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20-September-2008 09:55:49 - Pargyline This article or section needs sources or references that appear in reliable, third-party publications. Primary sources and sources affiliated with the subject of the article are generally not sufficient for a article. Please include more appropriate citations from reliable sources, or discuss the issue on the talk page. December 2007 Pargyline Systematic IUPAC name N-Benzyl-N-methyl-prop-2-yn-1-amine Identifiers CAS number 555-57-7 ATC code C02KC01 C02LL01 PubChem 4688 Chemical data Formula C11H13N Mol. mass 195.69 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes ? Pargyline is a monoamine oxidase B MAO-B inhibitor. It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis.1 References ^ Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006 v d e Antihypertensives C02 and diuretics C03 Sympatholytic agents Centrally acting/antiadrenergics α2 agonist Clonidine, Guanfacine, Methyldopa imidazoline receptor agonist Moxonidine, Rilmenidine adrenergic uptake inhibitor Rescinnamine, Reserpine Ganglion-blocking/nicotinic antagonist Mecamylamine, Trimethaphan Peripherally acting/antiadrenergics α1 blockers: Prazosin Indoramin Trimazosin Doxazosin Urapidil Guanidine derivatives: Betanidine Guanethidine Guanoxan Debrisoquine Guanoclor Guanazodine Guanoxabenz Vasodilators Diazoxide hydrazinophthalazine Hydralazine, Dihydralazine, Endralazine, Cadralazine Minoxidil Nitroprusside Phentolamine Other antihypertensives serotonin antagonist Ketanserin endothelin receptor antagonist Bosentan, Ambrisentan, Sitaxsentan MAOI Pargyline THI Metirosine Diuretics Low ceiling Thiazides at DCT Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Chlorothiazide Polythiazide Trichlormethiazide Cyclopenthiazide Methyclothiazide Cyclothiazide Mebutizide Sulfonamides Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone Other Mersalyl Theobromine Cicletanine osmotic Mannitol, Urea carbonic anhydrase inhibitor at PT Acetazolamide High ceiling Loop diuretic at AL Bumetanide, Furosemide, Torasemide, Ethacrynic acid Potassium-sparing at CD ESC blockers Amiloride, Triamterene aldosterone antagonists Spironolactone, Eplerenone, Potassium canrenoate, Canrenone v d e Psychoanaleptics: antidepressants N06A MAOIs Clorgiline Iproclozide Iproniazid Isocarboxazid Minaprine Nialamide Pargyline Phenelzine Toloxatone Tranylcypromine MAOB: Rasagiline Selegiline RIMAs: Befloxatone Brofaromine Cimoxatone Beta-carbolines Harmaline Moclobemide RIs S RI SS RI Alaproclate, Citalopram, Dapoxetine, Escitalopram, Femoxetine, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine TCAs/Tetras Cianopramine, Clomipramine, Nefazodone, Trazodone N RI / A RI Atomoxetine Ciclazindol Maprotiline Nisoxetine Oxaprotiline Reboxetine Talopram Viloxazine TCAs/Tetras Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dosulepin, Doxepin, Imipramine, Iprindole, Melitracen, Nitroxazepine, Nortriptyline, Protriptyline, Trimipramine D RI Medifoxamine Phenmetrazine Vanoxerine TCAs Amineptine SN RI Bicifadine Clovoxamine Desvenlafaxine Duloxetine Milnacipran Nefazodone Venlafaxine ND RI Bupropion Nomifensine SND RI Brasofensine Diclofensine Tesofensine SSREs Tianeptine AAs Tetras Mianserin, Mirtazapine Tablets This pharmacology-related article is a stub. Retrieved from http://en..org/wiki/Pargyline Categories: Alkynes | Aromatic amines | Monoamine oxidase inhibitors | Pharmacology stubsHidden categories: Articles lacking reliable references from December 2007 | All articles lacking sources Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 17 July 2008, at 23:0
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