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20-September-2008 09:55:58 - Tricyanoaminopropene Tricyanoaminopropene Systematic IUPAC name 2-aminoprop-1-ene-1,1,3-tricarbonitrile Identifiers CAS number 868-54-2 ATC code ? PubChem 13356 Chemical data Formula C6H4N4 Mol. mass 132.123 g/mol SMILES eMolecules PubChem Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes ? Tricyanoaminopropene TRIAP, TCAP, Malononitrile Dimer, 1,1,3-tricyano-2-amino-1-propene is a nootropic drug which mimics the function of nerve growth factor and increases the growth of nerves and tissue regeneration both in isolated tissues1 and in vivo. It stimulates the action of the enzyme choline acetyltransferase, resulting in increased acetylcholine production.2 This then results in increased synthsis of RNA in many different tissues in the body. 3 However it also suppresses the production of thyroxine, causing temporary hypothyroidism which returns to normal once the drug is discontinued.4 Tricyanoaminopropene reduces the amnesia produced by electroconvulsive shock,5 and animal tests suggested nootropic activity,678 but no beneficial effect was found when it was tested in retarded children,9 and administration to pregnant rats actually reduced learning ability in their young because of its anti-thyroid hormone effects.10 This drug thus produces two effects which oppose each other, with the nootropic effect from the increased acetylcholine production cancelled out by the opposite effect produced by the decrease in production of thyroxine. It is not known whether the efficacy of the drug could be improved by supplementation with additional thyroxine or equivalent drugs. Tablets This pharmacology-related article is a stub. References ^ Paul JW, Quach TT, Duchemin AM, Schrier BK, DaVanzo JP. 1,1,3 tricyano-2-amino-1-propene Triap: a small molecule which mimics or potentiates nerve growth factor. Brain Research. Developmental Brain Research. 1990 Aug 1;551:21-7. PMID 2208638 ^ Paul JW, DaVanzo JP. 1,1,3 Tricyano-2-amino-1-propene Triap stimulates choline acetyltransferase activity in vitro and in vivo. Brain Research. Developmental Brain Research. 1992 Jun 19;672:113-20. PMID 1511511 ^ Dhindsa KS, Enesco HE. Radioautographic study of the effect of malononitrile dimer on RNA synthesis in mice. Acta Anatomica Basel. 1978;1001:44-50. PMID 899675 ^ Dhindsa KS. Histological changes in the thyroid gland of the mouse following treatment with 1, 1, 3-tricyano-2-amino-1-propene. Acta Anatomica Basel. 1980;1064:468-72. PMID 7386168 ^ Essman WB. Effect of tricyanoaminopropene on the amnesic effect of electroconvulsive shock. Psychopharmacology Berlin. 1966 Jan;95:426-433 doi:10.1007/BF00406452. ^ Rahwan RG. The biochemical and pharmacological basis of learning and memory. Inflammation Research. 1971 Aug;22:87-102. ^ Banfi S, Cornelli U, Fonio W, Dorigotti L. A screening method for substances potentially active on learning and memory. Journal of Pharmacological Methods. 1982 Dec;84:255-63. PMID 7154677 ^ STUDIES OF THE EFFECTS OF MANIPULATION OF BRAIN METABOLISM ON LEARNING. I. VITAMIN B12. II. MAGNESIUM PEMOLINE CYLERT. III. MALONONITRILE DIMER U9189. IV. ANODAL POLARIZATION. ^ Panzer JD, Atkinson WH. Tricyanoaminopropene TCAP: Lack of Improvement of Mentation in Mentally Retarded Children. Psychosomatics. 1969 Mar-Apr;102:136-40. PMID 4181970 ^ Davenport JW. Cretinism in Rats: Enduring Behavioral Deficit Induced by Tricyanoaminopropene. Science 1970 Feb;1673920:1007-1009. v d e Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics N06B Centrally acting sympathomimetics Amphetamine - Amphetaminil - Atomoxetine - Dextroamphetamine - Dextromethamphetamine - Fencamfamin - Fenozolone - Fenetylline - Methylphenidate - Mesocarb - Pemoline - Pipradrol - Prolintane Xanthine derivatives Caffeine - Propentofylline Glutamate receptor Racetams Aniracetam - Nefiracetam - Oxiracetam - Phenylpiracetam - Piracetam - Pramiracetam Ampakines CX-516 - CX-546 - CX-614 - CX-691 - CX-717 - IDRA-21 - LY-503,430 - PEPA Eugeroics / Benzhydryl compounds Adrafinil - Armodafinil - Modafinil Histamine H3 receptor antagonists ABT-239 - Ciproxifan Other psychostimulants and nootropics Acetylcarnitine - Citicoline - Cyprodenate - Idebenone - Ispronicline - Deanol - Dimebon - Fipexide - Linopirdine - Meclofenoxate - Nizofenone - Pirisudanol - Pyritinol - Sulbutiamine - Taltirelin - Tricyanoaminopropene - Vinpocetine Retrieved from http://en..org/wiki/Tricyanoaminopropene Categories: Pharmacology stubs | Nootropics Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 3 July 2008, at 07:14
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