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20-September-2008 09:55:55 - CD151 Redirected from Raph antigen system CD151 molecule Raph blood group Identifiers Symbols CD151; GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24 External IDs OMIM: 602243 MGI: 1096360 HomoloGene: 20916 Gene ontology Molecular function: protein binding Cellular component: membrane fraction plasma membrane integral to plasma membrane integral to membrane Biological process: cell adhesion visual perception sensory perception of sound RNA expression pattern 250px More reference expression data Orthologs Human Mouse Entrez 977 12476 Ensembl ENSG00000177697 ENSMUSG00000025510 Uniprot P48509 Q921J7 Refseq NM_001039490 mRNA NP_001034579 protein NM_009842 mRNA NP_033972 protein Location Chr 11: 0.82 - 0.83 Mb Chr 7: 141.32 - 141.32 Mb Pubmed search 1 2 CD151 molecule Raph blood group, also known as CD151 Cluster of Differentiation 151, is a human gene.1 The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.1 See also Cluster of differentiation Tetraspanin References ^ a b Entrez Gene: CD151 CD151 molecule Raph blood group. Further reading Berditchevski F 2002. Complexes of tetraspanins with integrins: more than meets the eye.. J. Cell. Sci. 114 Pt 23: 4143-51. PMID 11739647. Ashman LK 2003. CD151.. J. Biol. Regul. Homeost. Agents 16 3: 223-6. PMID 12456024. Ashman LK, Aylett GW, Mehrabani PA, et al. 1992. The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen.. Br. J. Haematol. 79 2: 263-70. PMID 1958484. Fitter S, Tetaz TJ, Berndt MC, Ashman LK 1995. Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3.. Blood 86 4: 1348-55. PMID 7632941. Maruyama K, Sugano S 1994. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.. Gene 138 1-2: 171-4. PMID 8125298. Hasegawa H, Utsunomiya Y, Kishimoto K, et al. 1996. SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily.. J. Virol. 70 5: 3258-63. PMID 8627808. Hasegawa H, Kishimoto K, Yanagisawa K, et al. 1997. Assignment of SFA-1 PETA-3, a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization.. Genomics 40 1: 193-6. doi:10.1006/geno.1996.4563. PMID 9070943. Sincock PM, Mayrhofer G, Ashman LK 1997. Localization of the transmembrane 4 superfamily TM4SF member PETA-3 CD151 in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin.. J. Histochem. Cytochem. 45 4: 515-25. PMID 9111230. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. 1997. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.. Gene 200 1-2: 149-56. PMID 9373149. Fitter S, Seldin MF, Ashman LK 1998. Characterisation of the mouse homologue of CD151 PETA-3/SFA-1; genomic structure, chromosomal localisation and identification of 2 novel splice forms.. Biochim. Biophys. Acta 1398 1: 75-85. PMID 9602068. Sincock PM, Fitter S, Parton RG, et al. 1999. PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function.. J. Cell. Sci. 112 Pt 6: 833-44. PMID 10036233. Serru V, Le Naour F, Billard M, et al. 1999. Selective tetraspan-integrin complexes CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1 under conditions disrupting tetraspan interactions.. Biochem. J. 340 Pt 1: 103-11. PMID 10229664. Testa JE, Brooks PC, Lin JM, Quigley JP 1999. Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin PETA-3/CD151 as an effector of human tumor cell migration and metastasis.. Cancer Res. 59 15: 3812-20. PMID 10447000. Sterk LM, Geuijen CA, Oomen LC, et al. 2000. The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.. J. Cell Biol. 149 4: 969-82. PMID 10811835. Whittock NV, McLean WH 2001. Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene.. Biochem. Biophys. Res. Commun. 281 2: 425-30. doi:10.1006/bbrc.2001.4384. PMID 11181065. Charrin S, Le Naour F, Oualid M, et al. 2001. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.. J. Biol. Chem. 276 17: 14329-37. doi:10.1074/jbc.M011297200. PMID 11278880. Suzuki Y, Tsunoda T, Sese J, et al. 2001. Identification and characterization of the potential promoter regions of 1031 kinds of human genes.. Genome Res. 11 5: 677-84. doi:10.1101/gr.164001. PMID 11337467. Kohno M, Hasegawa H, Miyake M, et al. 2002. CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase.. Int. J. Cancer 97 3: 336-43. PMID 11774285. Zhang XA, Kazarov AR, Yang X, et al. 2002. Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis.. Mol. Biol. Cell 13 1: 1-11. doi:10.1091/mbc.01-10-0481. PMID 11809818. This membrane protein-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Proteins: clusters of differentiation see also list of human clusters of differentiation 1-50 CD1 a-c, 1A, 1D, 1E - CD2 - CD3 γ, δ, ε - CD4 - CD5 - CD6 - CD7 - CD8 a - CD9 - CD10 - CD11 a, b, c - CD13 - CD14 - CD15 - CD16 A, B - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 A, B - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 a, b, c, d - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 a, b, c, d, e, f - CD50 51-100 CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 E, L, P - CD63 - CD64 - CD66 a, b, c, d, e, f - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 a, b - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 a, d, e, h, j, k - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100 101-150 CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 a, b - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 a, b - CD121 a, b - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150 151-200 CD151 - CD152 - CD153 - CD154 - CD155 - CD156 a, b, c - CD157 - CD158 a, d, e, i, k - CD159 a, c - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 a, b - CD168 - CD169 - CD170 - CD171 - CD172 a, b, g - CD174 - CD177 - CD178 - CD179 a, b - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200 201-250 CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 a, b - CD212 - CD213a 1, 2 - CD217 - CD218 a, b - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 a, b - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249 251-300 CD252 - CD253 - CD254 - CD256 - CD257 - CD258 - CD261 - CD262 - CD264 - CD265 - CD266 - CD267 - CD268 - CD269 - CD271 - CD272 - CD273 - CD274 - CD275 - CD276 - CD278 - CD279 - CD280 - CD281 - CD282 - CD283 - CD284 - CD286 - CD288 - CD289 - CD290 - CD292 - CDw293 - CD294 - CD295 - CD297 - CD298 - CD299 301-350 CD300A - CD304 - CD305 - CD307 - CD309 - CD312 - CD314 - CD315 - CD316 - CD317 - CD318 - CD320 - CD321 - CD322 - CD324 - CD325 - CD326 - CD328 - CD329 - CD331 - CD332 - CD333 - CD334 - CD335 - CD336 - CD337 - CD338 - CD339 - CD340 - CD344 - CD349 - CD350 Retrieved from http://en..org/wiki/CD151 Categories: Genes on chromosome 11 | Human proteins | Membrane protein stubs | Clusters of differentiationHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on
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