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20-September-2008 09:55:56 - Nootropic Nootropics, popularly referred to as smart drugs, smart nutrients, cognitive enhancers and brain enhancers, are a class of drugs that improve impaired human cognitive abilities the functions and capacities of the brain.1 The term covers a broad range of substances including drugs, nutrients and herbs that have purported cognitive enhancing effects. The word nootropic was coined in 1964 by the Romanian Dr. Corneliu E. Giurgea, derived from the Greek words noos, or mind, and tropein meaning to bend/turn. Typically, nootropics are alleged to work by altering the availability of the brain's supply of neurochemicals neurotransmitters, enzymes, and hormones, by improving the brain's oxygen supply, or by stimulating nerve growth. However the efficacy of alleged nootropic substances in most cases has not been conclusively determined. This is complicated by the difficulty of defining and quantifying cognition and intelligence. Contents 1 Availability 2 Therapy or enhancement 3 Examples 3.1 Replenishing and increasing neurotransmitters 3.1.1 Cholinergics 3.1.1.1 Piracetam 3.1.1.2 Aniracetam 3.1.1.3 Other cholinergics 3.1.1.4 Acetylcholinesterase inhibitors 3.1.2 Dopaminergics 3.1.3 Serotonergics 3.2 Anti-depression, adaptogenic antistress, and mood stabilization 3.3 Brain function and improved oxygen supply 3.4 Mental agility, concentration, stamina, and focus 3.5 Purported memory enhancement and learning improvement 3.6 Nerve growth stimulation and brain cell protection 3.7 Recreational drugs with purported nootropic effects 3.8 Dietary nootropics 3.9 Other nootropics 3.9.1 Contentious or possibly unsafe nootropics 4 See also 4.1 Brain and neurology 4.2 Thought and thinking what nootropics are used for 4.3 Health 5 References 6 External links Availability The drugs are used to treat people with cognitive learning difficulties, neural degradation Alzheimer's disease or Parkinson's disease, and for cases of oxygen deficit to prevent hypoxia. These drugs have a variety of human enhancement applications as well and are marketed heavily on the World Wide Web. Nevertheless, intense marketing may not correlate with efficacy; while scientific studies support some of the claimed benefits, it is worth noting that many of the claims attributed to most nootropics have not been formally tested. Therapy or enhancement Some argue that nootropics may theoretically be used for human enhancement, boosting mental function in otherwise normal healthy people. However, there is much controversy over the legitimacy efficacy and ethics of such applications. This may contribute to the lack of research on such effects. Examples The term drug here is used as a legal designation, and does not indicate greater efficacy. With nootropics, the effects, effectiveness, and potency differ from substance to substance and from individual to individual. See the substance descriptions below for more detail. Replenishing and increasing neurotransmitters As the brain ages, its ability to produce and maintain youthful levels of neurotransmitters declines.2 There are various reasons for such an insufficiency. For instance, there might be a lack of enzymes involved in the neurotransmitter synthesis. Nevertheless, in many cases, providing the brain with ample raw materials necessary to make neurotransmitters can restore them to more youthful levels and thus help maintain cognitive function at vigorous youthful levels.citation needed Furthermore, there are declines in immune and endocrine functioning. 3 Certain nootropics enhance immune and endocrine functioning. Cholinergics Cholinergics are substances that affect the neurotransmitter acetylcholine or the components of the nervous system that use acetylcholine. Acetylcholine facilitates memory, concentration, focus, and high-order thought processes abstract thought, calculation, innovation, etc..citation needed Increasing the availability of this neurotransmitter in the brain may improve these functions and increase the duration in which they may be engaged without slowing down or stopping. Oversupplying the brain with acetylcholine may have the opposite effect, temporarily reducing rather than improving mental performance.citation needed Cholinergic nootropics include acetylcholine precursors