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20-September-2008 09:55:50 - Urea Urea IUPAC name Diaminomethanal Other names Carbamide Identifiers CAS number 57-13-6 SMILES NC=ON Properties Molecular formula NH22CO Molar mass 60.07 g/mol Appearance white odourless solid Density 1.33·10³ kg/m³1, solid Melting point 132.7 °C 406 K decomposes Boiling point n.a. Solubility in water 108 g/100 ml 20 °C 167 g/100 ml 40 °C 251 g/100 ml 60 °C 400 g/100 ml 80 °C 733 g/100 ml 100 °C Acidity pKa 26.9 Basicity pKb 13.82 Structure Dipole moment 4.56 p/D Hazards MSDS ScienceLab.com NFPA 704 1 2 0 Except where noted otherwise, data are given for materials in their standard state at 25 °C, 100 kPa Infobox references Urea is an organic compound with the chemical formula NH22CO. Urea is also known by the International Nonproprietary Name rINN carbamide, as established by the World Health Organization. For example, the medicinal compound hydroxyurea old British Approved Name is now hydroxycarbamide. Other names include carbamide resin, isourea, carbonyl diamide, and carbonyldiamine. Contents 1 Discovery 2 Structure 3 Physiology 3.1 Endogenous production 3.2 Function 3.2.1 In humans 3.2.1.1 Regulation 3.2.2 Non-humans 4 Hazards 5 Synthetic production 5.1 Commercial production 6 Uses 6.1 Agricultural use 6.1.1 Storage of urea fertilizer 6.2 Industrial use 6.3 Further commercial uses 6.4 Laboratory use 6.5 Medical use 6.6 Textile use 6.7 Ionic liquid 6.8 Automobile systems 7 Ureas 8 Reactions 9 References 10 External links Discovery It was the first organic compound to be artificially synthesized from inorganic starting materials, in 1828 by Friedrich Wöhler, who prepared it by the reaction of potassium cyanate with ammonium sulfate. Although Wöhler was attempting to prepare ammonium cyanate, by forming urea, he inadvertently discred vitalism, the theory that the chemicals of living organisms are fundamentally different from inanimate matter, thus starting the discipline of organic chemistry. This discovery prompted Wöhler to write triumphantly to Berzelius: I must tell you that I can make urea without the use of kidneys, either man or dog. Ammonium cyanate is urea. It is found in mammalian and amphibian urine as well as in some fish. Birds and reptiles excrete uric acid, comprising a different form of nitrogen metabolism that requires less water. Structure Urea is highly soluble in water and is, therefore, an efficient way for the human body to expel excess nitrogen. Due to extensive hydrogen bonding with water up to six hydrogen bonds may form - two from the oxygen atom and one from each hydrogen urea is very soluble. The urea molecule is planar and retains its full molecular point symmetry, due to conjugation of one of each nitrogen's P orbital to the carbonyl double bond. Each carbonyl oxygen atom accepts four N-H-O hydrogen bonds,citation needed a very unusual feature for such a bond type. This dense and energetically favourable hydrogen bond network is probably established at the cost of efficient molecular packing: The structure is quite open, the ribbons forming tunnels with square cross-section. Physiology Endogenous production Main article: urea cycle The individual atoms that make up a urea molecule come from carbon dioxide, water, aspartate, and ammonia in a metabolic pathway known as the urea cycle, an anabolic process. Organisms synthesize urea from ammonia because ammonia a common metabolic waste product raises pH in cells to toxic levels. Therefore, urea synthesis is necessary even though it costs energy to produce. Urea is neither acidic nor basic, so it is a perfect vehicle for getting rid of nitrogen waste. Urea production occurs in the liver and is regulated by N-acetylglutamate. In this cycle, amino groups donated by ammonia and L-aspartate are converted to urea, while L-ornithine, citrulline, L-argininosuccinate, and L-arginine act as intermediates. Function In humans Urea is, in essence, a waste product. Urea is the human waste product known as urine. It is found and retracted from urine. However, it also plays a very important role in that it helps set up the countercurrent system in the nephrons. The countercurrent system in the nephrons allows for reabsorption of water and critical ions. Urea is reabsorbed in the inner medullary collecting ducts of the nephrons2, thus raising the osmolarity in the medullary interstitium surrounding the thin