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20-September-2008 09:55:54 - Other red cell antigens In addition to the defined Human blood group systems, there are erythrocyte antigens which do not meet the definition of a blood group system. Most of these are either nearly universal in human blood or extremely rare and are rarely significant in a clinical setting. Reagents to test for these antigens are difficult to find and many cannot be purchased commercially. Contents 1 Blood Group Collections 1.1 Cost 1.2 Er 1.3 Vel 2 Other high-incidence antigens 3 Other low incidence antigens 4 References Blood Group Collections These three groups are antigens with shared characteristics but do not meet the ISBT definition of a human blood group system. Further research may identify them as blood group systems. Cost The Knops blood group system was formerly part of this collection. All that remains are the Csa and Csb antigens. Csa is a very high frequency 98% antigen and Csb is not uncommon ~34%. Er The Er collection includes one high incidence 99% antigen, Era and one 1% rare antigen, Erb. Vel The Vel collection includes the high incidence Vel and ABTI antigens. Antibodies to Vel have been implicated in transfusion reactions. Other high-incidence antigens These antigens are almost universally present on human red cells, but their absence has been noted in some individuals and some have been associated with transfusion reactions or other problems. Finding compatible units for transfusion to a patient that lacks one of these antigens is a major challenge and some countries maintain rare donor registries specifically for that purpose. Lan antigen: anti-Lan is IgG and has been associated with transfusion reactions. A weaker variant of the antigen has also been reported. Ata Antigen: only found in people of African descent. Associated with hemolytic transfusion reactions but not hemolytic disease of the newborn. Jra Antigen: mostly found in Japan. Not associated with acute transfusion reactions. AnWj Antigen: the receptor for Haemophilus influenzae. Implicated in severe hemolytic transfusion reactions. Sda Antigen: This antigen is present on cells other than red cells and is less frequent but still very common. It may be associated with transfusion reactions, but not hemolytic disease of the newborn. Other low incidence antigens These antigens are extremely rare and are of little concern in selecting compatible units for transfusion. They may be implicated in rare cases of hemolytic disease of the newborn, however. Batty By Biles Bi Box Bxa Christiansen Chra HJK HOFM JFV JONES Jensen Jea Katagiri Kg Livesay Lia Milne Oldeide Ola Peters Pta Rasmussen RASM Reid Rea REIT SARA Torkildsen Toa Bg Bennett-Goodspeed: These are actually Human Leukocyte Antigens that cause confusing results on serological tests of erythrocytes. References Mark E. Brecher, or 2005, AABB Technical Manual, fifteenth ion, Bethesda, MD: AABB, ISBN 1-56935-19607, p. 355 v d e Transfusion medicine General concepts Apheresis Plasmapheresis, Plateletpheresis, Leukapheresis - Blood transfusion - Coombs test - Cross-matching - Exchange transfusion - International Society of Blood Transfusion - Intraoperative blood salvage - ISBT 128 - Transfusion reactions Human blood group systems - Blood type ABO - Chido-Rodgers - Colton - Cromer - Diego - Dombrock - Duffy - Gerbich - GIL - Hh - Ii - Indian - JMH - Kell Xk - Kidd - Knops - LW - Lewis - Lutheran - MNS - OK - P - Raph - Rh - Scianna - T-Tn - Xg - Yt - Other Blood products Blood donation - Blood substitutes - Cryoprecipitate - Platelets - Plasma - Red blood cells - Whole blood Retrieved from http://en..org/wiki/Other_red_cell_antigens Categories: Blood | Hematology | Transfusion medicine | Blood antigen systems Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 7 August 2008, at 02:13
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