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20-September-2008 09:55:58 - Swiss-Prot Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.1 Swiss-Prot strives to provide reliable protein sequences associated with a high level of annotation such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc., a minimal level of redundancy and high level of integration with other databases. In 2002, the UniProt consortium was created: it is a collaboration between the Swiss Institute of Bioinformatics, the European Bioinfomatics Institute and the Protein Information Resource PIR, funded by the National Institutes of Health. Swiss-Prot and its automatically curated supplement TrEMBL, have joined with the Protein Information Resource protein database to produce the UniProt Knowledgebase, the world's most comprehensive catalogue of information on proteins.2 As of 3 April 2007, UniProtKB/Swiss-Prot release 52.2 contains 263,525 entries. As of 3 April 2007, the UniProtKB/TrEMBL release 35.2 contains 4,232,122 entries. The UniProt consortium produced 3 database components, each optimised for different uses. The UniProt Knowledgebase UniProtKB Swiss-Prot + TrEMBL, the UniProt Non-redundant Reference UniRef databases, which combine closely related sequences into a single record to speed similarity searches and the UniProt Archive UniParc, which is a comprehensive repository of protein sequences, reflecting the history of all protein sequences. References ^ Bairoch Amos 2000. Serendipity in bioinformatics, the tribulations of a Swiss bioinformatician through exciting times!. Bioinformatics 16: 48-64. doi:10.1093/bioinformatics/16.1.48. PMID 10812477. - a historical account by Bairoch. ^ Wu, C.H. et al. January 2006 The Universal Protein Resource UniProt: an expanding universe of protein information.. Nucleic Acids Research, 1;34 Database issue: D187-91. Séverine Altairac, Naissance d'une banque de données: Interview du prof. Amos Bairoch. Protéines à la Une, August 2006. ISSN 1660-9824. External links Swiss-Prot Protein Database Swiss Institute of Bioinformatics UniProt Swiss Institute of Bioinformatics Retrieved from http://en..org/wiki/Swiss-Prot Categories: Bioinformatics databases | Science and technology in Europe Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Español Italiano Nederlands This page was last modified on 21 June 2008, at 16:04
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