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News About Indapamide

20-September-2008 09:55:49 - Indapamide Indapamide Systematic IUPAC name 4-chloro-N-2-methyl-2,3-dihydroindol-1-yl- 3-sulfamoyl-benzamide Identifiers CAS number 26807-65-8 ATC code C03BA11 PubChem 3702 DrugBank APRD01031 Chemical data Formula C16H16ClN3O3S Mol. mass 365.835 g/mol Pharmacokinetic data Bioavailability ? Protein binding 71-79% Metabolism Hepatic Half life 14-18 hours Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes Oral Indapamide is a non-thiazide sulphonamide diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as edema caused by congestive heart failure. Indapamide is marketed as Natrilix SR sustained release. Combination preparations with perindopril an ACE inhibitor antihypertensive are also available. Contents 1 Form and composition 2 Indications 3 Dosage and administration 4 Contraindications 5 Interactions 6 Precautions 7 Adverse effects 8 Overdosage Form and composition Each sustained-release coated tablet contains 1.5 mg of 1-4-chloro-3-sulfamyl-benzamido-2-methylindoline or indapamide hemihydrate. Indications Essential hypertension. Dosage and administration One tablet daily. Contraindications Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe renal failure, hepatic encephalopathy or severe hepatic failure and hypokalemia low blood potassium levels. There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding. Interactions Caution is advised in the combination of indapamide with lithium and nonantiarrhythmic drugs causing wave burst arrhythmia astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine. Precautions Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout. Adverse effects Commonly reported adverse events are hypokalemia low potassium levels, fatigue, orthostatic hypotension blood pressure decrease on standing up and allergic manifestations. Overdosage Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities. v d e Antihypertensives C02 and diuretics C03 Sympatholytic agents Centrally acting/antiadrenergics α2 agonist Clonidine, Guanfacine, Methyldopa imidazoline receptor agonist Moxonidine, Rilmenidine adrenergic uptake inhibitor Rescinnamine, Reserpine Ganglion-blocking/nicotinic antagonist Mecamylamine, Trimethaphan Peripherally acting/antiadrenergics α1 blockers: Prazosin Indoramin Trimazosin Doxazosin Urapidil Guanidine derivatives: Betanidine Guanethidine Guanoxan Debrisoquine Guanoclor Guanazodine Guanoxabenz Vasodilators Diazoxide hydrazinophthalazine Hydralazine, Dihydralazine, Endralazine, Cadralazine Minoxidil Nitroprusside Phentolamine Other antihypertensives serotonin antagonist Ketanserin endothelin receptor antagonist Bosentan, Ambrisentan, Sitaxsentan MAOI Pargyline THI Metirosine Diuretics Low ceiling Thiazides at DCT Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Chlorothiazide Polythiazide Trichlormethiazide Cyclopenthiazide Methyclothiazide Cyclothiazide Mebutizide Sulfonamides Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone Other Mersalyl Theobromine Cicletanine osmotic Mannitol, Urea carbonic anhydrase inhibitor at PT Acetazolamide High ceiling Loop diuretic at AL Bumetanide, Furosemide, Torasemide, Ethacrynic acid Potassium-sparing at CD ESC blockers Amiloride, Triamterene aldosterone antagonists Spironolactone, Eplerenone, Potassium canrenoate, Canrenone Retrieved from http://en..org/wiki/Indapamide Categories: Thiazides Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Hrvatski Magyar Italiano 日本語 Polski This page was last modified on 5 June 2008, at 15:44

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