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News About Taltirelin

20-September-2008 09:55:58 - Taltirelin Taltirelin Systematic IUPAC name 4S-N-2S-1-2S-2-carbamoylpyrrolidin-1-yl-3-3H-imidazol-4-yl-1-oxopropan-2-yl-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide Identifiers CAS number 103300-74-9 201677-75-0 ATC code ? PubChem 656609 Chemical data Formula C17H31N7O9 Mol. mass 477.46 g/mol SMILES eMolecules PubChem Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes Oral Taltirelin marketed under the tradename Ceredist is a thyrotropin-releasing hormone TRH analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects,1 and little development of tolerance following prolonged dosing.2 It has nootropic,3 neuroprotective4 and analgesic effects,5 and is primarily being researched for the treatment of Spinocerebellar ataxia. Tablets This pharmacology-related article is a stub. References ^ Fukuchi I, Asahi T, Kawashima K, et al April 1998. Effects of taltirelin hydrate TA-0910, a novel thyrotropin-releasing hormone analog, on in vivo dopamine release and turnover in rat brain. Arzneimittelforschung 48 4: 353-9. PMID 9608876. ^ Asai H, Asahi T, Yamamura M, Yamauchi-Kohno R, Saito A. Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats. Pharmacology, Biochemistry and Behaviour. 2005 Dec;824:646-51. PMID 16368129 ^ Yamamura M, Suzuki M, Matsumoto K. Synthesis and pharmacological action of TRH analog peptide Taltirelin. Nippon Yakurigaku Zasshi. Japanese. 1997 Oct;110 Suppl 1:33P-38P. PMID 9503402 ^ Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y. Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone TRH analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sciences. 2002 Dec 20;724-5:601-7. PMID 12467901 ^ Tanabe M, Tokuda Y, Takasu K, Ono K, Honda M, Ono H. The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. British Journal of Pharmacology. 2007 Feb;1504:403-14. PMID 17220907 Japanese Ceredist セレジスト錠 PDF Mitsubishi Tanabe Pharma. October 2007. External links Japanese Official Mitsubishi Tanabe Pharma Website v d e Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics N06B Centrally acting sympathomimetics Amphetamine - Amphetaminil - Atomoxetine - Dextroamphetamine - Dextromethamphetamine - Fencamfamin - Fenozolone - Fenetylline - Methylphenidate - Mesocarb - Pemoline - Pipradrol - Prolintane Xanthine derivatives Caffeine - Propentofylline Glutamate receptor Racetams Aniracetam - Nefiracetam - Oxiracetam - Phenylpiracetam - Piracetam - Pramiracetam Ampakines CX-516 - CX-546 - CX-614 - CX-691 - CX-717 - IDRA-21 - LY-503,430 - PEPA Eugeroics / Benzhydryl compounds Adrafinil - Armodafinil - Modafinil Histamine H3 receptor antagonists ABT-239 - Ciproxifan Other psychostimulants and nootropics Acetylcarnitine - Citicoline - Cyprodenate - Idebenone - Ispronicline - Deanol - Dimebon - Fipexide - Linopirdine - Meclofenoxate - Nizofenone - Pirisudanol - Pyritinol - Sulbutiamine - Taltirelin - Tricyanoaminopropene - Vinpocetine Retrieved from http://en..org/wiki/Taltirelin Categories: Pharmacology stubs | Nootropics Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 29 June 2008, at 12:16

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