Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 09:55:56 - Methcathinone July 2007 Methcathinone Systematic IUPAC name 2-methylamino-1-phenyl-propan-1-one Identifiers CAS number 5650-44-2 49656-78-2 HCL 112117-24-5 S form 66514-93-0 S HCL ATC code ? PubChem 1576 Chemical data Formula C10H13NO Mol. mass 163.22 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion Urine Therapeutic considerations Pregnancy cat. ? Legal status Schedule IUS Routes Vaporized, insufflated, injected, orally Methcathinone 2-methylamino-propiophenone, α-methylamino-propiophenone is a psychoactive stimulant. It is sometimes used as a recreational drug and is considered to be addictive1. It is usually snorted, but can be smoked, injected, or taken orally. Methcathinone is currently a DEA Schedule I controlled substance in the United States. The C=O bond at the Rβ-position directly right of the benzene ring is slightly polar, and as a result the drug does not cross the lipid blood-brain barrier quite as well as amphetamine. Nevertheless, it is a potent CNS stimulant and dopamine reuptake inhibitor. Chronic high dosage use may result in acute mental confusion ranging from mild paranoia to psychosis. These symptoms typically disappear quickly if use is stopped. Unlike methamphetamine, methcathinone is not legal under any circumstances due to its classification as a Schedule I substance. In contrast, methamphetamine has certain medical uses such as treatment of morbid obesity, narcolepsy, and ADHD. Contents 1 History 2 Chemistry 3 Effects 4 Use and pharmacology 5 Street names 6 Addiction 7 Clinical use 8 See also 9 External links 10 References History Methcathinone was first synthesized in Germany in 1928. It was used in the Soviet Union during the 1930s and 1940s as an anti-depressant. Since the 1960s, methcathinone has been used as a recreational drug in the former Soviet Union. Circa 1994, the United States government recommended to the UN Secretary-General that methcathinone should be added to Schedule I of the Convention on Psychotropic Substances.2 Chemistry Methcathinone is very similar in structure to ethcathinone, rare cathinone analogue and cathinone, a stimulant alkaloid occurring in the shrub Catha edulis Khat, the synthetic stimulant methamphetamine, and other phenethylamines. Methcathinone has a single chiral carbon atom, thus yielding enantiomeric + and - forms. Methcathinone is most commonly made by the oxidation of ephedrine. Oxidation of ephedrine to methcathinone requires little chemistry experience, making it easy to synthesize. Potassium permanganate KMnO4 is most commonly used as the oxidant.3 Synthesizing methcathinone using either potassium permanganate or various chromates is considered undesirable because of the low yields and the high toxicity of these oxidants. A method that yields more methcathinone is oxidizing ephedrine with sodium hypochlorite.4 If done in a proper laboratory using the proper procedures, however, potassium permanganate can be a high-yielding reactant.3 Methcathinone as free base is very unstable; it easily loses its ketone status and converts back into an alcohol. Structurally, this occurs when the C=O bond at the Rβ-position is converted into a C-OH bond. In other words, basic methcathinone will turn into ephedrine, from which it was synthesized. Methcathinone acts on the body and brain much like methamphetamine and amphetamines do. Effects Methcathinone hydrochloride increases spontaneous rodent locomotor activity5, potentiates the release of dopamine from dopaminergic nerve terminals in the brain5, and causes appetite suppression.citation needed Users can easily forget to consume fluids and a state of thirst and dehydration is apparent. The effects of methcathinone are similar to those of methamphetamine, initially deemed to be less intense by the inexperienced user, and often more euphoric. The effects have been compared to those of cocaine, since it commonly causes hypertension elevated blood pressure and tachycardia elevated heart rate. Reported effects include: Feelings of euphoria Increased alertness Dilated pupils Rapid breathing Increased heart rate Inability to stop talking Increased empathy and sense of communication Both decreased and increased sexual function and desire Loss of cognitive ability relating to the distinction of relative importance of matters ie. one might spend days thinking that he or she is being productive but later realize that the activity and/or product was not even necessary The effects of methcathinone usually last from four to six hours. Use and pharmacology Methcathinone has very strong affinities for the dopamine transporter and the noradrenaline transporter. Its affinity for the serotonin transporter is less than that of methamphetamine.6 Anecdotal reports have provided some information on patterns of methcathinone use. The most common route of administration is via nasal insufflation snorting.citation needed Other routes of administration include oral ingestion, intravenous injection and smoking. Methcathinone binges resemble amphetamine binges in that the user may not sleep or eat, and takes in little in the way of liquids. The methcathinone binge is followed by a crash characterized by long