Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 09:55:51 - Selegiline Selegiline Systematic IUPAC name N-methyl-N-1-methyl-2-phenyl-ethyl-prop-2-yn-1-amine Identifiers CAS number 14611-51-9 14611-52-0 HCl, 2079-54-1 deprenyl.HCl, 4530-70-5 +--isomer, 1205-70-5 +--isomer, HCl, 2323-36-6 cpd w/o isomeric designation; deprenyl, 4528-51-2 S-isomer, 4528-52-3 S-isomer, HCl ATC code N04BD01 PubChem 26757 DrugBank APRD00525 Chemical data Formula C13H17N Mol. mass 187.281 g/mol Pharmacokinetic data Bioavailability 4.4% Protein binding 99.5% Metabolism liver Half life 2 hours Excretion ? Therapeutic considerations Pregnancy cat. C US Legal status prescription only unscheduled US Routes Oral, transdermally Selegiline l-deprenyl, Eldepryl, Zelapar, or Anipryl veterinary is a drug used for the treatment of early-stage Parkinson's disease, depression and senile dementia. In normal clinical doses it is a selective irreversible MAO-B inhibitor, however in larger doses it loses its specificity and also inhibits MAO-A. Dietary restrictions are common for MAOI treatments, but since selegiline is selective for MAO-B, special dietary restrictions for lower doses have been found to be unnecessary.1 The drug was researched by Knoll József. Selegiline belongs to a class of drugs called phenethylamines. Selegiline consists of a phenethylamine skeleton with a propargyl group attached to the nitrogen atom. Contents 1 Uses 2 Pharmacology 2.1 Pharmacokinetics 2.1.1 Metabolites 2.1.1.1 Desmethylselegiline 2.1.1.2 L-amphetamine and L-methamphetamine 2.2 Mechanism of Action 3 Legal Issues 4 Emsam 5 Zelapar 6 References 7 External links Uses It is sometimes used off-label to treat narcolepsy and as a nootropic, as well as for its published life-extending effects among several species of mammals. It is also reported to positively affect libido, particularly in older males.citation needed As of February 28, 2006, selegiline has also been approved by the Food and Drug Administration FDA to treat major depression using a transdermal patch Emsam Patch.2 Selegiline is also used at extremely high dosages relative to humans in veterinary medicine to treat the symptoms of Cushing's disease and so-called cognitive dysfunction in dogs.citation needed As of June 26, 2006, a selegiline transdermal patch is being tested for its effectiveness in treating ADHD.citation needed Several clinical studies are currently underway to evaluate Selegiline's effectiveness in helping people stop smoking tobacco or marijuana.34 Pharmacology Pharmacokinetics Please help improve this section by expanding it with: please add citations detailing bioavailability. Further information might be found on the talk page or at requests for expansion. June 2008 Selegiline has a low oral bioavailability. Selegiline's oral bioavailability is drastically increased in females taking oral contraceptives 10- to 20-fold.5 This could lead to loss of MAO-B selectivity, which in turn would make patients suspectible to the usual risks of unselective MAOIs such as tyramine-induced hypertensive crisis and serotonin toxicity when combined with serotonergics such as SSRIs.5 Metabolites Desmethylselegiline Desmethylselegiline may have neuroprotective antiapoptotic properties. A large multicenter study suggests a decrease of in the disease progression of parkinsonism but may have reflected other symptomatic response.6 Desmethylselegiline is metabolized by CYP2C19.7 L-amphetamine and L-methamphetamine Selegiline is partly metabolized to l-methamphetamine, a stereoisomer of methamphetamine in vivo.8 A characteristic metabolic pattern was noted, exemplified by a ratio of 1-methamphetamine to 1-amphetamine of about 2.8.9 This stereoisomer is not considered psychoactive and has little abuse potential.10 The stimulatory effect on locomotor activity and dopamine synthesis may be contributed to by the action of l-methamphetamine. Due to this metabolite selegiline can cause false positives for amphetamine/methamphetamine on drug tests. Mechanism of Action Selegiline is a selective inhibitor of MAO-B; MAO-B metabolizes dopamine.11 Selegiline exhibits little therapeutic benefit when used independently, but enhances and prolongs the anti-Parkinson effects of levodopa.12 Legal Issues Possibly due to the structural similarity to illegal stimulants, selegiline has been classified as a controlled substance in Japan and thus can only be obtained with a prescription or special government license. Selegiline is not a controlled substance in the US but a prescription is required to obtain it. Emsam February 28, 2006 - The Food and Drug Administration approved Emsam selegiline, the first skin transdermal patch for use in treating major depression. The once a day patch works by delivering selegiline, a monoamine oxidase inhibitor or MAOI, through the skin and into the bloodstream. At its lowest strength, Emsam can be used without the dietary restrictions that are needed for all oral MAO inhibitors that are approved for treating major depression. It comes in three sizes