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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 09:55:57 - Niaprazine Niaprazine Systematic IUPAC name N-4-4-4-fluorophenylpiperazin-1-ylbutan-2-ylpyridine-3-carboxamide Identifiers CAS number 27367-90-4 ATC code N05CM16 PubChem 71919 Chemical data Formula C20H25FN4O Mol. mass 356.437 Pharmacokinetic data Bioavailability ? Metabolism ? Half life 4.53 hours ± 0.86 Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status ℞-onlyUS Routes Oral Niaprazine Nopron is a piperazine derivative drug which acts as a sedating antihistamine. It was invented in the 1970s 1, and is used in France, Italy and other European countries. It is mainly prescribed for its relatively strong sedative effects rather than as an antihistamine, and is used mainly for treating autism 2 and insomnia 3 in children and adolescents. Side effects Common side effects are: sedation during the day especially during the first few days of treatment and dizziness. Less common side effect is headache during the day. Method of Action Niaprazine is a potent antagonist of the Histamine H1 receptor and is also an agonist at the serotonin receptors 5HT1A, 5HT2A and 5HT2C via its metabolite pFPP. Niaprazine enhances slow wave sleep.4 References ^ Duchene-Marullaz P, Rispat G, Perriere JP, Hache J, Labrid C. Some pharmacodynamical properties of niaprazine, a new antihistaminic agent. French Therapie. 1971 Nov-Dec;266:1203-9. ^ Rossi PG, Posar A, Parmeggiani A, Pipitone E, D'Agata M. Niaprazine in the treatment of autistic disorder. Journal of Child Neurology. 1999 Aug;148:547-50. ^ Younus M, Labellarte MJ. Insomnia in children: when are hypnotics indicated? Paediatric Drugs. 2002;46:391-403. ^ ZUCCONI et al. 1988, KALES: The pharmacology of sleep, 1995 v d e Psycholeptics: hypnotics and sedatives N05C GABAA receptor Barbiturates Allobarbital - Amobarbital - Aprobarbital - Barbital - Butobarbital - Cyclobarbital - Ethallobarbital - Heptabarbital - Hexobarbital - Methohexital - Pentobarbital - Phenobarbital - Proxibarbal - Reposal - Secobarbital - Talbutal - Thiopental - Vinylbital - Vinbarbital Benzodiazepines Brotizolam - Cinolazepam - Doxefazepam - Estazolam - Flunitrazepam - Flurazepam - Flutoprazepam - Loprazolam - Lormetazepam - Nitrazepam - Nimetazepam - Midazolam - Quazepam - Temazepam - Triazolam Nonbenzodiazepines CL-218,872 - Eszopiclone - Indiplon - Necopidem - Pazinaclone - ROD-188 - Saripidem - Suproclone - Suriclone - SX-3228 - U-89843A - U-90042 - Zaleplon - Zolpidem - Zopiclone Piperidinediones Glutethimide - Methyprylon - Pyrithyldione Quinazolinones Afloqualone - Cloroqualone - Diproqualone - Etaqualone - Mebroqualone - Mecloqualone - Methaqualone - Methylmethaqualone Neuroactive steroids Acebrochol - Allopregnanolone - Alphadolone - Alphaxolone - Ganaxolone - Hydroxydione - Minaxolone - Org 20599 - Tetrahydrodeoxycorticosterone Alpha-2 adrenergic receptor Alpha-adrenergic agonist 4-NEMD - Clonidine - Dexmedetomidine - Lofexidine - Medetomidine - Romifidine - Tizanidine - Xylazine Melatonin receptor Melatonin Agomelatine - Melatonin - Ramelteon Histamine receptor Acetylcholine receptor Antihistamines Anticholinergics Doxylamine - Hydroxyzine - Diphenhydramine - Bromodiphenhydramine - Carbinoxamine - Orphenadrine - Niaprazine - Phenyltoloxamine - Propiomazine - Pyrilamine - Scopolamine GABAB receptor / GHB receptor GHB Type Aceburic acid - GABOB - GHB Sodium Oxybate, Xyrem® - GBL - 1,4-Butanediol - 3-Chloropropanoic acid Other receptors/ ungrouped Aldehydes Acetylglycinamide chloral hydrate - Chloral hydrate - Chloralodol - Dichloralphenazone - Paraldehyde - Petrichloral Alkynes Centalun - Ethchlorvynol - Ethinamate - Hexapropymate - Methylpentynol Carbamates Meprobamate - Carisoprodol - Tybamate - Methocarbamol Other 2-Methyl-2-butanol - Acecarbromal - Apronal - Bromides - Bromisoval - Carbromal - Clomethiazole - Embutramide - Etomidate - Gaboxadol - Loreclezole - Mephenoxalone - Sulfonmethane - Trichloroethanol - Triclofos - Valerian - Valnoctamide - Trazadone v d e Histamine antagonists H1 or non-selective Alkylamines Bepotastine Bamipine Brompheniramine Chlorpheniramine Dexbrompheniramine Dexchlorpheniramine Dimethindene Metron S Pheniramine Pyrrobutamine Talastine Thenaldine Tolpropamine Triprolidine Ethanolamines Aminoalkyl ethers Bietanautine Bromazine/Bromodiphenhydramine Carbinoxamine Chlorphenoxamine Clemastine Diphenylpyraline Diphenhydramine Doxylamine Embramine p-Methyldiphenhydramine Moxastine Orphenadrine Phenyltoloxamine Setastine Ethylenediamines Chloropyramine Chlorothen Histapyrrodine Methafurylene Mepyramine Methapyrilene Pyrilamine Talastine Thenyldiamine Thonzylamine Tripelennamine Pyribenzamine Phenothiazine Tricyclics Ahistan Etymemazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Thiazinamium Other Tricyclics Azatadine Clobenzepam Cyproheptadine Deptropine Isothipendyl Loratidine Piperazine Buclizine Chlorcyclizine Cinnarizine Clocinizine Hydroxyzine Niaprazine Oxatomide Benzhydryl compounds Cyclizine, Meclizine Others including selective, 2nd gen, 3rd gen Antazoline Astemizole Azatadine Azelastine Bepottastine Bamipine Cetoxine Clemizole Clobenztropine Deptropine Desloratadine Dimebon Ebastine Emedastine Epinastine Ketotifen Levocabastine Loratadine Mebhydrolin Mizolastine Phenindamine Pimethixene Pyrrobutamine Rupatadine Thenalidine Tritoqualine Alkylamine Acrivastine Tricyclic Olopatadine Piperazine Levocetirizine, Cetirizine Benzhydryl compounds Fexofenadine, Terfenadine H2 Cimetidine Famotidine Ranitidine Roxatidine Lafutidine Niperotidine Nizatidine H3 A-349,821 ABT-239 Burimamide Ciproxifan Clobenpropit Conessine Impentamine Iodophenpropit Thioperamide VUF-5681 H4 JNJ 7777120 Thioperamide VUF-6002 Retrieved from http://en..org/wiki/Niaprazine Categories: Piperazines Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 5 May 2008, at 04:26
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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