and cofactors, and acetylcholinesterase inhibitors: Piracetam Main article: Piracetam Piracetam Nootropil is a prescription drug in Europe. It is the original4 and most commonly taken54 nootropic drug. It is a cholinergic agent synergistic with DMAE, Centrophenoxine, choline, Alpha-GPC and Hydergine. It increases brain cell metabolism and energy levels,64 and speeds up interhemispheric flow of information left-right brain hemisphere communication. It increases alertness,7 improves concentration, and enhances memory. Protects neurons from hypoxia,4 and stimulates growth of acetylcholine receptors.citation needed May also cause nerves to regenerate.citation needed Piracetam markedly decreases the formation of neuronal lipofuscin.8 It improves posture in elderly people.9 It is not regulated in the US.citation needed It is a pyrrolidone derivative. Aniracetam Main article: Aniracetam Aniracetam is a pyrrolidone derivative drug, analogous of piracetam, and considered more potentcitation needed. Like piracetam, aniracetam protects against some memory impairing chemicals, such as diethyldithiocarbamate and clonidine.10 Also like piracetam, aniracetam may enhance memory in aging adults by increasing levels of brain biogenic monoamines, which are beneficial to learning and memory.2 Both racetams have possible therapeutic use in treating fetal alcohol syndrome.11 Aniracetam increases vigilance7. Aniracetam has shown to positively potentiate AMPA receptors. Other cholinergics This section needs additional citations for verification. December 2007 Acetyl-L-carnitine ALCAR - Amino acid. Precursor of acetylcholine donating the acetyl portion to the acetylcholine molecule. It is synergistic with lipoic acid.12 Inhibits lipofuscin formation. Choline - precursor to acetylcholine an essential component of the acetylcholine molecule. Alpha-GPC L-alpha glycerylphosphorylcholine, Choline alfoscerate - most effective choline precursor, readily crosses the blood-brain barrier. Citicoline - less expensive and similar in effect to Alpha GPC. Appears effective in rats.1314 Choline bitartrate - precursor of acetylcholine, anti-depressant. Choline citrate - precursor of the neurotransmitter acetylcholine, anti-depressant.citation needed DMAE - approved treatment for ADD/ADHDcitation needed, precursor of acetylcholine, cholinergic agent, removes lipofuscin from the brain, anti-depressant. Galantamine - acetylcholinesterase inhibitor made from chemical synthesis or extract from plants such as Red Spider Lily Lycoris radiata. Huperzine A - potent acetylcholinesterase inhibitor derived from Chinese club-moss. Recent Cochrane review concluded that it appears to have beneficial cognitive effects with limited side-effects, but more evidence is needed.15 Ispronicline - recently developed selective α4β2 partial agonist Lecithin - contains phosphatidylcholine, precursor of acetylcholine. Other pyrrolidone derivatives: Etiracetam - It increases vigilance.7 Nefiracetam - Drug. Analog of piracetam, and facilitates hippocampal neurotransmission.16 Oxiracetam - Drug. Analog of piracetam, and 2 to 4 times stronger. Improves memory, concentration, and vigilance. When fed to pregnant rats, the offspring of those rats were more intelligent than the offspring of rats fed a saline solution placebo. Pramiracetam - Drug. Analog of piracetam. In animal studies, nootropics such as piracetam, oxiracetam and aniracetam are known to facilitate the formation of long term memory traces and to restore object recognition in aging rats. 17 There is evidence that the beneficial effect of racetams may result from an interaction with the central glutamatergic receptor function. 17 Vitamin B5 - cofactor in the conversion of choline into acetylcholine, cholinergic agent, increases stamina including mental stamina. Excess acetylcholine is considered by many to be potentially harmful; see acetylcholinesterase inhibitor. Acetylcholinesterase inhibitors Acetylcholinesterase inhibitors function by inhibiting the cholinesterase enzyme which breaks down the neurotransmitter acetylcholine. They exist in the form of poisons and have been used as weapons, but they are also used to treat Alzheimer's patients. Donepezil, galantamine, and Huperzine A are notable among these. Dopaminergics Dopaminergics are substances that affect the neurotransmitter dopamine