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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 09:55:57 - Famotidine Famotidine Systematic IUPAC name 2-4-2-amino-sulfamoylimino-methyl ethylsulfanylmethyl-1,3-thiazol-2-ylguanidine Identifiers CAS number 76824-35-6 ATC code A02BA03 PubChem 3325 DrugBank APRD00296 Chemical data Formula C8H15N7O2S3 Mol. mass 337.449 g/mol Pharmacokinetic data Bioavailability 20-66% Protein binding 10-28% Metabolism hepatic-less than 30% Half life 2.5-4 hours clinical half-life 8-12 hours Excretion Principally excreted unchanged in urine Therapeutic considerations Licence data US Pregnancy cat. B1 Au, B U.S. Legal status S3/S4 Au, POM/OTC UK, OTC/â„ž-only U.S. Routes Oral, IV Famotidine INN pronounced /fəˈmÉ’tɪdiË?n/ is a histamine H2-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease PUD and gastroesophageal reflux disease GERD/GORD. It is commonly marketed by JJ/Merck under the trade names Pepcidine and Pepcid. Unlike cimetidine, the first H2 antagonist, famotidine has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other drugs.1 Contents 1 History and development 2 Clinical use 3 Adverse effects 4 References History and development Famotidine was developed by Merck Co. and is marketed by a joint venture between Merck and Johnson Johnson. The imidazole-ring of cimetidine was replaced with a 2-guanidinothiazole ring. Famotidine proved to be 30 times more active than cimetidine. It was first marketed in 1985. Pepcid RPD orally-disintegrating tablets that are not swallowed was released in 1999. Generic preparations became available in 2001, e.g. Fluxid Schwarz or Quamatel Gedeon Richter Ltd.. In the United States, a product called Pepcid Complete is available that combines famotidine with an antacid in a chewable tablet to ameliorate the relatively slow onset of effects. In the UK, this product is known as Pepcidtwo. Clinical use Main article: H2 antagonist Certain preparations of famotidine are available over the counter OTC in various countries. In the United States, preparations of 10 mg and 20 mg tablets, sometimes in combination with a more traditional antacid, are available OTC. Larger doses still require a prescription. Famotidine is given to surgery patients before operations to prevent post-operation nausea and to reduce the risk of aspiration pneumonitis. Adverse effects Few adverse drug reactions are associated with famotidine use. In clinical trials, the most common adverse effects were headache, dizziness, and constipation or diarrhea.2 References ^ Humphries TJ, Merritt GJ August 1999. Review article: drug interactions with agents used to treat acid-related diseases. Aliment. Pharmacol. Ther. 13 Suppl 3: 18-26. doi:10.1046/j.1365-2036.1999.00021.x. PMID 10491725. ^ Pepcid Side Effects Drug Interactions. RxList.com 2008. Retrieved on 2008-07-31. v d e Histamine antagonists H1 or non-selective Alkylamines Bepotastine Bamipine Brompheniramine Chlorpheniramine Dexbrompheniramine Dexchlorpheniramine Dimethindene Metron S Pheniramine Pyrrobutamine Talastine Thenaldine Tolpropamine Triprolidine Ethanolamines Aminoalkyl ethers Bietanautine Bromazine/Bromodiphenhydramine Carbinoxamine Chlorphenoxamine Clemastine Diphenylpyraline Diphenhydramine Doxylamine Embramine p-Methyldiphenhydramine Moxastine Orphenadrine Phenyltoloxamine Setastine Ethylenediamines Chloropyramine Chlorothen Histapyrrodine Methafurylene Mepyramine Methapyrilene Pyrilamine Talastine Thenyldiamine Thonzylamine Tripelennamine Pyribenzamine Phenothiazine Tricyclics Ahistan Etymemazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Thiazinamium Other Tricyclics Azatadine Clobenzepam Cyproheptadine Deptropine Isothipendyl Loratidine Piperazine Buclizine Chlorcyclizine Cinnarizine Clocinizine Hydroxyzine Niaprazine Oxatomide Benzhydryl compounds Cyclizine, Meclizine Others including selective, 2nd gen, 3rd gen Antazoline Astemizole Azatadine Azelastine Bepottastine Bamipine Cetoxine Clemizole Clobenztropine Deptropine Desloratadine Dimebon Ebastine Emedastine Epinastine Ketotifen Levocabastine Loratadine Mebhydrolin Mizolastine Phenindamine Pimethixene Pyrrobutamine Rupatadine Thenalidine Tritoqualine Alkylamine Acrivastine Tricyclic Olopatadine Piperazine Levocetirizine, Cetirizine Benzhydryl compounds Fexofenadine, Terfenadine H2 Cimetidine Famotidine Ranitidine Roxatidine Lafutidine Niperotidine Nizatidine H3 A-349,821 ABT-239 Burimamide Ciproxifan Clobenpropit Conessine Impentamine Iodophenpropit Thioperamide VUF-5681 H4 JNJ 7777120 Thioperamide VUF-6002 v d e Drugs for acid related disorders: Drugs for peptic ulcer and GERD/GORD A02B H2 antagonists Cimetidine, Famotidine, Lafutidine, Niperotidine, Nizatidine, Ranitidine, Roxatidine Prostaglandins/analogues Misoprostol, Enprostil Proton pump inhibitors Esomeprazole, Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole, Tenatoprazole Other Carbenoxolone, Cetraxate, Sucralfate, Pirenzepine, Troxipide Retrieved from http://en..org/wiki/Famotidine Categories: Guanidines | H2 receptor antagonists | Thiazoles Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Español Italiano Nederlands 日本語 Polski ไทย Türkçe This page was last modified on 16 August 2008, at 23:15
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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