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20-September-2008 09:55:54 - ICAM4 Redirected from Landsteiner-Weiner antigen system Jump to: navigation, search Intercellular Adhesion Molecule-4 Landsteiner-Weiner blood system Identifiers Symbol ICAM-4 Alt. Symbols LW Entrez 3386 HUGO 5347 OMIM 111250 RefSeq NM_001039132 UniProt Q14773 Other data Locus Chr. 19 p13.2-cen The LW blood system was first described by Landsteiner and Weiner in 1940. It was often confused with the Rh system, not becoming a separate antigen system until 1982. The LW and RhD antigens are genetically independent though they are phenotypically related and the LW antigen is expressed more strongly on RhD positive cells than on RhD negative cells. In most populations, the antithetical LW antigens, LWa and LWb are present as very high and very low frequency, respectively. LW antigens reside on a 40- to 42-kDa red cell membrane glycoprotein of about Mr 40 000 named CD242. The LW locus is located on chromosome 19p13.3. The LW glycoprotein has recently been renamed ICAM-4 due to its similarity to intercellular adhesion molecule, although exactly which integrins bind to ICAM-4 is subject to controversy. The function of ICAM-4 is not fully understood but appears to be restricted to erythroid cells. During in vitro erythropoesis, LW appears at either the erythroid colony forming stage or later at the proerythroblast stage. A vital part of erythropoesis is the clustering of erythroblasts around bone marrow macrophages to form erythroblastic islands. The erythroblast is then able to remove its nucleus, which is in turn ingested and broken down by the macrophages, to become a mature erythrocyte. During this process ICAM-4 binds to VLA-4, an erythroblast binding site, on adjacent erythroblasts and to αv integrins on macrophages to help stabilise the erythroblastic islands. The binding of red cells to macrophages in the spleen by ICAM-4 could also play a part in the removal of senescent red cells. Despite the functional aspects of ICAM-4, its apparent absence in LWa-b- and Rhnull phenotypes does not appear to lead to any obvious pathological effects. ICAM-4 expression is elevated on sickle red cells and its binding to αv integrins on the endothelial cells may cause the pain associated with sickle cell crises. Auto anti-LW is not uncommon as an autoantibody but usually presents with transient suppression of the LW antigen in genetically LW+ individuals, and so appears to be an alloantibody. True alloanti-LW is a very rare occurrence, with only two known examples of alloanti-LWab, produced by patients with an LWa-b- phenotype. Anti-LW can be present as a clinically insignificant autoantibody and not be associated with increased red cell destruction. Anti-LW has also been associated with cases of warm type autoimmune haemolytic anaemia, Levine suggested that it was the most common antibody in cases of AIHA with a positive Coombs test. Haemolytic disease of the newborn HDFN due to alloanti-LW is described as mild and very rare, even the very potent anti-LWab of one known patient caused minimal evidence of HDFN in her three pregnancies. To date auto anti-LW has only been implicated as the cause of one case of HDFN, which is currently under investigation. 1 2 3 4 5 6 References ^ Daniels G. Human Blood groups. 2nd ion. Oxford. Blackwell Publishing Ltd. 2002. ^ Gorst DW, Rawlinson VI, Merry Ah, et al. Positive Direct Antiglobulin Test in normal individuals. Vox Sang. 1980; 38: 99-105. ^ Vos GH, Petz LD, Garratty G, Fudenberg HH. Autoantibodies in Acquired Hemolytic Anemia with Special Reference to the LW system. Blood. Vol 42. No.3 September. 1973; 445-453. ^ Daniels G, Poole J, de Silva M, et al. The clinical significance of blood group antibodies. Transfusion Medicine. 2002. 12; 287-295. ^ Klein HG, Anstee DJ. Mollison's Blood Transfusion in Clinical Medicine. 11th ion. Oxford. Blackwell Publishing Ltd. 2005. ^ Hoffbrand Av, Pettit JE, Moss PAH. Essential Haematology. 4th ion. Oxford. Blackwell Science Ltd. 2001. v d e Transfusion medicine General concepts Apheresis Plasmapheresis, Plateletpheresis, Leukapheresis - Blood transfusion - Coombs test - Cross-matching - Exchange transfusion - International Society of Blood Transfusion - Intraoperative blood salvage - ISBT 128 - Transfusion reactions Human blood group systems - Blood type ABO - Chido-Rodgers - Colton - Cromer - Diego - Dombrock - Duffy - Gerbich - GIL - Hh - Ii - Indian - JMH - Kell Xk - Kidd - Knops - LW - Lewis - Lutheran - MNS - OK - P - Raph - Rh - Scianna - T-Tn - Xg - Yt - Other Blood products Blood donation - Blood substitutes - Cryoprecipitate - Platelets - Plasma - Red blood cells - Whole blood v d e Membrane proteins: cell adhesion molecules IgSF N-CAM Myelin protein zero - ICAM 1, 4 - VCAM-1 - PE-CAM - L1-CAM Cadherins Desmoglein - T-cadherin - protocadherin - CDH1 - CDH2 - CDH3 - CDH4 - CDH5 - CDH6 - CDH8 - CDH11 - CDH12 - CDH15 - CDH16 - CDH17 Selectins E-selectin - L-selectin - P-selectin Integrins LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa Note: integrins not always classified as CAMs Other Carcinoembryonic antigen - CD22 - CD24 - CD44 - CD146 - CD164 Retrieved from http://en..org/wiki/ICAM4 Categories: Genes on chromosome 19Hidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 20 July 2008, at 11:07
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