or the components of the nervous system that use dopamine. Dopamine is produced in the synthesis of all catecholamine neurotransmitters, and is the rate limiting step for this synthesis. Dopaminergic nootropics include dopamine precursors and cofactors vitamin C and vitamin B6, and dopamine reuptake inhibitors: Mucuna pruriens - Seed powder which contains high concentrations of levodopa L-dopa,18 a direct precursor of the neurotransmitter dopamine. Tyrosine requires Vitamin B6 and Vitamin C - Amino acid. Precursor to dopamine, anti-depressant, sleep reducer. Lazabemide - a MAO-B inhibitor and has potent membrane lipid antioxidant activity. The antioxidant effects of lazabemide are attributed to its chemical structure and direct physicochemical interactions with the membrane lipid bilayer. It is a potent antioxidant, even more powerful than selegiline deprenyl or vitamin E, and is used to treat Alzheimer's disease.19 L-dopa - Prescription drug and dietary supplement. Precursor to the neurotransmitter dopamine, anti-depressant. Phenylalanine requires Vitamin B6 and Vitamin C - Essential amino acid. Precursor to dopamine, anti-depressant, sleep reducer. Selegiline - L-deprenyl is an irreversible MAO-B inhibitor, an enzyme that breaks down dopamine. Thus, it is used to treat Parkinson's disease, and has been tested as a treatment for Alzheimer's disease.20 It protects against the genotoxin AraC, provides neuroprotection against growth factor withdrawal in PC12 cells, protects against oxidative stress in mesencephalatic neurons, and delays neuronal cell death in the hippocampus after global ischemia.21 Tolcapone - Inhibits COMT an enzyme that breaks down the neurotransmitters dopamine, epinephrine, and norepinephrine and increases performance in tasks depending on working memory in individuals with the val/val and val/met genotype of the val158Met polymorphism of the catechol-O-methyltransferase gene, while decreasing it in presence of the met/met version. Tolcapone presents the risk of deadly side effects. Yohimbe - Bark. Aphrodisiac. Boosts dopamine levels,citation needed though how it does this is not yet understood. Supplements are likely to have no yohimbe in them.22 Yohimbe poses some health risks through its side-effects: it is a neuro-paralytic which slows down breathing and induces acidosis, some symptoms of which are malaise, nausea, and vomiting. Contraindicated for users of megadoses of acidic vitamins or nutrients. Theanine - Found in tea. Increases serotonin and dopamine levels in the brain. Increases alpha-wave based alert relaxation. Serotonergics This section does not cite any references or sources. Please help improve this section by adding citations to reliable sources. December 2007 Serotonergics are substances that affect the neurotransmitter serotonin or the components of the nervous system that use serotonin. Serotonergic nootropics include serotonin precursors and cofactors, and serotonin reuptake inhibitors: Griffonia simplicifolia a natural source of 5-HTP an alternative in countries where 5-HTP not legal, freely available. Tryptophan requires Vitamin B6 and Vitamin C - Essential amino acid. Precursor to serotonin, found in high concentration in bananas and meats, also in milk, promotes relaxed poise and sound sleep. 5-HTP is chemically related to tryptophan. 5HT2A agonists such as LSD and 2C-T-7 have been shown to produce nootropic effects when used at a dose much lower than a hallucinogenic dose. e.g. 10 μg for LSD and 1 mg 2C-T-7, 1/25 of a normal recreational dose citation needed SSRIs - Class of antidepressants that increase active serotonin levels, ie, in the synaptic junction, by inhibiting its reuptake. Have also been shown to promote Neurogenesis in the hippocampus. Anti-depression, adaptogenic antistress, and mood stabilization This section does not cite any references or sources. Please help improve this section by adding citations to reliable sources. January 2008 Stress, depression, and depressed mood negatively affect cognitive performance. It is reasoned that counteracting and preventing depression and stress may be an effective nootropic strategy. Below are a list of substances purported to function as nootropics, and claimed effects: Ashwagandha Withania somnifera - Root. Also known as Indian ginseng. Adaptogen used as a tonic to normalize body