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20-September-2008 09:55:58 - Glycerol-3-phosphate dehydrogenase glycerol-3-phosphate dehydrogenase 1 soluble Identifiers Symbol GPD1 Entrez 2819 HUGO 4455 OMIM 138420 RefSeq NM_005276 UniProt P21695 Other data EC number 1.1.1.8 Locus Chr. 12 q12-q13 glycerol-3-phosphate dehydrogenase 2 mitochondrial Identifiers Symbol GPD2 Entrez 2820 HUGO 4456 OMIM 138430 RefSeq NM_000408 UniProt P43304 Other data EC number 1.1.1.8 Locus Chr. 2 q24.1 Glycerol-3-phosphate dehydrogenase GPDH is an enzyme that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate aka glycerone phosphate, outdated. Older terms for glycerol-3-phosphate dehydrogenase include alpha glycerol-3-phosphate dehydrogenase alphaGPDH and glycerolphosphate dehydrogenase GPDH. However, glycerol-3-phosphate dehydrogenase is not the same as glyceraldehyde 3-phosphate dehydrogenase GAPDH whose substrate is an aldehyde not an alcohol. Contents 1 Reaction 2 Glycerol-3-phosphate shuttle 3 See also 4 External links 5 References 6 External links Reaction The reaction catalyzed by cytosolic GPDH is as follows: Glycerol-3-phosphate shuttle Main article: Glycerol phosphate shuttle The cytosolic together with the mitochondrial glycerol-3-phosphate dehydrogenase work in concert. Oxidation of cytoplasmic NADH by the cytosolic form of the enzyme creates glycerol-3-phosphate from dihydroxyacetone phosphate. Once the Glycerol-3-phosphate has moved through the Outer Mitochondrial Membrane it can then be oxidised by a separate isoform of glycerol-3-phosphate dehydrogenase. This differ as it is instead FADH2 linked. As a result there is a net loss in energy, comparable to 1 ATP. Illustrated here 1. See also substrate pages: glycerol 3-phosphate, dihydroxyacetone phosphate related topics: glycerol phosphate shuttle, creatine kinase, glycolysis, gluconeogenesis External links equivalent entries: MeSH alphaGPDH and GPDH References IUBMB entry for 1.1.1.8 BRENDA references for 1.1.1.8 Recommended. PubMed references for 1.1.1.8 PubMed Central references for 1.1.1.8 Google Scholar references for 1.1.1.8 External links Yeast genome database GO term: GPDH enzyme no. -2053504966 at GPnotebook IUBMB entry for 1.1.1.8 KEGG entry for 1.1.1.8 BRENDA entry for 1.1.1.8 NiceZyme view of 1.1.1.8 EC2PDB: PDB structures for 1.1.1.8 PRIAM entry for 1.1.1.8 PUMA2 entry for 1.1.1.8 IntEnz: Integrated Enzyme entry for 1.1.1.8 MetaCyc entry for 1.1.1.8 Atomic-resolution structures of enzymes belonging to this class This EC 1.1.1 enzyme-related article is a stub. This biochemistry article is a stub. v d e Oxidoreductases: alcohol oxidoreductases EC 1.1 1.1.1 NAD/NADP acceptor Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta HSD11B1, HSD11B2 - 3 Beta 3-beta-HSD - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase - L-threonine dehydrogenase 1.1.2 cytochrome acceptor Mannitol dehydrogenase cytochrome - D-lactate dehydrogenase cytochrome - D-lactate dehydrogenase cytochrome c-553 1.1.3 oxygen acceptor Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase 1.1.4 disulfide as acceptor Vitamin K epoxide reductase - Vitamin-K-epoxide reductase warfarin-insensitive 1.1.5 quinone/similar acceptor Quinoprotein glucose dehydrogenase 1.1.99 other acceptors Choline dehydrogenase Retrieved from http://en..org/wiki/Glycerol-3-phosphate_dehydrogenase Categories: Genes on chromosome 12 | Genes on chromosome 2 | EC 1.1.1 stubs | EC 1.1.1 | Biochemistry stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Español Italiano This page was last modified on 19 August 2008, at 22:00
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