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20-September-2008 09:55:56 - Propylhexedrine Propylhexedrine Systematic IUPAC name N,α-dimethyl-cyclohexylethylamine Identifiers CAS number 3595-11-7 ATC code ?? ? PubChem 7558 DrugBank ? Chemical data Formula C10H21N Mol. mass 155.29 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. C Legal status Unscheduled US Federal Schedule varies US States Schedule V Canada Exempted from the application of the CDSA Routes Nasal inhaler Propylhexedrine, also known as hexahydrodesoxyephedrine or dimethylcyclohexaneethanamine, is a sympathomimetic with varied medicinal uses, is an adrenergic compound used mainly to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis. Being a vasoconstrictor used to decongest nasal mucosa, it is administered by inhalation. Propylhexedrine is most commonly found in over the counter Benzedrex inhalers and is similar to norepinephrine and epinephrine 1. Benzedrex was first manufactured by Smith, Kline and French after the Benzedrine inhaler which contained amphetamine, became unavailable after the placement of amphetamines on Schedule II status highest abuse potential of all legal drugs. Contents 1 Recreational use 2 Chemistry 3 See also 4 Notes Recreational use These inhalers have been occasionally used by people for their stimulant effects which are believed by some to be similar to methamphetamine. This is done by removing the cotton rod from the inhaler and putting it in capsules, mixing it with soda or some other drink, and some occasionally swallow it. Each cotton contains 250 mg quarter-gram of propylhexedrine. An equally potent alternate method is soaking the cotton rod in acidic solution, such as acetic acid vinegar, ascorbic acid otherwise known as Vitamin C, citric acid, or even stronger acids such as hydrochloric acid and sulfuric acid, thereby forming a solution of active propylhexderine salt for e.g. propylhexedrine citrate. Propylhexedrine is of significantly less risk of being used recreationally than amphetamines. This is primarily because propylhexedrine has limited methods of use, unlike amphetamines. The abuse potential is low enough that neither the DEA nor the WHO consider it a drug of concern, unlike ephedrine or its salts. However, attempts to extract the drug from the nasal inhaler and then inject it have been known. Abuse by injection is dangerous and could result in death, which has been recorded.1 2 As with similar drugs, using propylhexedrine to keep oneself awake for extended amounts of time can lead to a temporary state of sleep deprivation possibly similar to an amphetamine psychosis during which an individual may experience hallucinations of all kinds as well as extreme paranoia, all common effects associated with sleep deprivation. The most sought-after effect is a general state of well-being and happiness associated with stimulants. The effects vary from person to person. Many people suffer adverse effects after using the drug, feeling sick and nauseated. It is a vasoconstrictor, so ingestion can cause nausea and serious gastrointestinal issues, though the majority of the adverse effects are assumed to occur due to the cotton and what users call 'menthol burps'. Propylhexedrine has strong physical effects as well as it's mental effects, propylhexedrine can raise blood pressure and heart rate significantly and individuals that are currently on stimulants prescription or not, taking an MAOI or have high blood pressure or otherwise cardiac problems should avoid propylhexedrine for recreational use. As with similar stimulants, it is possible to overdose on the substance and extremely unwise to combine with any other drug that raises blood pressure. Eating cotton for any reason is not at all a healthy