ascending limb of the Loop of Henle. The greater the osmolarity of the medullary interstitium surrounding the thin ascending Loop of Henle, the more water will be reabsorbed out of the renal tubule back into the interstitium and thus back into the body. Some of the urea from the meduallary interstitium that helped set up the Countercurrent System will also flow back into the tubule, through urea transporter 2, into the thin ascending limb of the loop of Henle, through the collecting ducts, and eventually out of the body as a component of urine. It is dissolved in blood in a concentration of 2.5 - 7.5 mmol/liter and excreted by the kidney as a component of urine. In addition, a small amount of urea is excreted along with sodium chloride and water in sweat. Regulation Main article: renal urea handling Control of urea by antidiuretic hormone allows the body to create hyperosmotic urine urine that has more ions in it--is more concentrated--than that same person's blood plasma. Preventing the loss of water in this manner is important if the person's body needs to save water in order to maintain a suitable blood pressure or more likely, in order to maintain a suitable concentration of sodium ions in the blood plasma. Non-humans Most organisms have to deal with the excretion of nitrogen waste originating from protein and amino acid catabolism. In aquatic organisms the most common form of nitrogen waste is ammonia, while land-dwelling organisms convert the toxic ammonia to either urea or uric acid. In general, birds and saurian reptiles excrete uric acid, whereas the remaining species, including mammals, excrete urea. It is noteworthy that tadpoles excrete ammonia, and shift to urea production during metamorphosis. Despite the generalization above, the pathway has been documented not only in mammals and amphibians but in many other organisms as well, including birds, invertebrates, insects, plants, yeast, fungi, and even microorganisms. Hazards Urea can be irritating to skin and eyes. Too high concentrations in the blood can cause damage to organs of the body. Low concentrations of urea such as in urine are not dangerous. It has been found that urea can cause algal blooms to produce toxins, and urea in runoff from fertilizers may play a role in the increase of toxic blooms.3 Repeated or prolonged contact with urea in fertilizer form on the skin may cause dermatitis. The substance also irritates the eyes, the skin, and the respiratory tract. The substance decomposes on heating above melting point, producing toxic gases, and reacts violently with strong oxidants, nitrites, inorganic chlorides, chlorites and perchlorates, causing fire and explosion hazard Synthetic production Urea is a nitrogen-containing chemical product that is produced on a scale of some 100,000,000 tons per year worldwide. For use in industry, urea is produced from synthetic ammonia and carbon dioxide. Urea can be produced as prills, granules, flakes, pellets, crystals, and solutions. More than 90% of world production is destined for use as a fertilizer. Urea has the highest nitrogen content of all solid nitrogenous fertilizers in common use 46.7%. Therefore, it has the lowest transportation costs per unit of nitrogen nutrient. Urea is highly soluble in water and is, therefore, also very suitable for use in fertilizer solutions in combination with ammonium nitrate: UAN, e.g., in 'foliar feed' fertilizers. Solid urea is marketed as prills or granules. The advantage of prills is that, in general, they can be produced more cheaply than granules, which, because of their narrower particle size distribution, have an advantage over prills if applied mechanically to the soil. Properties such as impact strength, crushing strength, and free-flowing behaviour are, in particular, important in product handling, storage, and bulk transportation. Commercial production Urea is commercially produced from two raw materials, ammonia, and carbon dioxide. Large quantities of carbon dioxide are produced during the manufacture of ammonia from coal or from hydrocarbons such as natural gas and petroleum-derived raw materials. This allows direct synthesis of urea from these raw materials. The production of urea from ammonia and carbon dioxide takes place in an equilibrium reaction, with incomplete conversion of the reactants. The various urea processes are characterized by the conditions under which urea formation takes