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20-September-2008 09:55:52 - MMRV vaccine The MMRV vaccine combines the attenuated virus MMR measles, mumps, rubella vaccine with the addition of chickenpox vaccine. One MMRV vaccine, approved in 2005 for use in the United States by the Food and Drug Administration for children ages twelve months through twelve years, is called ProQuad. The vaccine is administered via injection for protection against four viral infectious diseases, and contains about ten times more chickenpox vaccine than the Varivax brand varicella vaccine. The quadruple vaccine, marketed by pharmaceutical giant Merck, is generally administered to children around the age of one year. A MMRV vaccine called Priorix Tetra 1 by GlaxoSmithKline, targeted at children 1-2 years of age, has been approved in Germany and Australia. 2 Contents 1 Motivation 2 Availability 3 Contraindications 4 Adverse events 5 References 6 External links Motivation The World Health Organization recommends vaccinating against measles, mumps, rubella German measles, and varicella chickenpox because the risks of these diseases far outweigh the risks of vaccinating against them. In particular, the World Health Organization recommends varicella vaccination in countries where the vaccine is affordable, the disease is a relatively important problem, and high and sustained coverage can be achieved. The U.S. and a few other countries have widely implemented this. MMR and varicella vaccine are given at roughly the same time and a booster injection is recommended for both. The MMRV vaccine, a combined MMR and varicella vaccine, simplifies administration of the vaccines.3 Availability In May, 2007, the manufacturer Merck announced that, due to manufacturing problems in the chickenpox component, the Merck vaccine ProQuad is not available. In August 2007, Merck announced that they did not know whether ProQuad would be made available in 2008 due to an issue with its bulk manufacturing process, but their goal was to restore its availability as soon as possible.4 Contraindications For individuals who are moderately or severely ill, it is generally recommended that they wait until after recovery before getting ProQuad. No such precautions are recommended for minor illnesses, such as a cold. It is recommended that aspirin or aspirin containing products be avoided for at least six weeks after receiving ProQuad vaccine. A serious condition called Reye's Syndrome has been reported in patients with chicken pox. Individuals should not receive ProQuad without first consulting their doctor if there is a history of a life-threatening allergic reaction to gelatin, eggs, the antibiotic neomycin, or a previous MMR or chicken pox vaccine. Doctors are advised to be aware of whether or not a patient has HIV, AIDS or another disease that affects the immune system, is taking a medication that affects the immune system, has cancer, a fever or active untreated tuberculosis, is receiving cancer treatment, or has ever had a low platelet count a blood disorder. Adverse events Rare but serious adverse events reported following ProQuad vaccination include allergic reactions, including swelling of the lips, tongue, or face; difficulty breathing or closing of the throat; hives; paleness; weakness; dizziness; a fast heart beat; deafness; long-term seizures, coma, or lowered consciousness; permanent brain damage; seizures jerking or staring caused by fever; or temporary low platelet count. According to information from CDC, MMRV vaccine has been associated with higher rates of fever up to about 1 person in 5 and measles-like rash about 1 person in 20 compared with MMR and varicella vaccines given separately.5 References ^ GSK: Priorix Tetra Studies ^ GlaxoSmithKline PLC GSK Full Description | Stocks | Reuters.com ^ Vesikari T, Sadzot-Delvaux C, Rentier B, Gershon A 2007. Increasing coverage and efficiency of measles, mumps, and rubella vaccine and introducing universal varicella vaccination in Europe: a role for the combined vaccine. Pediatr Infect Dis J 26 7: 632-8. doi:10.1097/INF.0b013e3180616c8f. PMID 17596807. ^ Netzer TM 2007-08-28. Dear valued customer PDF. Retrieved on 2007-09-19. ^ cdc.gov - Possible Side-effects from Vaccines External links CDC.gov Licensure of a Combined Live Attenuated Measles, Mumps, Rubella, and Varicella Vaccine Merck ProQuad FDA.gov - Product Approval Information - Licensing Action: Measles, Mumps, Rubella and Varicella Virus Vaccine Live ProQuad Merck Co', Food and Drug Administration September 6, 2005 MedicalNewsToday.com - 'Cochrane Library publishes the most thorough survey of MMR vaccination data', Medical News Today v d e Vaccines, Vaccination, Immunization, and Inoculation see also artificial induction of immunity Development Adjuvants Cancer vaccines DNA vaccination HIV Live vector vaccine Models Timeline Trial Administration Global: GAVI Policy Schedule Vaccine injury USA: ACIP VAERS VSD Vaccine court Vaccines live Anthrax BCG tuberculosis Flu MMR MMRV PolioOPV Rotavirus Smallpox Varicella Yellow fever Inactivated/toxoid inactivated virus: Flu HAV PolioIPV inactivated bacteria/toxoid: DTwP conjugate: Hib PCV Other subunit: Anthrax DTaP HPV recombinant DNA: HBV other: Anthrax PPV Controversy General A-CHAMP MMR NCVIA Pox party Safe Minds Thiomersal See also List of vaccine topics Epidemiology Eradication of infectious diseases Retrieved from http://en..org/wiki/MMRV_vaccine Categories: Pediatrics | Vaccines Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 22 April 2008, at 23:23
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