practice, and though not necessarily fatal, can still lead to severe gastrointestinal problems, which may require medical attention. Gastric blockages and even internal infection can occur if too much cotton is routinely ingested in a short space of time. On a less serious note, cramps, gas, and temporary constipation can also occur. Chemistry Propylhexedrine is structurally similar to methamphetamine. The only difference is that the phenyl group of the methamphetamine molecule is swapped with a cyclohexyl group. It is because of this that propylhexedrine is not an amphetamine, nor even a phenethylamine. It is most like methamphetamine in terms that it contains a methyl CH3 group in positions Rα and RN. See also amphetamine cyclopentamine methamphetamine ephedrine phenyl vs. cyclohexyl phenethylamine Benzedrine Notes ^ Proposed Rules . Federal Register 50 10: 2226 - 2227. ^ Prince v. Ascher, 90 P.3d 1020 2004. v d e Stimulants Alkylamines Cyclopentamine Geranamine Isometheptene Octodrine Propylhexedrine Tuamine Alphapyrrolidinylalkiophenones α-PPP MDPPP MDPV MPBP MPHP MPPP MOPPP Pyrovalerone Cholinergics ABT-089 ABT-418 Anabasine Arecoline Cotinine Cytisine Dianicline Epibatidine Epiboxidine GTS-21 Ispronicline Nicotine Rivanicline Tebanicline Varenicline Convulsants Bicuculline DMCM Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil Carphedon Modafinil Phenethylamines 4-Bromomethcathinone 4-Fluoroamphetamine 4-Fluoromethamphetamine 4-Fluoromethcathinone 4-Methylmethcathinone 4-MTA Aletamine Amfepentorex Amphechloral Amphetamine Dextroamphetamine, Adderall Amphetaminil Benzphetamine Bupropion Cathinone Chlorphentermine Clenbuterol Clobenzorex Clortermine Diethylpropion Dimethoxyamphetamine Dimethylamphetamine Dimethylcathinone Ephedrine Epinephrine Ethcathinone Ethylamphetamine Fenethylline Fenfluramine Fenproporex Fludorex Furfenorex Levomethamphetamine Lisdexamfetamine MDMA Mefenorex Methamphetamine Methcathinone Methoxyphedrine Methylone Octopamine Ortetamine Parahydroxyamphetamine PCA PIA PMA PMEA PMMA PPAP Phendimetrazine Phenmetrazine Phentermine Phenylephrine Phenylpropanolamine Propylamphetamine Pseudoephedrine Selegiline Synephrine Tiflorex Xylopropamine Phenylaminooxazoles 4-Methyl-aminorex Aminorex Clominorex Fenozolone Fluminorex Pemoline Thozalinone Piperazines 2C-B-BZP BZP GBR-12783 GBR-12935 GBR-13069 GBR-13098 GBR-13119 MeOPP MBZP Vanoxerine Piperidines 2-Benzylpiperidine Desoxypipradrol Diphemethoxidine Ethylphenidate HDMP-28 --Methyl-1-methyl-4β-2-naphthylpiperidine-3β-carboxylate Methylphenidate Dexmethylphenidate Nocaine Phacetoperane Pipradrol Tropanes 3α-Bis-4-fluorophenylmethoxytropane 3α-4-Chlorophenylphenylmethoxytropane 3-Pseudotropyl-4-fluorobenzoate Altropane IACFT Brasofensine CFT WIN 35,428 β-CIT RTI-55 Cocaethylene Cocaine β-CPPIT Dichloropane RTI-111 Difluoropine FE-β-CPPIT FP-β-CPPIT PIT PTT RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-121 IPCIT RTI-126 RTI-150 RTI-171 RTI-177 RTI-336 Tesofensine Troparil β-CPT, WIN 35,065-2 WF-23 WF-33 WF-60 Xanthines Aminophylline Caffeine Dimethazan Paraxanthine Theobromine Theophylline Others Amineptine Bemegride Benzydamine BPAP Bromantane BTQ Clofenciclan Cypenamine Cyprodenate Diclofensine Dimethocaine Diphenyl prolinol Ethamivan Fencamfamine Feprosidnine Gilutensin GYKI-52895 Hexacyclonate Indanorex Indatraline LR-5182 Mazindol Mesocarb Naphthylisopropylamine Nikethamide Nomifensine Phthalimidopropiophenone Prolintane Sibutramine Yohimbine Zylofuramine See also Sympathomimetic amines Retrieved from http://en..org/wiki/Propylhexedrine Categories: Stimulants Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Polski This page was last modified on 6 August 2008, at 03:5
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