periods of sleep, excess eating and, in some cases, depression.citation needed Injecting this substance has recently been associated with symptoms similar to those seen in patients with Parkinson's Disease Manganism due to the compound Manganese Dioxide which is a byproduct of synthesis with Permanganate.7 Street names Street slang for methcathinone may include terms such as Cat, Jeff, Bathtub Speed, Wannabe-Speed, Kitty, Meth's Cat, or Meth's Kitten. In Europe, methcathinone is primarily known as Ephedrone. In Australia, methcathinone may be known as ketone or bk beta ketone. In South Africa it is primarily known as CAT or occasionally KAT. There, it is also confused via name alone, not presentation with Khat sometimes spelled Qat. Another confusing name is that given to Tik - the local name for methamphetamine. Addiction In preclinical studies, methcathinone hydrochloride produces an abuse potential similar to that of the amphetamines. Methcathinone can be highly psychologically addictive, and can produce methamphetamine-like withdrawals, which is somewhat less in intensity than methamphetamine. It is highly unlikely for a methcathinone user to experience addiction on their first or even several subsequent administrations of the drug. In drug discrimination studies, methcathinone hydrochloride evokes responses similar to those induced by both +-amphetamine sulfate and cocaine hydrochloride. When examined in particular pharmacological assays for psychomotor stimulant-like activity, both the d and l enantiomeric forms of methcathinone hydrochloride have been found to be pharmacologically active. In these assays, the l-form of methcathinone is more active than either d-methcathinone or +-amphetamine. Racemic methcathinone hydrochloride is intravenously self-administered by baboons, thus indicating that methcathinone produces reinforcing effects in this laboratory animal, and suggesting that the drug has a potential for abuse in the human population. Clinical use In the US, methcathinone is listed as a Schedule I drug, for which there is no clinical use. Research in the United States without a specific DEA permit is also prohibited. In the Netherlands, methylcathinone is listed as a Level I substance of the Opium Law, for which there is no clinical use. In the UK, methcathinone is listed as a Class B drug,8 with no clinical uses. Furthermore, anecdotal reports from USENET posts in the 1990s indicate that unlike many stimulants, methcathinone doesn't have the inhibitory effects seen in other stimulants that make them useful as medications to treat Attention Deficit Hyperactivity Disorder. See also Other related phenethylamine drugs and plants: Khat contains cathinone and cathine Methamphetamine Phenethylamine Ephedrine Pseudoephedrine Phenylpropanolamine Other CNS-active phenyl-ethylamino ketones Drugs that contain the cathinone core structure: Diethylcathinone Tenuate Ethcathinone Dimethylcathinone Bupropion Wellbutrin, Zyban Methylone Methedrone Mephedrone External links Cathinone Methcathinone from Erowid Methcathinone from lycaeum References ^ Calkins RF, Aktan GB, Hussain KL. Methcathinone: the next illicit stimulant epidemic? J Psychoactive Drugs. 1995 Jul-Sep;273:277-85. PMID 8594170 ^ Erowid ^ a b Methcathinone HCl FAQ v2.2 ^ http://designer-drugs.com/pte/12.162.180.114/dcd/chemistry/methcathinone.txt ^ a b Glennon RA, Yousif M, Naiman N, Kalix P 1987. Methcathinone: a new and potent amphetamine-like agent. Pharmacol. Biochem. Behav. 26 3: 547-51. doi:10.1016/0091-30578790164-X. PMID 3575369. ^ Rothman, B. R. et al June 2003. In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates. The Journal of Pharmacology and Experimental Theraputics 307 1. ^ de Bie RM, Gladstone RM, Strafella AP, Ko JH, Lang AE. Manganese-induced Parkinsonism associated with methcathinone Ephedrone abuse. Archives of Neurology. 2007 Jun;646:886-9 PMID 17562938 ^ The Misuse of Drugs Act 1971 Modification Order 1998 SI 1998 No. 750. Statutory Instrument. Ministry of Justice 1998-03-18. Retrieved on 2008-07-06. International Drug Scheduling; Convention on Psychotropic Substances; Certain Stimulant/Hallucinogenic Drugs and Certain Nonbarbiturate Sedative Drugs, Food and Drug Administration, June 20, 1994. v d e Phenethylamines 2C-B 2C-C 2C-D 2C-E 2C-I 2C-N 2C-T-2 2C-T-21 2C-T-4 2C-T-7 2C-T-8 3C-E 4-FMP Bupropion Cathine Cathinone Clenbuterol DESOXY Dextroamphetamine Methamphetamine Diethylcathinone Dimethylcathinone DOC DOB DOI DOM bk-MBDB Dopamine Br-DFLY Ephedrine Epinephrine Escaline Etafedrine Fenfluramine Levosalbutamol Levmetamfetamine MBDB MDA MDMA MDMC MDEA MDPV Mescaline Methcathinone Norepinephrine Phentermine Salbutamol Tyramine Venlafaxine Retrieved from http://en..org/wiki/Methcathinone Categories: Alkaloids | Amphetamines | Class A drugs | Class B drugs | StimulantsHidden categories: Articles needing additional references from July 2007 | All articles with statements | Articles with statements since April 2007 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Français 日本語 Polski This page was last modified on 23 July 2008, at 15:30
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie video
The Power of You video
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.