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20-September-2008 09:55:56 - MeOPP MeOPP is part of Pharmacology, a project to improve all Pharmacology-related articles. If you would like to help improve this and other pharmacology articles, please join the project. All interested ors are welcome. Stub This article has been rated as Stub-Class on the quality scale. MeOPP Systematic IUPAC name 1-4-methoxyphenylpiperazine Identifiers CAS number 38212-30-5 ATC code ? PubChem 269722 Chemical data Formula C11H16N2O Mol. mass 192.258 g/mol SMILES eMolecules PubChem Pharmacokinetic data Bioavailability ? Metabolism hepatic Half life ? Excretion renal Therapeutic considerations Pregnancy cat. ? Legal status Routes oral 4-methoxyphenylpiperazine Paraperazine, MeOPP, 4-MeOPP is a piperazine derivative with stimulant effects which has been sold as an ingredient in Party pills, initially in New Zealand and subsequently in other countries around the world. MeOPP has been found in vitro to inhibit monoamine re-uptake and stimulate their release. This is a mechanism of action shared with drugs of abuse such as amphetamines, and MeOPP produces somewhat similar effects although it is much less potent and is thought to have relatively insignificant abuse potential. 1 Piperazine derivatives such as TFMPP have also been shown to exert a major part of their mechanism of action as non-selective serotonin agonists, and MeOPP has also been demonstrated to act in this way. 2 MeOPP is anecdotally said to induce significantly less anxiety than similar piperazines, and is usually taken at doses between 120 - 200mg. It does not produce prominent stimulant effects, but is instead said to be relaxingcitation needed, however it is often mixed with stimulant piperazine derivatives such as BZP for a combined effect. Based on the recommendation of the EACD, the New Zealand government has passed legislation which placed BZP, along with the other piperazine derivatives TFMPP, mCPP, pFPP, MeOPP and MBZP, into Class C of the New Zealand Misuse of Drugs Act 1975. A ban was intended to come into effect in New Zealand on December 18th 2007, but the law change did not go through until the following year, and the sale of BZP and the other listed piperazines became illegal in New Zealand as of 1st of April 2008. An amnesty for possession and usage of these drugs will remain until October 2008, at which point they will become completely illegal.3 See also BZP mCPP TFMPP pFPP MBZP MDBZP 2C-B-BZP DBZP Party pills Piperazine External links References ^ Nagai F, Nonaka R, Satoh Hisashi Kamimura K. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. European Journal of Pharmacology. 2006 Dec 12; Epub ahead of print ^ Maurer HH, Kraemer T, Springer D, Staack RF. Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine ecstasy, piperazine, and pyrrolidinophenone types: a synopsis. Therapeutic Drug Monitoring. 2004 Apr; 262: 127-31. ^ Misuse of Drugs Classification of BZP Amendment Bill 2008 Tablets This pharmacology-related article is a stub. Retrieved from http://en..org/wiki/MeOPP Categories: Stub-Class pharmacology articles | Unknown-importance pharmacology articles | Pharmacology articles | Piperazines | Serotonin receptor agonists | Pharmacology stubsHidden categories: All articles with statements | Articles with statements since December 2007 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 22 May 2008, at 17:01
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