processes and reduce stress and anxiety. Inositol - Is a B-vitamin like substance with anti-anxiety effects. It is believed to produce its anti-anxiety effects by improving the binding of gabaergics to GABAA receptors. Inositol is a sugar, and is therefore an alternative energy source for brain and muscle tissues. It produces a sugar high without a sugar low, making it especially suited for sweetening tea instead of sugar. It is also a membrane stabilizer which can strengthen and therefore help protect neurons. Kava kava - The roots of the Kava-Kava plant contain Kavalactones which have GABAergic properties and are used to combat anxiety.23 Lemon Balm Melissa officinalis - Herb. Anti-depressant. Passion Flower is used to treat depression. It is commonly combined with St. John's Wort and Valerian, which work synergistically to reestablish the patients emotional balance without causing tachyphylaxia, hangovers, or addiction. 23 Rhodiola Rosea - Herb. Adaptogen; elevates mood, alleviates depression. Promotes mental energy and stamina, reduces fatigue. Boosts dopamine. Slows breakdown of serotonin. St John's Wort - Herb. The active components: hypericin and hyperforin, are clinically indicated to be effective in cases of mild to moderate depression, on par with synthetic drugs. However, St John's Wort is not suitable for the treatment of severe depression or suicidal tendencies. Side effects include gastrointestinal complaints and allergic reactions such as pruritus and phototoxicity. 23 Ginseng, Siberian Eleutherococcus senticosus - Root. Anti-anxiety adaptogen that normalizes physical stress and mental consequences. Selegiline Deprenyl - Along with Piracetam and Meclofenoxate, Deprenyl decreases the amount of lipofuscin pigment and ceroid pigment accumulations in the brain by improving cellular recycling activities.24 Therefore, these nootropics may slow age-related diseases in the brain. Selegiline, an MAO-B inhibitor, is used as an antioxidant for the treatment of Alzheimer's disease. 19 Sutherlandia frutescens - Herb. Adaptogen, blood detoxifier. Tea - Herb. Contains theophylline and theanine. Increases alpha-wave based alert relaxation relieves stress. Theanine - Amino acid. Found in tea. Increases serotonin and dopamine levels in the brain. Increases alpha-wave based alert relaxation. Also stimulates the GABAergic system. Tianeptine - Anxiolytic anti-depressant. It enhances working and reference memory in rats.25 Vasopressin - Drug. Memory hormone produced by the pituitary gland which improves both memory encoding and recall. Rapidly counters chronic apathy syndrome and drug-induced vasopressin depletion. Vasodilator - Mood stabilizer, with a powerful anti-anxiety effect - perhaps the best and most immediate stress reliever available note that other forms of vitamin B do not have this effect. Side effects: gastric upset which is easily prevented and relieved with antacids, reduced blood pressure and flushing of the skin caused by vasodilation, and itchy sensation in the skin caused by histamine release. Vitis vinifera Grape Seed Grape seed has antistress adaptogenic activity, protects against memory loss induced by scopolamine, is an antioxidant, has nootropic activities, and supports the traditional claims for the use of grape fruits and seeds in stress induced disorders. 26 Brain function and improved oxygen supply This section does not cite any references or sources. Please help improve this section by adding citations to reliable sources. December 2007 Chromium- stabilises blood sugar levels promoting concentration. Coenzyme q-10 syn. Ubiquinone - increases oxygen transport through the mitochondria of the cells. Creatine - increases brain energy levels via ATP production. Inositol - B vitamin which synergizes with other nootropics Lipoic acid - synergistic with Acetyl-L-carnitine. Pyritinol Enerbol - Drug. Enhances oxygen and glucose uptake in the brain, and allows glucose to pass more easily through the blood-brain barrier. It is also a powerful anti-oxidant which scavenges hydroxyl radicals created in the very processes it is involved in. Vinpocetine - Vinpocetine increases blood circulation and metabolism in the brain. Animal studies have shown that vinpocetine can reduce the loss of neurons due to decreased blood flow. 4 Prazosin - Alpha-blocking blood pressure medication