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20-September-2008 09:55:57 - Levocabastine Levocabastine Systematic IUPAC name 1-4-cyano-4-4-fluorophenyl-cyclohexyl- 3-methyl-4-phenyl-piperidine-4- carboxylic acid Identifiers CAS number 79516-68-0 ATC code R01AC02 S01GX02 PubChem 54385 DrugBank APRD01069 Chemical data Formula C26H29FN2O2 Mol. mass 420.519 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life 3 Excretion ? Therapeutic considerations Pregnancy cat. B3AU CUS Legal status ℞ Prescription only Routes Ophthalmic, intranasal1 Levocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastine was discovered at Janssen Pharmaceutica in 1979. References Pipkorn U, Bende M, Hedner J, Hedner T., A double-blind evaluation of topical levocabastine, a new specific H1 antagonist in patients with allergic conjunctivitis, Allergy. 1985 Oct;407:491-6. RxList 2004. Livostin Online, Description, Chemistry, Ingredients - Levocabastine. LIVOSTIN. RxList Inc. Retrieved on 9 October 2005. Novartis Pharmaceuticals March 2002. LIVOSTIN PDF. Retrieved on August 20, 2006. ^ RxMed: Pharmaceutical Information - LIVOSTIN NASAL SPRAY. Retrieved on 13 November 2005. v d e Histamine antagonists H1 or non-selective Alkylamines Bepotastine Bamipine Brompheniramine Chlorpheniramine Dexbrompheniramine Dexchlorpheniramine Dimethindene Metron S Pheniramine Pyrrobutamine Talastine Thenaldine Tolpropamine Triprolidine Ethanolamines Aminoalkyl ethers Bietanautine Bromazine/Bromodiphenhydramine Carbinoxamine Chlorphenoxamine Clemastine Diphenylpyraline Diphenhydramine Doxylamine Embramine p-Methyldiphenhydramine Moxastine Orphenadrine Phenyltoloxamine Setastine Ethylenediamines Chloropyramine Chlorothen Histapyrrodine Methafurylene Mepyramine Methapyrilene Pyrilamine Talastine Thenyldiamine Thonzylamine Tripelennamine Pyribenzamine Phenothiazine Tricyclics Ahistan Etymemazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Thiazinamium Other Tricyclics Azatadine Clobenzepam Cyproheptadine Deptropine Isothipendyl Loratidine Piperazine Buclizine Chlorcyclizine Cinnarizine Clocinizine Hydroxyzine Niaprazine Oxatomide Benzhydryl compounds Cyclizine, Meclizine Others including selective, 2nd gen, 3rd gen Antazoline Astemizole Azatadine Azelastine Bepottastine Bamipine Cetoxine Clemizole Clobenztropine Deptropine Desloratadine Dimebon Ebastine Emedastine Epinastine Ketotifen Levocabastine Loratadine Mebhydrolin Mizolastine Phenindamine Pimethixene Pyrrobutamine Rupatadine Thenalidine Tritoqualine Alkylamine Acrivastine Tricyclic Olopatadine Piperazine Levocetirizine, Cetirizine Benzhydryl compounds Fexofenadine, Terfenadine H2 Cimetidine Famotidine Ranitidine Roxatidine Lafutidine Niperotidine Nizatidine H3 A-349,821 ABT-239 Burimamide Ciproxifan Clobenpropit Conessine Impentamine Iodophenpropit Thioperamide VUF-5681 H4 JNJ 7777120 Thioperamide VUF-6002 v d e Decongestants and other nasal preparations R01 Topical Sympathomimetics, plain Cyclopentamine - Ephedrine - Phenylephrine - Oxymetazoline - Tetryzoline - Xylometazoline - Naphazoline - Tramazoline - Metizoline - Tuaminoheptane - Fenoxazoline - Tymazoline - Epinephrine Antiallergic agents, excluding corticosteroids Spaglumic acid histamine antagonists Levocabastine, Antazoline, Thonzylamine mast cell stabilizer some are also antihistamines Cromoglicic acid, Nedocromil, Azelastine, Olopatadine Corticosteroids Beclometasone - Prednisolone - Dexamethasone - Flunisolide - Budesonide - Betamethasone - Tixocortol - Fluticasone - Mometasone furoate - Triamcinolone - Ciclesonide Other nasal preparations Calcium hexamine thiocyanate - Retinol - Ipratropium bromide - Ritiometan - Mupirocin - Hexamidine - Framycetin Systemic use: Sympathomimetics Phenylpropanolamine - Pseudoephedrine - Phenylephrine Tablets This pharmacology-related article is a stub. Retrieved from http://en..org/wiki/Levocabastine Categories: Antihistamines | Pharmacology stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 19 August 2008, at 00:34
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