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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 09:55:50 - Lisuride Lisuride Systematic IUPAC name 1,1-diethyl-3-6aR,9S-7-methyl- -4,6,6a,7,8,9-hexahydroindolo4,3-fgquinolin-9-ylurea Identifiers CAS number 18016-80-3 ATC code G02CB02 N02CA07 PubChem 28864 DrugBank APRD00636 Chemical data Formula C20H26N4O Mol. mass 338.447 g/mol Pharmacokinetic data Bioavailability 10-20% for lisuride hydrogenmaleate Protein binding about 15% Metabolism Hepatic Half life 2 hours Excretion renal and biliary in equal amounts Therapeutic considerations Pregnancy cat. ? Legal status Prescription only Routes Oral, subcutaneous, transdermal Lisuride brand name in Germany Dopergin is an anti-Parkinson's drug of the iso-ergoline class, chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride is described as free base see table on the right and as hydrogenmaleate salt. Lisuride is used to lower prolactin and, in low doses, to prevent migraine attacks. The use of lisuride as initial anti-Parkinsonian treatment has been advocated, delaying the need for levodopa until lisuride becomes insufficient for controlling the Parkinsonian disability. Preliminary trials suggest that the dermal application of lisuride may be useful in the treatment of Parkinson's disease. Lisuride is not currently available in the US. Contents 1 Mode of action 2 Commercial names 3 History 4 Indications 5 See also Mode of action Lisuride is a dopamine agonist. Commercial names Name Country of Use Arolac France Cuvalit Germany Dipergon Greece Dopergine Germany, Spain, France, China Dopergine Belgium Lysenyl Forte Czech Republic, Slovakia Prolacam Australia Revanil UK History Synthesis of lisuride was first described in 1960. Indications Parkinson's Disease See also Dopamine receptor v d e Serotonin agonists 5-HT1 5-HT1A Binospirone, Buspirone, Gepirone, Tandospirone, Flesinoxan, Ipsapirone, Urapidil 5-HT1D Almotriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Sumatriptan, Zolmitriptan 5-HT2 Dexfenfluramine - Dimethyltryptamine - Lisuride - Lysergic acid diethylamide - Mescaline 5-HT3 Quipazine 5-HT4 BIMU-8 - Cisapride - Mosapride - Tegaserod - Zacopride v d e Ergolines Lysergic acid derivatives Bromocriptine, Cabergoline, Ergine, Ergonovine, Ergotamine, Lysergic acid, Lysergol, LSD, D-Lysergic acid hydroxyethylamide, Lisuride, Methergine, Methysergide, Pergolide Hallucinogenic lysergamides AL-LAD, ALD-52, BU-LAD, CYP-LAD, DAL, DAM-57, Ergonovine, ETH-LAD, LAE-32, LSD, LPD-824, LSM-775, D-Lysergic acid N-α-hydroxyethylamide, Methylergonovine, MLD-41, PARGY-LAD, PRO-LAD Other ergolines Ergoline Natural sources Argyreia nervosa, Claviceps spp., Ipomoea tricolor, Ipomoea violacea, Rivea corymbosa v d e Other gynecologicals G02C Sympathomimetics, labour repressants Ritodrine - Buphenine - Fenoterol Prolactin inhibitors Bromocriptine - Lisuride - Cabergoline - Quinagolide - Metergoline Anti-inflammatory products for vaginal administration Ibuprofen - Naproxen - Benzydamine - Flunoxaprofen Other gynecologicals Atosiban v d e Antimigraine preparations N02C Ergot alkaloids Dihydroergotamine Ergotamine Methysergide Lisuride Corticosteroid derivatives Flumedroxone Selective serotonin 5-HT1 agonists Triptans Almotriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Sumatriptan, Zolmitriptan Other antimigraine preparations Pizotifen Clonidine Topiramate Amidrine Iprazochrome Dimetotiazine Oxetorone Dotarizine Lomerizine v d e Anti-parkinson drugs: dopaminergic agents N04B Dopa and derivatives Droxidopa Levodopa Melevodopa Etilevodopa Adamantane derivatives Amantadine Dopamine agonists A-412,997 Apomorphine Bromocriptine Cabergoline Dihydrexidine Dihydroergocryptine mesylate Fenoldopam Lisuride Pergolide Piribedil Pramipexole Propylnorapomorphine Quinpirole Ropinirole Rotigotine SKF 38393 SKF 82958 MAOIs B Selegiline Rasagiline COMT inhibitors Entacapone Tolcapone Other Budipine dopa decarboxylase inhibitor Carbidopa Retrieved from http://en..org/wiki/Lisuride Categories: Dopamine agonists | Serotonin receptor agonists | Ureas Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Esperanto This page was last modified on 24 July 2008, at 04:46
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