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20-September-2008 09:55:58 - Sulbutiamine Sulbutiamine Systematic IUPAC name 4-4-amino-2-methyl-pyrimidin-5-ylmethyl-formyl- amino-3-2-4-amino-2-methyl-pyrimidin-5-ylmethyl- formyl-amino-5-2-methylpropanoyloxypent-2-en-3- yldisulfanyl-pent-3-enyl 2-methylpropanoate Identifiers CAS number 3286-46-2 ATC code A11DA02 PubChem 71124 Chemical data Formula C32H46N8O6S2 Mol. mass 702.89 g/mol SMILES eMolecules PubChem Synonyms Arcalion, bisibuthiamine, youvitan Pharmacokinetic data Bioavailability ? Metabolism ? Half life 5 hours Excretion Renal Therapeutic considerations Pregnancy cat. ? Legal status Routes Oral Sulbutiamine brand name: Arcalion is a precursor to thiamine i.e., vitamin B1. Contents 1 Uses 2 Effects 3 Dosage 4 Mechanisms of action 5 References 6 External links Uses It is indicated for the treatment of asthenia.1 Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats2 and patients of schizophrenia2 suggests that it is a nootropic. New research show support for use in erectile dysfunction 3 Effects Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.4 Dosage Sulbutiamine is sometimes supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg,2 which corresponds to 850 mg for a 68 kg 150 lb person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day. Mechanisms of action Sulbutiamine crosses the blood brain barrier more easily than vitamin B1 because of its lipophilic properties. It leads to an increased formation of thiamine triphosphate TTP that acts as a regulator of the synaptic transmission of many neurotransmission systems. Sulbutiamine is a thiamine derivative which has two different properties in comparison with vitamin B1 as a result of structural modification of free thiamine, namely opening of the thiazole ring, esterification of the alcohol groups and dimerization, with formation of a disulfide bridge. References ^ Shah SN; Sulbutiamine Study Group 2003. Adjuvant role of vitamin B analogue sulbutiamine with anti-infective treatment in infection associated asthenia.. J Assoc Physicians India 51: 891-5. PMID 14710977. ^ a b c Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H 2005. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task.. Prog Neuropsychopharmacol Biol Psychiatry 29 6: 928-35. doi:10.1016/j.pnpbp.2005.04.035. PMID 15951087. ^ Urologiia. 2005 Jan-Feb;1:32-5. Clinical efficacy of the drug enerion sulbutiamine in the treatment of patients with psychogenic functional erectile dysfunction Dmitriev DG, Gamidov SI, Permiakova OV. ^ Serdia Pharmaceuticals | About Serdia | Product Portfolio | Arcalion External links New Drugs that Make you Smart by John Morgenthaler at hoboes.com v d e Vitamins A11 Fat soluble A: Retinol - Beta-carotene - Tretinoin - Alpha-carotene D3: 7-Dehydrocholesterol → Previtamin D3 → Cholecalciferol D3 → Calcidiol → Calcitriol active form → Calcitroic acid D2: Ergosterol → Ergocalciferol D2 D analogues: Dihydrotachysterol - Calcipotriol - Tacalcitol E: Tocopherol - Tocotrienol K: Naphthoquinone - Phylloquinone/K1 - Menatetrenone/K2 Water soluble: B vitamins B1 Thiamine - B2 Riboflavin - B3 Niacin, Nicotinamide - B5 Pantothenic acid, Dexpanthenol, Pantethine - B6 Pyridoxine, Pyridoxal phosphate, Pyridoxamine - B7 Biotin - B9 Folic acid, Folinic acid - B12 Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide Water soluble: other C Ascorbic acid - Choline see also enzyme cofactors v d e Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics N06B Centrally acting sympathomimetics Amphetamine - Amphetaminil - Atomoxetine - Dextroamphetamine - Dextromethamphetamine - Fencamfamin - Fenozolone - Fenetylline - Methylphenidate - Mesocarb - Pemoline - Pipradrol - Prolintane Xanthine derivatives Caffeine - Propentofylline Glutamate receptor Racetams Aniracetam - Nefiracetam - Oxiracetam - Phenylpiracetam - Piracetam - Pramiracetam Ampakines CX-516 - CX-546 - CX-614 - CX-691 - CX-717 - IDRA-21 - LY-503,430 - PEPA Eugeroics / Benzhydryl compounds Adrafinil - Armodafinil - Modafinil Histamine H3 receptor antagonists ABT-239 - Ciproxifan Other psychostimulants and nootropics Acetylcarnitine - Citicoline - Cyprodenate - Idebenone - Ispronicline - Deanol - Dimebon - Fipexide - Linopirdine - Meclofenoxate - Nizofenone - Pirisudanol - Pyritinol - Sulbutiamine - Taltirelin - Tricyanoaminopropene - Vinpocetine Retrieved from http://en..org/wiki/Sulbutiamine Categories: Aromatic amines | Aromatic compounds | Nootropics | Pyrimidines Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Français Türkçe This page was last modified on 10 July 2008, at 02:28
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