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20-September-2008 09:55:48 - Imidazoline receptor Imidazoline receptors are receptors for clonidine and other imidazolines.1 Contents 1 Classes 2 Pharmacology 3 See also 4 References 5 External links Classes There are three classes of imidazoline receptors:1 I1 receptor - mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, NISCH or IRAS, imidazoline receptor antisera selected I2 receptor - an allosteric binding site of monoamine oxidase I3 receptor - regulates insulin secretion from pancreatic beta cells Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstream eicosanoids.2 In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis is induced. The I1-imidazoline receptor may belong to the neurocytokine receptor family, since its signaling pathways are similar to those of interleukins.2 Pharmacology Agonists of these receptors include the antihypertensive moxonidine, while antagonists include idazoxan. See also imidazoline NISCH References ^ a b Head GA, Mayorov DN January 2006. Imidazoline receptors, novel agents and therapeutic potential. Cardiovasc Hematol Agents Med Chem 4 1: 17-32. PMID 16529547. ^ a b Ernsberger P June 1999. The I1-imidazoline receptor and its cellular signaling pathways. Ann. N. Y. Acad. Sci. 881: 35-53. PMID 10415895. External links MeSH Imidazoline+Receptors Tablets This pharmacology-related article is a stub. v d e Antihypertensives C02 and diuretics C03 Sympatholytic agents Centrally acting/antiadrenergics α2 agonist Clonidine, Guanfacine, Methyldopa imidazoline receptor agonist Moxonidine, Rilmenidine adrenergic uptake inhibitor Rescinnamine, Reserpine Ganglion-blocking/nicotinic antagonist Mecamylamine, Trimethaphan Peripherally acting/antiadrenergics α1 blockers: Prazosin Indoramin Trimazosin Doxazosin Urapidil Guanidine derivatives: Betanidine Guanethidine Guanoxan Debrisoquine Guanoclor Guanazodine Guanoxabenz Vasodilators Diazoxide hydrazinophthalazine Hydralazine, Dihydralazine, Endralazine, Cadralazine Minoxidil Nitroprusside Phentolamine Other antihypertensives serotonin antagonist Ketanserin endothelin receptor antagonist Bosentan, Ambrisentan, Sitaxsentan MAOI Pargyline THI Metirosine Diuretics Low ceiling Thiazides at DCT Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Chlorothiazide Polythiazide Trichlormethiazide Cyclopenthiazide Methyclothiazide Cyclothiazide Mebutizide Sulfonamides Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone Other Mersalyl Theobromine Cicletanine osmotic Mannitol, Urea carbonic anhydrase inhibitor at PT Acetazolamide High ceiling Loop diuretic at AL Bumetanide, Furosemide, Torasemide, Ethacrynic acid Potassium-sparing at CD ESC blockers Amiloride, Triamterene aldosterone antagonists Spironolactone, Eplerenone, Potassium canrenoate, Canrenone Retrieved from http://en..org/wiki/Imidazoline_receptor Categories: Pharmacology stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch This page was last modified on 15 August 2008, at 11:0
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