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20-September-2008 09:55:50 - Thirst For other uses, see Thirst disambiguation. William-Adolphe Bouguereau's Thirst 1886 William-Adolphe Bouguereau's Thirst 1886 Thirst is the craving for liquids, resulting in the basic instinct of humans or animals to drink. It is an essential mechanism involved in fluid balance. It arises from a lack of fluids and/or an increase in the concentration of certain osmolites such as salt. If the water volume of the body falls below a certain threshold, or the osmolite concentration becomes too high, the brain signals thirst. Continuous dehydration can cause myriad problems, but is most often associated with neurological problems such as seizures, and renal problems. Excessive thirst, known as polydipsia, along with excessive urination, known as polyuria, may be an indication of diabetes. There are receptors and other systems in the body that detect a decreased volume or an increased osmolite concentration. They signal to the central nervous system, where central processing succeeds. Some sources1 therefore distinguish extracellular thirst from intracellular thirst, where extracellular thirst is thirst generated by decreased volume and intracellular thirst is thirst generated by increased osmolite concentration. Nevertheless, the craving itself is something generated from central processing in the brain, no matter how it is detected. Contents 1 Detection 1.1 Decreased volume 1.2 Increased osmolite concentration 1.3 Salt craving 1.4 Senior citizens 2 Central processing 3 Preventing subtle dehydration 4 See also 5 References Detection There are many different receptors for sensing decreased volume or an increased osmolite concentration. Decreased volume Further reading: Hypovolemia Renin-angiotensin system Hypovolemia leads to activation of the renin angiotensin system RAS and a decrease in atrial natriuretic peptide. These mechanisms, along their other functions, contribute to elicit thirst, by affecting the subfornical organ.2. For instance, angiotensin II, activated in RAS, is a powerful dipsogen ie it stimulates thirst which acts via the subfornical organ. Other Arterial baroreceptors sense a decreased arterial pressure, and signals to the central nervous system in the area postrema2 and nucleus tractus solitarius2. Cardiopulmonary receptors sense a decreased blood volume, and signal to area postrema2 and nucleus tractus solitarius2 as well. Increased osmolite concentration Main article: Osmoreceptor An increase in osmotic pressure, e.g. after eating a salty meal1 activates osmoreceptors. There are osmoreceptors already in the central nervous system, more specifically in the hypothalamus, notably in two circumventricular organs that lack an effective blood-brain barrier, the organum vasculosum of the lamina terminalis OVLT and the subfornical organ SFO. However, although located in the same parts of the brain, these osmoreceptors that evoke thirst are distinct from the neighbouring osmoreceptors in the OVLT and SFO that evoke arginine vasopressin release to decrease fluid output.3 In addition, there are visceral osmoreceptors2. These project to the area postrema2 and nucleus tractus solitarius2 in the brain. Salt craving Because sodium is also lost from the plasma in hypovolemia, the body's need for salt proportionately increases in addition to thirst in such cases1. This is also a result of the renin-angiotensin system activation. Senior citizens For adults over age 50, the body's thirst sensation diminishes and continues diminishing with age, causing many to suffer symptoms of dehydration. Central processing The area postrema and nucleus tractus solitarius signal, by 5-HT2, to lateral parabrachial nucleus2, which in turn signal to median preoptic nucleus. In addition, the area postrema and nucleus tractus solitarius also signal directly to subfornical organ.2 Thus, the median preoptic nucleus and subfornical organ receive signals of both decreased volume and increased osmolite concentration. They signal to higher integrative centers2, where ultimately the conscious craving arises. However, the true neuroscience of this conscious craving is not fully clear. In addition to thirst, the organum vasculosum of the lamina terminalis and the subfornical organ contribute to fluid balance by vasopressin release. Preventing subtle dehydration For optimal health, experts recommend that humans get 8-10 servings of about 8-ounces of water in total, approximately 2 litres per day to maintain hydration.citation needed This figure does vary according to ambient temperature, movement and physical size. Being that water is essential to the general function of the human and all animal bodies, eight servings is widely regarded as the minimum for the body to function optimally. However, water can be obtained from many sources, such as foods and other beverages containing water. Getting enough water from your diet and staying hydrated is key to your overall health, including urinary tract and digestive tract health. When getting your daily water intake, it is important to not rely heavily on caffeinated beverages, as they actually work as a diuretic. Further, moderate or excessive alcohol consumption can lead to dehydration, thus it is important to maintain hydration when drinking caffeinated and alcoholic beverages. See also Look up Thirst in Wiktionary, the free dictionary. Hunger Dehydration References ^ a b c Carlson, N. R. 2005. Foundations of Physiological Psychology: Custom ion for SUNY Buffalo. Boston, MA: Pearson Custom Publishing. ^ a b c d e f g h i j k l M.J. McKinley and A.K. Johnson 2004. The Physiological Regulation of Thirst and Fluid Intake. News in Physiological Sciences 19 1: 1-6. doi:10.1152/nips.01470.2003. PMID 14739394. Retrieved on 2006-06-02. ^ Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 872 Retrieved from http://en..org/wiki/Thirst Categories: Food and drinkHidden categories: All articles with statements | Articles with statements since April 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Avañe'ẽ Deutsch Español Français í•œêµì–´ עברית Latina Nederlands Polski Runa Simi РуÑ?Ñ?кий Basa Sunda Suomi Svenska УкраїнÑ?ька This page was last modified on 21 August 2008, at 05:35
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