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News About Phenyltoloxamine

20-September-2008 09:55:57 - Phenyltoloxamine Phenyltoloxamine Systematic IUPAC name 2-2-benzylphenoxy-N,N-dimethylethanamine Identifiers CAS number 92-12-6 ATC code ? PubChem 7077 Chemical data Formula C17H21NO Mol. mass 255.359 Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status OTCUS Routes oral Phenyltoloxamine is an antihistamine with sedative and analgesic effects. It is a member of the ethanolamine class of antihistaminergic agents and a potent anticholinergic, with 55 per cent of the anti-muscarinic potency of atropine. Common use Phenyltoloxamine is widely used in preparations as an enhancing agent for some analgesics and antitussives acetaminophen, codeine, hydrocodone. It is widely used in certain parts of the world as cough suppressant usually with codeine. It is also used to discourage abuse in certain opiate analgesics due its unpleasant side effects at high doses. While therapeutic doses of phenyltoloxamine can generate mild euphoria as can many of its chemical relatives, much higher doses have a side effect profile similar to that of atropine, which is also used in this fashion for tablets of diphenoxylate and morphine for oral administration. Adverse effects Common adverse effects are those associated with most anticholinergics, effects are more pronounced in children and the elderly. See also: anticholinergic Availability Phenyltoloxamine is available in most countries, though it is rare in several western countries it remains widely used around the world, particularly in the developing world. It is not a controlled substance; however some preparations contain opiates such as codeine or hydrocodone and are controlled, when used in preparations with acetaminophen is generally over the counter. Phenyltoloxamine is sold under wide variety of preparations, brand names and dosages around the world: Ed-Flex, Dologesic, Flextra-650, Novagesic, Phenylgesic - North America Codipront - Europe/South America v d e Histamine antagonists H1 or non-selective Alkylamines Bepotastine Bamipine Brompheniramine Chlorpheniramine Dexbrompheniramine Dexchlorpheniramine Dimethindene Metron S Pheniramine Pyrrobutamine Talastine Thenaldine Tolpropamine Triprolidine Ethanolamines Aminoalkyl ethers Bietanautine Bromazine/Bromodiphenhydramine Carbinoxamine Chlorphenoxamine Clemastine Diphenylpyraline Diphenhydramine Doxylamine Embramine p-Methyldiphenhydramine Moxastine Orphenadrine Phenyltoloxamine Setastine Ethylenediamines Chloropyramine Chlorothen Histapyrrodine Methafurylene Mepyramine Methapyrilene Pyrilamine Talastine Thenyldiamine Thonzylamine Tripelennamine Pyribenzamine Phenothiazine Tricyclics Ahistan Etymemazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Thiazinamium Other Tricyclics Azatadine Clobenzepam Cyproheptadine Deptropine Isothipendyl Loratidine Piperazine Buclizine Chlorcyclizine Cinnarizine Clocinizine Hydroxyzine Niaprazine Oxatomide Benzhydryl compounds Cyclizine, Meclizine Others including selective, 2nd gen, 3rd gen Antazoline Astemizole Azatadine Azelastine Bepottastine Bamipine Cetoxine Clemizole Clobenztropine Deptropine Desloratadine Dimebon Ebastine Emedastine Epinastine Ketotifen Levocabastine Loratadine Mebhydrolin Mizolastine Phenindamine Pimethixene Pyrrobutamine Rupatadine Thenalidine Tritoqualine Alkylamine Acrivastine Tricyclic Olopatadine Piperazine Levocetirizine, Cetirizine Benzhydryl compounds Fexofenadine, Terfenadine H2 Cimetidine Famotidine Ranitidine Roxatidine Lafutidine Niperotidine Nizatidine H3 A-349,821 ABT-239 Burimamide Ciproxifan Clobenpropit Conessine Impentamine Iodophenpropit Thioperamide VUF-5681 H4 JNJ 7777120 Thioperamide VUF-6002 Retrieved from http://en..org/wiki/Phenyltoloxamine Categories: Antihistamines Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 01:23

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