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20-September-2008 09:55:56 - MDPV MDPV Systematic IUPAC name 1-benzod1,3dioxol-5-yl-2-pyrrolidin-1-ylpentan-1-one Identifiers CAS number 24622-62-6 ATC code ? PubChem 20111961 Chemical data Formula C16H21NO3 Mol. mass 275.35 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status unscheduled Routes oral, insufflation, intravenous Methylenedioxypyrovalerone, also known as MDPK or 1-3,4-methylenedioxyphenyl-2-pyrrolidinyl-pentan-1-one, commonly known by the street name Soniccitation needed is a stimulant drug which acts as a norepinephrine and dopamine reuptake inhibitor, reportedly with four times the potency of methylphenidate. 1 This compound is reported to be used as a stimulant and an aphrodisiac. It has no history of medical use but has been sold as a designer drug for recreational use. Contents 1 Appearance and effects 2 Legality 3 References 4 CAS Data 5 External links Appearance and effects The substance appears as a pure white to light-brown, significantly hydrophilic crumbly powder with a slight odour, at least as has been available from the few online sellers who offered it. It appears to darken slightly in colour and take on a potato-tuber-like odor if exposed to air for any significant length of time.2 Early on, an impurity was identified and said to consist of pyrrolidine, and that could account for its earthy odour when left uncapped. It has also been observed to rapidly degrade and lose potency when in solution. Subjective effects include CNS stimulation, euphoria, hypersexuality, agitation/anxiety and insomnia, with a duration of three to six hours. High doses have been observed to cause intense, prolonged anxiety attacks in stimulant-intolerant users, and there are anecdotal reports of addiction at higher doses or more frequent dosing intervals. MDPV has been remarked about more than once for its powers as an aphrodisiac, which have been said to rival those of methamphetamine when dosed correctly 3. However, it is apparently not as powerful as methamphetamine as far as general effects go, and may be safer there have been no reports of death or disability as a result of abuse posted on research chemical related internet forums, and these tend to surface rapidly when a substance poses immediate dangers. MDPV is the 3,4-methylenedioxy ring-substituted analogue of the appetite suppressant pyrovalerone, however despite its apparent structural similarity to the untrained eye, the effects of MDPV bear little resemblance to other methylenedioxyphenylalkylamine derivatives such as MDMA and methylone, instead producing purely stimulant effects with no empathogenic qualities. Extended binges on MDPV have also been reported to produce severe come-down syndrome similar to that of methamphetamine and characterised by depression, lethargy, headache, anxiety and in some cases severely bloodshot eyes. Kidney and liver pain has also been reported when MDPV is used for extended periods.4 5 6 Legality MDPV is not specifically listed as an illegal drug in any country, but its structural similarity to illegal drugs of abuse makes it likely that it would be considered a controlled substance analogue in several countries such as the USA, Australia and New Zealand. Other analogues derived from alpha-pyrrolidinopropiophenone include the 4-methyl analogue pyrovalerone, as well as analogues with no substitution on the aromatic ring, and analogues with between 3 and 6 carbons on the alkyl chain. 7 These compounds have been reported as stimulants of abuse mainly in Germany and other European countries since the early 2000s, but they have remained little known and rarely used or encountered by law enforcement. 