also prescribed as an anti-PTSD medication, appears to block the increase of steroid hormones known as glucocorticoids, Oregon Health Science University and Portland Veterans Affairs Medical Center researchers have found. Elevated levels of glucocorticoids are associated with atrophy in nerve branches where impulses are transmitted, and even nerve cell death, in the hippocampus. Mental agility, concentration, stamina, and focus This section needs additional citations for verification. January 2008 Adrafinil Olmifon - Drug. Caffeine - Drug. Improves concentration, idea production, but hinders memory encoding. Large amounts produce the jitters. Caffeine is the most widely used psychoactive substance in the world, and may be susceptible to strong levels of tolerance. Coffee - Bean. Contains caffeine; brewed coffee is high in antioxidants. Nicergoline - Drug. Nicergoline is an ergoloid mesylate derivative used to treat senile dementia. It has also been found to increase mental agility and enhance clarity and perception. It increases vigilance.7 Increases arterial flow and use of oxygen and glucose in the brain. Nicotine - stimulus barrier aids in concentration. Stimulus barrier rebound effect an unpleasant side effect. Cocaine - Drug. Methylphenidate Ritalin - Drug Dextroamphetamine - Adderall, Dexedrine - Drug. Modafinil - Provigil - Drug. Phenibut - Theophylline - Amphetamine - aids in concentration, focus and stamina. Prescribed for ADD/ADHD Carphedon Phenotropil - Purported memory enhancement and learning improvement This section needs additional citations for verification. December 2007 All of the nergics listed above are purported to improve memory encoding and recall, as do all nootropics which improve general brain performance in categories such as the brain energy and oxygen supply, and nerve growth stimulation and protection. Other agents purported to have these specific benefits are mentioned in their own sections. Other nootropics with specific effects on memory encoding and recall include: Bacopa monniera Brahmi - Herb. Elevates curiosity, enhances memory and concentration.27 Brahmi also protects against amnesia inducing chemicals such as scopolamine or loss of memory due to electro convulsive shocks.27 Improves protein synthesis in brain cell repair and new dendritic growth. It is a traditional ayurvedic medicine. Brahmi rasayana - improved learning and memory in mice.28 Rosemary - Herb. Rosemary has a very old, albeit unverified, reputation for improving memory. Vasopressin - Hormone, prescription drug. Dextroamphetamine- Adderall, Dexedrine.29 Nicotine - Improves working memory and learning30 Sage - a study of young adults found that Salvia lavandulaefolia improves word recall;31 a randomized trial has found that Salvia officinalis improves symptoms in Alzheimer's patients32 Nerve growth stimulation and brain cell protection This section needs additional citations for verification. December 2007 Ergoloid mesylates Hydergine - Drug. Mimics nerve growth factor NGF, and is a powerful anti-oxidant capable of delaying brain death in cases of heart failure and stroke by several minutes with regular use. It increases vigilance.7 Idebenone - stimulates nerve growth, and has same effects as Coenzyme q-10. Inositol - Membrane stabilizer. Strengthens neurons, making them less susceptible to damage. Pyritinol Enerbol - Drug. Powerful anti-oxidant which scavenges hydroxyl radicals. Rasagiline Azilect - Drug. Treats Parkinson's disease either as monotherapy by itself or in addition to levodopa therapy. Promotes increased and sustained levels of dopamine by selectively inhibiting an enzyme, monoamine oxidase-B. Recreational drugs with purported nootropic effects See also: Controlled substances act and Misuse of Drugs Act 1971 Amphetamine-type stimulants such as Adderall, Dexedrine, Desoxyn, etc. are Schedule II controlled substances in the United States, and Class B drugs in the United Kingdom, with comparable legal controls in effect in most countries throughout the world. They are prescribed for attention-deficit disorders, narcolepsy, and certain cases of obesity; and are issued to counteract fatigue and to enhance performance for pilots in the armed forces of the United States of America.3334 These also heighten alertness, mental focus, vigilance, stamina, and sex drive. They tend