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20-September-2008 09:55:50 - Thick ascending limb of loop of Henle Redirected from Thick ascending limb Thick ascending limb of loop of Henle Scheme of renal tubule and its vascular supply. Labeled at center left. Nephron. Diagram is labeled in Polish, but ion flow can still be identified. Latin tubulus rectus distalis Gray's subject #253 1223 Dorlands/Elsevier t_22/12830078 The thick ascending limb of loop of Henle or distal straight tubule is a segment of the nephron in the kidney. It can be divided into two parts: that in the renal medulla, and that in the renal cortex. Medullary thick ascending limb The medullary thick ascending limb remains impermeable to water. Sodium, potassium K+ and chloride Cl- ions are reabsorbed by active transport. K+ is passively transported along its concentration gradient through a K+ leak channel in the apical aspect of the cells, back into the lumen of the ascending limb. This K+ leak generates a positive electrochemical potential difference in the lumen. The electrical gradient drives more reabsorption of Na+, as well as other cations such as magnesium Mg2+ and importantly calcium Ca2+. Loop diuretics such as furosemide block the K+/Na+/2Cl- co-transporter. Urea which remains in the loop creates a solute potential that prevents water completely osmosing out into the interstitial space. This means that while almost all the ions are reabsorbed, there will still be some water in the urine, and hence, the concentration of the filtrate in the loop is decreased here. If only ions were present, and a certain amount of ions were reabsorbed, one would expect the same amount of the water to be reabsorbed too, and hence the concentration would remain the same, but this is not true. This is also the part of the tubule that generates Tamm-Horsfall protein. The function of this protein is not well understood, but is responsible for creating urinary casts. Cortical thick ascending limb The difference between the medullary and cortical thick ascending limbs is mainly anatomical. Functionally, they are very similar. The cortical thick ascending limb drains urine into the distal convoluted tubule. External links Physiology at MCG 7/7ch07/7ch07p11 Histology at BU 15804loa Overview at vet.cornell.edu This article was originally based on an entry from a public domain ion of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please the article if this is the case, and feel free to remove this notice when it is no longer relevant. This anatomy article is a stub. v d e Urinary system - Kidney Layers Renal fascia Renal capsule Renal cortex Renal column Renal medulla Renal sinus, Renal pyramids, medullary interstitium Renal lobe Cortical lobule Medullary ray Nephron Afferent circulation Renal artery → Segmental arteries → Interlobar arteries → Arcuate arteries → Cortical radial arteries → Afferent arterioles → Renal corpuscle Glomerulus, Bowman's capsule Renal tubule Proximal tubule → Loop of Henle Descending, Thin ascending, Thick ascending → Distal convoluted tubule → Connecting tubule → Collecting ducts → Duct of Bellini → Renal papilla → Minor calyx → Major calyx → Renal pelvis → Ureter Efferent circulation Glomerulus → Efferent arterioles → Peritubular capillaries / Vasa recta → Arcuate vein → Interlobar veins → Renal vein Juxtaglomerular apparatus Macula densa Juxtaglomerular cells Mesangium/Extraglomerular mesangial cell Filtration Glomerular basement membrane Podocyte Filtration slits Mesangium/Intraglomerular mesangial cell Tubular fluid Renal physiology Acid base physiology Fluid balance Retrieved from http://en..org/wiki/Thick_ascending_limb_of_loop_of_Henle Categories: Anatomy stubs | Kidney Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages 日本語 This page was last modified on 4 August 2008, at 02:33
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