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20-September-2008 09:55:54 - Basigin Redirected from OK antigen system Basigin Ok blood group Identifiers Symbols BSG; 5F7; CD147; EMMPRIN; M6; OK; TCSF External IDs OMIM: 109480 MGI: 88208 HomoloGene: 1308 Gene ontology Molecular function: signal transducer activity sugar binding mannose binding Cellular component: membrane integral to membrane Biological process: cell surface receptor linked signal transduction RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 682 12215 Ensembl ENSG00000172270 ENSMUSG00000023175 Uniprot P35613 O55107 Refseq NM_001728 mRNA NP_001719 protein NM_001077184 mRNA NP_001070652 protein Location Chr 19: 0.46 - 0.53 Mb Chr 10: 79.11 - 79.12 Mb Pubmed search 1 2 Basigin is a member of the immunoglobulin superfamily that is also known as EMMPRIN, short for extracellular matrix metalloproteinase inducer, and recently has been designated CD147 cluster of differentiation 147.12 Basigin is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition Miyauchi et al., 1991; Kanekura et al., 1991.supplied by OMIM3 This protein is a determinant for the Ok blood group system. It has a variety of functions. In addition to its metalloproteinase-inducing ability, basigin also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes.2 Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin CyP proteins Cyp-A and CyP-B and certain integrins.456 It is expressed by many cell types, including epithelial cells, endothelial cells and leukocytes. The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion.2 References ^ Kasinrerk W, Fiebiger E, Stefanová I, Baumruker T, Knapp W, Stockinger H 1992. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. J Immunol 149 3: 847-54. PMID 1634773. ^ a b c Yurchenko V, Constant S, Bukrinsky M 2006. Dealing with the family: CD147 interactions with cyclophilins. Immunology 117 3: 301-9. doi:10.1111/j.1365-2567.2005.02316.x. PMID 16476049. ^ Entrez Gene: BSG basigin Ok blood group. ^ Yurchenko V, Zybarth G, O'Connor M, Dai W, Franchin G, Hao T, Guo H, Hung H, Toole B, Gallay P, Sherry B, Bukrinsky M 2002. Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J Biol Chem 277 25: 22959-65. doi:10.1074/jbc.M201593200. PMID 11943775. ^ Yurchenko V, O'Connor M, Dai W, Guo H, Toole B, Sherry B, Bukrinsky M 2001. CD147 is a signaling receptor for cyclophilin B. Biochem Biophys Res Commun 288 4: 786-8. doi:10.1006/bbrc.2001.5847. PMID 11688976. ^ Berditchevski F, Chang S, Bodorova J, Hemler M 1997. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J Biol Chem 272 46: 29174-80. doi:10.1074/jbc.272.46.29174. PMID 9360995. Further reading Muramatsu T, Miyauchi T 2004. Basigin CD147: a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion.. Histol. Histopathol. 18 3: 981-7. PMID 12792908. Yan L, Zucker S, Toole BP 2005. Roles of the multifunctional glycoprotein, emmprin basigin; CD147, in tumour progression.. Thromb. Haemost. 93 2: 199-204. doi:10.1267/THRO05020199. PMID 15711733. Kasinrerk W, Fiebiger E, Stefanová I, et al. 1992. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule.. J. Immunol. 149 3: 847-54. PMID 1634773. Miyauchi T, Masuzawa Y, Muramatsu T 1992. The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen.. J. Biochem. 110 5: 770-4. PMID 1783610. Nabeshima K, Lane WS, Biswas C 1991. Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor.. Arch. Biochem. Biophys. 285 1: 90-6. PMID 1846736. Biswas C, Zhang Y, DeCastro R, et al. 1995. The human tumor cell-derived collagenase stimulatory factor renamed EMMPRIN is a member of the immunoglobulin superfamily.. Cancer Res. 55 2: 434-9. PMID 7812975. Kaname T, Miyauchi T, Kuwano A, et al. 1993. Mapping basigin BSG, a member of the immunoglobulin superfamily, to 19p13.3.. Cytogenet. Cell Genet. 64 3-4: 195-7. PMID 8404035. DeCastro R, Zhang Y, Guo H, et al. 1996. Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.. J. Invest. Dermatol. 106 6: 1260-5. PMID 8752667. Spring FA, Holmes CH, Simpson KL, et al. 1997. The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues.. Eur. J. Immunol. 27 4: 891-7. PMID 9130641. Berditchevski F, Chang S, Bodorova J, Hemler ME 1997. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6.. J. Biol. Chem. 272 46: 29174-80. PMID 9360995. Guo H, Majmudar G, Jensen TC, et al. 1998. Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.. Gene 220 1-2: 99-108. PMID 9767135. Guo H, Li R, Zucker S, Toole BP 2000. EMMPRIN CD147, an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface.. Cancer Res. 60 4: 888-91. PMID 10706100. Kirk P, Wilson MC, Heddle C, et al. 2000. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.. EMBO J. 19 15: 3896-904. doi:10.1093/emboj/19.15.3896. PMID 10921872. Yurchenko V, O'Connor M, Dai WW, et al. 2001. CD147 is a signaling receptor for cyclophilin B.. Biochem. Biophys. Res. Commun. 288 4: 786-8. doi:10.1006/bbrc.2001.5847. PMID 11688976. Yurchenko V, Zybarth G, O'Connor M, et al. 2002. Active site residues of cyclophilin A are crucial for its signaling activity via CD147.. J. Biol. Chem. 277 25: 22959-65. doi:10.1074/jbc.M201593200. PMID 11943775. Kanekura T, Chen X, Kanzaki T 2002. Basigin CD147 is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts.. Int. J. Cancer 99 4: 520-8. doi:10.1002/ijc.10390. PMID 11992541. Major TC, Liang L, Lu X, et al. 2002. Extracellular matrix metalloproteinase inducer EMMPRIN is induced upon monocyte differentiation and is expressed in human atheroma.. Arterioscler. Thromb. Vasc. Biol. 22 7: 1200-7. PMID 12117738. Taylor PM, Woodfield RJ, Hodgkin MN, et al. 2002. Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A2 and 5-lipoxygenase catalyzed pathway.. Oncogene 21 37: 5765-72. doi:10.1038/sj.onc.1205702. PMID 12173047. Thorns C, Feller AC, Merz H 2002. EMMPRIN CD 174 is expressed in Hodgkin's lymphoma and anaplastic large cell lymphoma. An immunohistochemical study of 60 cases.. Anticancer Res. 22 4: 1983-6. PMID 12174874. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. External links Ok blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH v d e Proteins: clusters of differentiation see also list of human clusters of differentiation 1-50 CD1 a-c, 1A, 1D, 1E - CD2 - CD3 γ, δ, ε - CD4 - CD5 - CD6 - CD7 - CD8 a - CD9 - CD10 - CD11 a, b, c - CD13 - CD14 - CD15 - CD16 A, B - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 A, B - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 a, b, c, d - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 a, b, c, d, e, f - CD50 51-100 CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 E, L, P - CD63 - CD64 - CD66 a, b, c, d, e, f - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 a, b - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 a, d, e, h, j, k - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100 101-150 CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 a, b - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 a, b - CD121 a, b - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150 151-200 CD151 - CD152 - CD153 - CD154 - CD155 - CD156 a, b, c - CD157 - CD158 a, d, e, i, k - CD159 a, c - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 a, b - CD168 - CD169 - CD170 - CD171 - CD172 a, b, g - CD174 - CD177 - CD178 - CD179 a, b - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200 201-250 CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 a, b - CD212 - CD213a 1, 2 - CD217 - CD218 a, b - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 a, b - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249 251-300 CD252 - CD253 - CD254 - CD256 - CD257 - CD258 - CD261 - CD262 - CD264 - CD265 - CD266 - CD267 - CD268 - CD269 - CD271 - CD272 - CD273 - CD274 - CD275 - CD276 - CD278 - CD279 - CD280 - CD281 - CD282 - CD283 - CD284 - CD286 - CD288 - CD289 - CD290 - CD292 - CDw293 - CD294 - CD295 - CD297 - CD298 - CD299 301-350 CD300A - CD304 - CD305 - CD307 - CD309 - CD312 - CD314 - CD315 - CD316 - CD317 - CD318 - CD320 - CD321 - CD322 - CD324 - CD325 - CD326 - CD328 - CD329 - CD331 - CD332 - CD333 - CD334 - CD335 - CD336 - CD337 - CD338 - CD339 - CD340 - CD344 - CD349 - CD350 v d e Proteins: complement system C, L, A Activators CLA: C3-convertase - C5-convertase - MAC C6, C7, C8, C9 - L: Mannan-binding lectin - A: Factor P/Properdin Enzymes C: C1Q/C1R/C1S - C4 C4a - C2 - CLA: C3 C3a, C3b/iC3b - C5 C5a - L: MASP1 - MASP2 - A: Complement factor B - Factor D Inhibitors CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H Complement receptors CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin C3a, C5a This article on a gene on chromosome 19 is a stub. Retrieved from http://en..org/wiki/Basigin Categories: Genes on chromosome 19 | Human proteins | Complement system | Clusters of differentiation | Blood | Transfusion medicine | Hematology | Blood antigen systems | Chromosome 19 gene stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 18 July 2008, at 09:2
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