a medicine in 1995. Marketing It was licensed to Myogen, which was subsequently acquired by Gilead Sciences. Flolan is marketed in the United States by Gilead Sciences and elsewhere by GlaxoSmithKline. v d e Antithrombotics thrombolytics, anticoagulants and antiplatelet drugs B01 Antiplatelet drugs Glycoprotein IIb/IIIa inhibitors Abciximab Eptifibatide Tirofiban ADP receptor/P2Y12 inhibitors Clopidogrel Ticlopidine Prasugrel Prostaglandin analogue PGI2 Beraprost Prostacyclin Iloprost Treprostinil COX inhibitors Acetylsalicylic acid/Aspirin Aloxiprin Carbasalate calcium Other Ditazole Cloricromen Dipyridamole Indobufen Picotamide Triflusal Anticoagulants Vitamin K antagonists inhibit II, VII, IX, X Acenocoumarol Clorindione Coumatetralyl Dicoumarol Dicumarol Diphenadione Ethyl biscoumacetate Phenprocoumon Phenindione Tioclomarol Warfarin Heparin group Antithrombin III Danaparoid Sulodexide low molecular weight heparin Bemiparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin Direct thrombin II inhibitors Argatroban Bivalirudin Dabigatran Desirudin Hirudin Lepirudin Melagatran Ximelagatran Factor Xa inhibitors Apixaban Otamixaban Rivaroxaban oligosaccharides Fondaparinux, Idraparinux Other Defibrotide Dermatan sulfate Ramatroban Thrombolytic drugs/ fibrinolytics plasminogen activators: TPA Alteplase, Reteplase, Tenecteplase UPA Urokinase, Saruplase Streptokinase Anistreplase Monteplase other serine endopeptidases: Ancrod Drotrecogin alfa/Protein C Fibrinolysin Brinase Non-medicinal Citrate EDTA Oxalate v d e Medications used in the management of pulmonary arterial hypertension B01, C02 Prostacyclin analogues Beraprost, Epoprostenol, Iloprost, Treprostinil Endothelin receptor antagonists Ambrisentan, Bosentan, Sitaxsentan PDE5 inhibitors Sildenafil, Tadalafil Adjunctive therapy Calcium channel blockers, Diuretics, Digoxin, Oxygen therapy, Warfarin v d e Eicosanoids: prostaglandins Endogenous/series 2 D2 - E2 Dinoprostone - F2 Dinoprost - H2 - I2 Prostacyclin Prostaglandin analogues E: Alprostadil - Enprostil - Misoprostol F: Bimatoprost - Carboprost - Latanoprost - Travoprost I: Beraprost - Epoprostenol - Iloprost - Treprostinil Retrieved from http://en..org/wiki/Epoprostenol Categories: Orphan drugs | Prostaglandins Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 15 November 2007, at 21:19
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