that deliver 6, 9, or 12 mg of selegiline per 24 hours. The patch is a matrix containing three layers consisting of a backing, and adhesive drug layer, and a release liner that is placed against the skin. EMSAM was developed by Somerset Pharmaceuticals, Inc. In December 2004, Bristol-Myers Squibb and Somerset entered into an agreement that provides Bristol-Myers Squibb with distribution rights to market EMSAM after approval in the United States. Zelapar Zelapar is a transmucosal preparation for human administration of selegiline. The quickly-dissolving lozenge is placed between cheek and gum and the medication enters the bloodstream directly. Because hepatic first-pass metabolism is bypassed, the effective dose is lower than oral swallowed selegiline. GI side effects are reportedly reduced compared to oral swallowed selegiline. Zelapar is manufactured by Valeant Pharmaceuticals 1. References ^ Amsterdam, J. D. 2003-02. A double-blind, placebo-controlled trial of the safety and efficacy of selegiline transdermal system without dietary restrictions in patients with major depressive disorder. Journal of Clinical Psychiatry 64 2: 208-214. ^ FDA Approves Emsam Selegiline as First Drug Patch for Depression ^ Effectiveness of Selegiline in Treating Marijuana Dependent Individuals. ClinicalTrials.gov. National Institute on Drug Abuse March 2005. Retrieved on 2007-02-16. ^ Usefulness of Selegiline as an Aid to Quit Smoking. ClinicalTrials.gov. National Institute on Drug Abuse July 2004. Retrieved on 2007-02-16. ^ a b Laine K, Anttila M, Helminen A, Karnani H, Huupponen R March 1999. Dose linearity study of selegiline pharmacokinetics after oral administration: evidence for strong drug interaction with female sex steroids. Br J Clin Pharmacol 47 3: 249-54. PMID 10215747. PMC:2014223. ^ Katzung, Bertram G. Basic Clinical Pharmacology. 9th ion. 2004. page 453. Lange Medical Books - McGraw Hill Publishers. ^ http://www.blackwell-synergy.com/doi/abs/10.1034/j.1600-0773.2000.d01-38.x Selegiline Metabolism and Cytochrome P450 Enzymes ^ Engberg G, Elebring T, Nissbrandt H 1991. Deprenyl selegiline, a selective MAO-B inhibitor with active metabolites; effects on locomotor activity, dopaminergic neurotransmission and firing rate of nigral dopamine neurons. J. Pharmacol. Exp. Ther. 259 2: 841-7. PMID 1658311. ^ www.astm.org/JOURNALS/FORENSIC/PAGES/2587.htm ^ Are metabolites of l-deprenyl selegiline useful ...J Neural Transm Suppl. 1996 - PubMed Result ^ Katzung, Bertram G. Basic Clinical Pharmacology. 9th ion. 2004. page 453. Lange Medical Books - McGraw Hill Publishers. ^ Katzung. Page 453 External links Collection of Research Abstracts on Deprenyl An Interview with Dr. Joseph Knoll regarding longevity Deprenyl Improves Learning And Memory Deprenyl Selegiline Can Slow Parkinson's Disease Safely According to the British Medical Journal FDA Approves Emsam Selegiline as First Drug Patch for Depression v d e Anti-parkinson drugs: dopaminergic agents N04B Dopa and derivatives Droxidopa Levodopa Melevodopa Etilevodopa Adamantane derivatives Amantadine Dopamine agonists A-412,997 Apomorphine Bromocriptine Cabergoline Dihydrexidine Dihydroergocryptine mesylate Fenoldopam Lisuride Pergolide Piribedil Pramipexole Propylnorapomorphine Quinpirole Ropinirole Rotigotine SKF 38393 SKF 82958 MAOIs B Selegiline Rasagiline COMT inhibitors Entacapone Tolcapone Other Budipine dopa decarboxylase inhibitor Carbidopa v d e Psychoanaleptics: antidepressants N06A MAOIs Clorgiline Iproclozide Iproniazid Isocarboxazid Minaprine Nialamide Pargyline Phenelzine Toloxatone Tranylcypromine MAOB: Rasagiline Selegiline RIMAs: Befloxatone Brofaromine Cimoxatone Beta-carbolines Harmaline Moclobemide RIs S RI SS RI Alaproclate, Citalopram, Dapoxetine, Escitalopram, Femoxetine, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine TCAs/Tetras Cianopramine, Clomipramine, Nefazodone, Trazodone N RI / A RI Atomoxetine Ciclazindol Maprotiline Nisoxetine Oxaprotiline Reboxetine Talopram Viloxazine TCAs/Tetras Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dosulepin, Doxepin, Imipramine, Iprindole, Melitracen, Nitroxazepine, Nortriptyline, Protriptyline, Trimipramine D RI Medifoxamine Phenmetrazine Vanoxerine TCAs Amineptine SN RI Bicifadine Clovoxamine Desvenlafaxine Duloxetine Milnacipran Nefazodone Venlafaxine ND RI Bupropion Nomifensine SND RI Brasofensine Diclofensine Tesofensine SSREs Tianeptine AAs Tetras Mianserin, Mirtazapine Retrieved from http://en..org/wiki/Selegiline Categories: Nootropics | Monoamine oxidase inhibitors | Antiparkinsonian agents | PhenethylaminesHidden categories: All articles with statements | Articles with statements since December 2007 | Articles to be expanded since June 2008 | All articles to be expanded Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Magyar Nederlands Polski РуÑ?Ñ?кий Svenska This page was last modified on 20 August 2008, at 16:39
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie video
The Power of You video
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.