to be habit-forming, and exhibit side effects with prolonged or heavy use. Personal importation of amphetamine-class drugs is prohibited in many countries, and their use for recreation or for performance enhancement without a medical prescription is likewise illegal in most countries. LSD - Schedule I / Class A drug. At higher doses, the impact of the senses on one's mind are expanded to such an overwhelming degree that what is being sensed seems qualitatively different. Many psychedelic drugs are known to produce this overwhelming effect on the mind. Aldous Huxley called this state of mind Mind at Large. Activity in the Raphe Nuclei and Locus ceruleus increases dramatically following administration of LSD to produce extremely heightened creativity in many users. This effect on the creative process is a phenomenon that may be due to ascending traffic in the reticular activation system, which can result in stimulus overload. The longest single research project with LSD, at Spring Grove Hospital, Maryland, showed an average 10% increase in linear IQ alone.35 Also produces hallucinogenic and entheogenic effects at doses as low as 30-40 μg micrograms, with the likelihood of having a bad trip increasing as dose is increased if these effects are undesired. May also cause cognitive shifts, and synesthesia The drug sometimes spurs long-term or even permanent changes in a user's personality and life perspective. For more details, see Albert Hofmann: LSD - My Problem Child. 4-methylaminorex Pemoline Cylert Psilocybin and Psilocin MDPV Mescaline 2C-D Dietary nootropics Some regular food items are rich sources of substances with alleged nootropic benefits: Nuts, in particular walnuts, are rich sources of alpha-linolenic acid ALA, a type of omega-3 fatty acid. A mixture of walnuts served with dried fruit pieces is known in some regions as student food orig. German: Studentenfutter and is popularly recommended as a snack for students. Oily fish, such as salmon or fresh tuna not tuna canned in oil are also good sources of omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid, whose lack in diet has been associated with increased risk of mental illnesses such as depression, anxiety, aggressive behavior, schizophrenia, or hyper-activity in children see omega-3 fatty acids article Other nootropics This section needs additional citations for verification. December 2007 Adafenoxate - Has an anti-anxiety effect for rats36 and possibly the same for humans. Moderate use of alcohol - Moderate drinking has been associated with better cognitive ability than both abstention and heavy drinking.3738394041 Butea frondosa - The plant Butea frondosa has been indicated in the Indian system of medicine as a plant augmenting memory and as a rejuvenator. ... B. frondosa possesses anti-stress and weak nootropic activity.42 BMY 21502 - Injured animals treated with BMY-21502 at one week post-injury showed significant improvement in post-injury learning ability compared to injured animals treated with vehicle. Paradoxically, in uninjured control animals BMY-21502 treatment appeared to worsen learning scores. The results of this study indicate that BMY-21502 may be useful for attenuating the dysfunction in learning ability that occurs following traumatic brain injury. Cabergoline Dostinex - A lysergic acid amide derivative, is a potent dopamine receptor agonist on D2 receptors. Maybe carcinogenic. Celastrus paniculatus - Oil made from the seeds of this shrub are used in Ayurvedice medicine to increase memory and facilitate learning. It allegedly induces a feeling of well-being and has reported aphrodisiac effects. Cerebrolysin - A neuroprotective nootropic agent, might affect Alzheimer's disease pathology. Currently in clinical trialscitation needed Clausenamide - Facilitated learning and memory acquisition in step down and step through tests and increased thickness of cerebral cortex and synapse density significantly in the dentate cells over pyramidel cells in hippocampal region in mice. Coluracetam - It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injurycitation needed Desmopressin DDAVP - Analog of vasopressin, a neuropeptide responsible for memory. DHEA - Hormone created by the adrenal glands; Precursor to Estrogen and Testosterone Dostinex - see Cabergoline above Fasoracetam - A nootropic drug of the racetam