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20-September-2008 09:55:49 - Potassium-sparing diuretic Potassium-sparing diuretic refers to diuretic drugs that do not promote the secretion of potassium into the urine. They are used as adjunctive therapy, together with other drugs, in the treatment of hypertension and management a congestive heart failure. Contents 1 Mechanism of action 2 Indications 3 Side effects 4 Chemical structure 5 See also 6 External links 7 References Mechanism of action Potassium-Sparing Diuretics eg Amiloride aoyene for intracellular cytoplasmic receptor sites. This prevents the production of proteins that are normally synthesized in reaction to aldosterone. These mediator proteins are not produced, and so stimulation of sodium-potassium exchange sites in the collection tubule does not occur. This prevents sodium readsorption and potassium and hydrogen ion secretion.1 Indications Potassium-sparing diuretics are generally used in combination with other diuretic drugs e.g. loop diuretics that would otherwise tend to lower the potassium levels to potentially dangerous low levels hypokalemia. The combination therefore helps maintain a normal reference range for potassium. Side effects On their own this group of drugs may raise potassium levels beyond the normal range, termed hyperkalemia, which risks potentially fatal arrhythmias. Chemical structure Pota aldosterone antagonists. Those in clinical use include: Amiloride Triamterene Aldosterone antagonists: Spironolactone Eplerenone See also C03D Potassium-sparing agents External links MeSH Potassium+Sparing+Diuretics References Block JH, Beale JM. Organic Medicinal and Pharmaceutical Chemistry 11th ion. Lippincott Williams Wilkins. 2004. v d e Antihypertensives C02 and diuretics C03 Sympatholytic agents Centrally acting/antiadrenergics α2 agonist Clonidine, Guanfacine, Methyldopa imidazoline receptor agonist Moxonidine, Rilmenidine adrenergic uptake inhibitor Rescinnamine, Reserpine Ganglion-blocking/nicotinic antagonist Mecamylamine, Trimethaphan Peripherally acting/antiadrenergics α1 blockers: Prazosin Indoramin Trimazosin Doxazosin Urapidil Guanidine derivatives: Betanidine Guanethidine Guanoxan Debrisoquine Guanoclor Guanazodine Guanoxabenz Vasodilators Diazoxide hydrazinophthalazine Hydralazine, Dihydralazine, Endralazine, Cadralazine Minoxidil Nitroprusside Phentolamine Other antihypertensives serotonin antagonist Ketanserin endothelin receptor antagonist Bosentan, Ambrisentan, Sitaxsentan MAOI Pargyline THI Metirosine Diuretics Low ceiling Thiazides at DCT Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Chlorothiazide Polythiazide Trichlormethiazide Cyclopenthiazide Methyclothiazide Cyclothiazide Mebutizide Sulfonamides Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone Other Mersalyl Theobromine Cicletanine osmotic Mannitol, Urea carbonic anhydrase inhibitor at PT Acetazolamide High ceiling Loop diuretic at AL Bumetanide, Furosemide, Torasemide, Ethacrynic acid Potassium-sparing at CD ESC blockers Amiloride, Triamterene aldosterone antagonists Spironolactone, Eplerenone, Potassium canrenoate, Canrenone Retrieved from http://en..org/wiki/Potassium-sparing_diuretic Categories: Potassium-sparing diuretics | Cardiology Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Español Nederlands This page was last modified on 19 July 2008, at 06:45
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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