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20-September-2008 09:55:51 - Piribedil Piribedil Systematic IUPAC name 2-4-benzo1,3dioxol-5-ylmethylpiperazin-1-ylpyrimidine Identifiers CAS number 3605-01-4 ATC code N04BC08 PubChem 4850 Chemical data Formula C16H18N4O2 Mol. mass 298.340 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life 1.7 - 6.9 hours Excretion Renal 68% and biliary 25% Therapeutic considerations Pregnancy cat. ? Legal status Routes Oral Piribedil is a piperazine dopamine agonist; and marketed as TRIVASTAL Retard 50. Trivastal retard 50 is also distributed as: Trastal, Trivastal 50 retard, Trivastal 50mg LP, Trivastan ritardo and Pronoran. Official site Contents 1 Composition: 2 Indications: 3 Dosage: 4 Adverse: 5 Overdosage: Composition: Piribedil 50 mg per tablet - sustained-release. Indications: - Treatment of Parkinson's disease, either as monotherapy without L-dopa or in combination with L-dopa therapy, in the early stages as well as in the advanced stages. - Treatment of pathological cognitive deficits in the elderly impaired attention, memory, etc. Treatment of dizziness in the elderly. - Treatment of Retinal ischemic manifestations. Adjuvant treatment in intermittent claudication due to peripheral occlusive arterial disease of the lower limbs stage 2. - off label anhedonia and treatment-resistant depression in unipolar and bipolar depressives Dosage: In Parkinson's disease: administration of Trivastal retard 50 should be initiated with 1 tablet daily during the first week. Dosage should then be gradually increased every week until achieving the optimal therapeutic dose: as monotherapy: 3 to 5 tablets in 3 to 5 divided doses daily. In combination with L-dopa therapy: 1 to 3 tablets daily. In other indications: 1 tablet daily at the end of the main meal. In severe cases: 2 tablets daily as 2 divided doses. Trivastal retard 50 is a nonergot dopamine agonist, selective for D2 and D3 dopamine receptors subtypes at the cerebral and at the peripheral level. Cardiogenic shock. Acute phase of myocardial infarction. Adverse: rare side effects: minor gastrointestinal disorders nausea, vomiting, flatulence in predisposed individuals, or when taken between meals. They may resolve with the following: individual dosage adjustment, and/or addition of domperidone. Orthostatic hypotension or drowsiness may occur, particularly in predisposed individuals underlying condition or causative illness. Dopaminergic antagonists. Overdosage: At very high doses, Trivastal retard 50 has an emetic action on the CTZ chemoreceptive trigger zone. Tablets will thus be rapidly rejected, which explains why no data are currently available concerning the risk of overdosage. Tablets This pharmacology-related article is a stub. v d e Anti-parkinson drugs: dopaminergic agents N04B Dopa and derivatives Droxidopa Levodopa Melevodopa Etilevodopa Adamantane derivatives Amantadine Dopamine agonists A-412,997 Apomorphine Bromocriptine Cabergoline Dihydrexidine Dihydroergocryptine mesylate Fenoldopam Lisuride Pergolide Piribedil Pramipexole Propylnorapomorphine Quinpirole Ropinirole Rotigotine SKF 38393 SKF 82958 MAOIs B Selegiline Rasagiline COMT inhibitors Entacapone Tolcapone Other Budipine dopa decarboxylase inhibitor Carbidopa Retrieved from http://en..org/wiki/Piribedil Categories: Pharmacology stubs | Piperazines Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch This page was last modified on 1 May 2008, at 14:17
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