family. Essential Fatty Acids- Eicosapentaenoic acid EPA and docosahexaenoic acid DHA are the best known. EPA in particular, has an anti-depressant function and is positively indicated in trials with autism and learning difficultiescitation needed Fipexide Vigilor - It protects against some memory impairing chemicals, such as diethyldithiocarbamate and clonidine.10 Gerovital H3 - Romanian anti-aging formula containing procaine hydrochloride, but which breaks down into PABA and DMAE. Gotu Kola - Herb and root. Meclofenoxate - Has an anti-anxiety effect for rats36 and possibly the same for humans. Like Fipexide, it protects against some memory impairing chemicals, such as diethyldithiocarbamate and clonidine.10 Like many racetams, it may treat fetal alcohol syndrome.11 Milacemide - A glycine prodrug which is both an inhibitor and a substrate for monoamine oxidase-type B MAO-B and also an inhibitor of MAO-type A MAO-A. Nimodipine - A dihydropyridine calcium channel blocker originally developed for the treatment of high blood pressure. Ondansetron Zofran - A serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy. Phenytoin Dilantin - A neuroleptic and anti-seizure medication advocated by Jack Dreyfus for a variety of psychological conditions. Phosphatidylserine- In animals, PS has been shown to attenuate many neuronal effects of aging, and to restore normal memory on a variety of tasks. 4 Picamilon or Pikamilone - Compound of Niacin and GABA. It can pass the blood-brain barrier and increase amount of GABA in the brain.citation needed Pregnenolone - Hormone; Precursor to DHEA; Pyroglutamate - An amino acid shown to improve learning. Sapunifiram Semax - A neuropeptide stimulator of the nervous system developed from a short fragment of ACTH, Pro8-Gly9-Pro10 ACTH4-10. Claims of significant increase in salvation of neurons are madecitation needed Somatotropin - Growth hormone, a polypeptide containing 191 amino acids, produced by the anterior pituitary, the front section of the pituitary gland. It acts by stimulating the release of another hormone called somatomedin by the liver, thereby causing growth. Sulbutiamine Arcalion - Drug - derivative of thiamine vitamin B1 that can cross the blood-brain barrier and work as anti-fatigue and cognitive support agent.citation needed Sunifiram Turmeric - has possible benefits in Alzheimer's disease, cancer and liver disorders. Turmeric, under the name Avea, is becoming popular to treat depression. Unifiram Xanthinol Nicotinate Complamin - A drug that has been shown to stimulate memory and concentration, by improving blood flow to the brain. MDL 26,47943 Propentofylline Contentious or possibly unsafe nootropics Royal Jelly - Produced by bees for the Queen. Can cause fatal allergic reactions if allergic to bee products. Shown to dramatically increase nerve stem cell growth and differentiation of mice nerve cells - in vitro petri dish.citation needed Ginkgo biloba - Patients with dementia treated with Ginkgo showed significant improvement of symptoms like memory loss, concentration difficulties, fatigue, anxiety and depressive mood. 23 As a vasodilator, it should not be taken with aspirin, for doing so could increase the risk of bleeding.44 Ginkgo is widely used in Europe to treat subjective tinnitus, although there is as yet no hard evidence supporting this assertion. 44 Ginkgolides are extracts from the leaves of the tree. They produce a beneficial effect for Alzheimer's disease, and for amyloid-B, the toxic prion protein, which suggests they could be relevant to treating those diseases.45 Arecoline See also Brain and neurology Action potential Aging and memory Brain Central nervous system CNS Dendrite Human brain Long-term potentiation Nervous system Neurite Neuron Neuroplasticity Neuroscience Neurotransmitter Sensory neuroscience Synapse Synaptic plasticity List of nootropics smart drugs Thought and thinking what nootropics are used for Abstract thinking Attention Attitude Brainstorming Cognition Cognitive science Creative thinking Critical thinking Curiosity Decision Decision making Eidetic memory Emotions and feelings Emotional intelligence Goals and goal setting Idea Imagination Intelligence Introspection Lateral thinking Learning Memory Memory-prediction framework Mental calculation Mind's eye Mindset Mood Motivation Perception Personality