8 MDPV is enjoying a minor resurgence on the research chemical market as of late, and the substance may be illegal in the USA as an analog of a Schedule V controlled substance. References ^ 1-3,4-Methylenedioxyphenyl-2-pyrrolidino-1-alkanones as stimulants. Boehringer Ingelheim G.m.b.H.. Brit. 1969, 7 pp. CODEN: BRXXAA GB 1149366 19690423 Patent written in English. Priority: DE 19650523. CAN 72:21608 AN 1970:21608 CAPLUS ^ 1-3,4-methylenedioxy-phenyl-2-pyrrolidin-1-yl-pentan-1-one - Bluelight ^ Bluelight - View Single Post - The MDPV Discussion Thread ^ 1-3,4-methylenedioxy-phenyl-2-pyrrolidin-1-yl-pentan-1-one - Bluelight ^ Erowid Experience Vaults: MDPV - Diet MDE - 47047 ^ MDPV Experience Reports - Drugs Forum ^ Meltzer PC, Butler D, Deschamps JR, Madras BK. 1-4-Methylphenyl-2-pyrrolidin-1-yl-pentan-1-one Pyrovalerone analogues: a promising class of monoamine uptake inhibitors. Journal of Medicinal Chemistry. 2006 Feb 23;494:1420-32. ^ Springer D, Fritschi G, Maurer HH. Metabolism of the new designer drug alpha-pyrrolidinopropiophenone PPP and the toxicological detection of PPP and 4'-methyl-alpha-pyrrolidinopropiophenone MPPP studied in rat urine using gas chromatography-mass spectrometry. Journal of Chromatography B, Analytical Technologies in the Biomedical Life Sciences. 2003 Nov 5;7962:253-66. CAS Data CAS number 687603-66-3 MDPV freebase; 24622-62-6 MDPV hydrochloride External links Pubchem - similar compounds J. Med. Chem Abstract Erowid MDPV Vault Bluelight.ru - Main MDPV discussion thread Additional discussion on Bluelight v d e Stimulants Alkylamines Cyclopentamine Geranamine Isometheptene Octodrine Propylhexedrine Tuamine Alphapyrrolidinylalkiophenones α-PPP MDPPP MDPV MPBP MPHP MPPP MOPPP Pyrovalerone Cholinergics ABT-089 ABT-418 Anabasine Arecoline Cotinine Cytisine Dianicline Epibatidine Epiboxidine GTS-21 Ispronicline Nicotine Rivanicline Tebanicline Varenicline Convulsants Bicuculline DMCM Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil Carphedon Modafinil Phenethylamines 4-Bromomethcathinone 4-Fluoroamphetamine 4-Fluoromethamphetamine 4-Fluoromethcathinone 4-Methylmethcathinone 4-MTA Aletamine Amfepentorex Amphechloral Amphetamine Dextroamphetamine, Adderall Amphetaminil Benzphetamine Bupropion Cathinone Chlorphentermine Clenbuterol Clobenzorex Clortermine Diethylpropion Dimethoxyamphetamine Dimethylamphetamine Dimethylcathinone Ephedrine Epinephrine Ethcathinone Ethylamphetamine Fenethylline Fenfluramine Fenproporex Fludorex Furfenorex Levomethamphetamine Lisdexamfetamine MDMA Mefenorex Methamphetamine Methcathinone Methoxyphedrine Methylone Octopamine Ortetamine Parahydroxyamphetamine PCA PIA PMA PMEA PMMA PPAP Phendimetrazine Phenmetrazine Phentermine Phenylephrine Phenylpropanolamine Propylamphetamine Pseudoephedrine Selegiline Synephrine Tiflorex Xylopropamine Phenylaminooxazoles 4-Methyl-aminorex Aminorex Clominorex Fenozolone Fluminorex Pemoline Thozalinone Piperazines 2C-B-BZP BZP GBR-12783 GBR-12935 GBR-13069 GBR-13098 GBR-13119 MeOPP MBZP Vanoxerine Piperidines 2-Benzylpiperidine Desoxypipradrol Diphemethoxidine Ethylphenidate HDMP-28 --Methyl-1-methyl-4β-2-naphthylpiperidine-3β-carboxylate Methylphenidate Dexmethylphenidate Nocaine Phacetoperane Pipradrol Tropanes 3α-Bis-4-fluorophenylmethoxytropane 3α-4-Chlorophenylphenylmethoxytropane 3-Pseudotropyl-4-fluorobenzoate Altropane IACFT Brasofensine CFT WIN 35,428 β-CIT RTI-55 Cocaethylene Cocaine β-CPPIT Dichloropane RTI-111 Difluoropine FE-β-CPPIT FP-β-CPPIT PIT PTT RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-121 IPCIT RTI-126 RTI-150 RTI-171 RTI-177 RTI-336 Tesofensine Troparil β-CPT, WIN 35,065-2 WF-23 WF-33 WF-60 Xanthines Aminophylline Caffeine Dimethazan Paraxanthine Theobromine Theophylline Others Amineptine Bemegride Benzydamine BPAP Bromantane BTQ Clofenciclan Cypenamine Cyprodenate Diclofensine Dimethocaine Diphenyl prolinol Ethamivan Fencamfamine Feprosidnine Gilutensin GYKI-52895 Hexacyclonate Indanorex Indatraline LR-5182 Mazindol Mesocarb Naphthylisopropylamine Nikethamide Nomifensine Phthalimidopropiophenone Prolintane Sibutramine Yohimbine Zylofuramine See also Sympathomimetic amines Retrieved from http://en..org/wiki/MDPV Categories: Stimulants | Dopamine reuptake inhibitorsHidden categories: All articles with statements | Articles with statements since June 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Polski This page was last modified on 21 August 2008, at 05:0
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