Picture thinking Problem shaping Problem solving Reason Recollection recall Self-reflection Thought Visual thinking Health Anxiety Cognitive psychology Clinical depression Confusion Cosmetic pharmacology Drug Parasympathomimetics Prescription drug Prohibition drugs Psychoactive drug aka psychotropic drug Psychedelic drug Human enhancement Ergogenic aid Life extension Neurodegenerative disease Alzheimer's disease Parkinson's disease Nutrition Sleep disorders Stress Stress management References ^ n_10/12577719 at Dorland's Medical Dictionary ^ a b Stancheva, S.L., Petkov, V.D., Hadjiivanova, C.I., and Petkov, V.V. 1991. Age-related changes of the effects of a group of nootropic drugs on the content of rat brain biogenic monoamines. Gen. Pharmacol. Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia 22 5: 873-7. ^ Milton Hideaki Arai, Alberto JS Duarte, and Valeria Maria Natale, Disciplina de ClÃnica Geral do Hospital das ClÃnicas da Faculdade de Medicina da Universidade de São Paulo, Brazil 25 August 2006. The effects of long-term endurance training on the immune and endocrine systems of elderly men: the role of cytokines and anabolic hormones. Immunity Ageing 3 9. ^ a b c d e f McDaniel, M.A., Maier, S.F., and Einstein, G.O. 2002. Brain-Specific Nutrients: A Memory Cure?. Psychological Science in the Public Interest American Psychological Society 3 1. ^ Goldman, R., Klatz, R., and Berger, L. 1999. Brain fitness. New York: Doubleday. ^ Gabryel, B. and Trzeciak, H.I. 1994. Nootropics: Pharmacological properties and therapeutic use. Polish Journal of Pharmacology 46: 383-394. ^ a b c d e Saletu, B. and Grunberger, J. 1985. Memory dysfunction and vigilance: neurophysiological and psychopharmacological aspects. Annals of the New York Academy of Sciences 444 1: 406-27. doi:10.1111/j.1749-6632.1985.tb37604.x. PMID 3860093. ^ Paula-Barbosa, M.M., Brandao, F., Pinho, M.C., Andrade, J.P., Madeira, M.D., and Cadete-Leite, A. 1991-10-01. The effects of piracetam on lipofuscin of the rat cerebellar and hippocampal neurons after long-term alcohol treatment and withdrawal: a quantitative study. Alcohol Clin. Exp. Res. 15 5: 834-8. doi:10.1111/j.1530-0277.1991.tb00610.x. ^ Riedel, W.J., Peters, M.L., Van Boxtel, M.P.J., and O'Hanlon, J.F. 1998-12-04. The influence of piracetam on actual driving behaviour of elderly subjects. 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External links Society for the Advancement of Cosmetic Pharmacotherapy Business Week Online - I Can't Remember September 1, 2003 Slashdot Cognitive Enhancement Drugs HedWeb List of Nootropic drugs at Erowid.org List of Neurobiology Links Relevant to Nootropics v d e Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics N06B Centrally acting sympathomimetics Amphetamine - Amphetaminil - Atomoxetine - Dextroamphetamine - Dextromethamphetamine - Fencamfamin - Fenozolone - Fenetylline - Methylphenidate - Mesocarb - Pemoline - Pipradrol - Prolintane Xanthine derivatives Caffeine - Propentofylline Glutamate receptor Racetams Aniracetam - Nefiracetam - Oxiracetam - Phenylpiracetam - Piracetam - Pramiracetam Ampakines CX-516 - CX-546 - CX-614 - CX-691 - CX-717 - IDRA-21 - LY-503,430 - PEPA Eugeroics / Benzhydryl compounds Adrafinil - Armodafinil - Modafinil Histamine H3 receptor antagonists ABT-239 - Ciproxifan Other psychostimulants and nootropics Acetylcarnitine - Citicoline - Cyprodenate - Idebenone - Ispronicline - Deanol - Dimebon - Fipexide - Linopirdine - Meclofenoxate - Nizofenone - Pirisudanol - Pyritinol - Sulbutiamine - Taltirelin - Tricyanoaminopropene - Vinpocetine Retrieved from http://en..org/wiki/Nootropic Categories: NootropicsHidden categories: Pages with DOIs broken since 2008 | All articles with statements | Articles with statements since December 2007 | Articles with statements since July 2008 | Articles with statements since June 2008 | Articles with statements since February 2008 | Articles needing additional references from December 2007 | Articles with statements since November 2007 | Articles needing additional references from January 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages ÄŒesky Deutsch Español Français í•œêµì–´ Italiano 日本語 Polski Português РуÑ?Ñ?кий SlovenÄ?ina Suomi Svenska This page was last modified on 20 August 2008, at 16:45
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