place and the way in which unconverted reactants are further processed. Unconverted reactants can be used for the manufacture of other products, for example ammonium nitrate or sulfate, or they can be recycled for complete conversion to urea in a total-recycle process. Two principal reactions take place in the formation of urea from ammonia and carbon dioxide. The first reaction is exothermic: 2 NH3 + CO2 ↔ H2N-COONH4 ammonium carbamate Whereas the second reaction is endothermic: H2N-COONH4 ↔ NH22CO + H2O Both reactions combined are exothermic. The process, developed in 1922, is also called the Bosch-Meiser urea process after its discoverers. Uses Agricultural use Urea is used as a nitrogen-release fertilizer, as it hydrolyses back to ammonia and carbon dioxide, but its most common impurity, biuret, must be present at less than 2%, as it impairs plant growth. It is also used in many multi-component solid fertilizer formulations. Its action of nitrogen release is due to the conditions favouring the reagent side of the equilibriums, which produce urea. Urea is usually spread at rates of between 40 and 300 kg/ha, but actual spreading rates will vary according to farm type and region. It is better to make several small to medium applications at intervals to minimise leaching losses and increase efficient use of the N applied, compared with single heavy applications. During summer, urea should be spread just before, or during rain to reduce possible losses from volatilisation process wherein nitrogen is lost to the atmosphere as ammonia gas. Urea should not be mixed for any length of time with other fertilizers, as problems of physical quality may result. Because of the high nitrogen concentration in urea, it is very important to achieve an even spread. The application equipment must be correctly calibrated and properly used. Drilling must not occur on contact with or close to seed, due to the risk of germination damage. Urea dissolves in water for application as a spray or through irrigation systems. In grain and cotton crops, urea is often applied at the time of the last cultivation before planting. It should be applied into or be incorporated into the soil. In high rainfall areas and on sandy soils where nitrogen can be lost through leaching and where good in-season rainfall is expected, urea can be side- or top-dressed during the growing season. Top-dressing is also popular on pasture and forage crops. In cultivating sugarcane, urea is side-dressed after planting, and applied to each ratoon crop. In irrigated crops, urea can be applied dry to the soil, or dissolved and applied through the irrigation water. Urea will dissolve in its own weight in water, but it becomes increasingly difficult to dissolve as the concentration increases. Dissolving urea in water is endothermic, causing the temperature of the solution to fall when urea dissolves. As a practical guide, when preparing urea solutions for fertigation injection into irrigation lines, dissolve no more than 30 kg urea per 100 L water. In foliar sprays, urea concentrations of 0.5% - 2.0% are often used in horticultural crops. As urea sprays may damage crop foliage, specific advice should be sought before use. Low-biuret grades of urea should be used if urea sprays are to be applied regularly or to sensitive horticultural crops. Storage of urea fertilizer Like most nitrogen products, urea absorbs moisture from the atmosphere. Therefore it should be stored either in closed/sealed bags on pallets, or, if stored in bulk, under cover with a tarpaulin. As with most solid fertilizers, it should also be stored in a cool, dry, well-ventilated area. Industrial use Urea has the ability to form 'loose compounds', called clathrates, with many organic compounds. The organic compounds are held in channels formed by interpenetrating helices comprising of hydrogen-bonded urea molecules. This behaviour can be used to separate mixtures, and has been used in the production of aviation fuel and lubricating oils. As the helices are interconnected, all helices in a crystal must have the same 'handedness'. This is determined when the crystal is nucleated and can thus be forced by seeding. This property has been used to separate racemic mixtures. Further commercial uses A stabilizer in nitrocellulose explosives A reactant in the NOx-reducing SNCR and SCR reactions in exhaust gases from combustion, for example, from power plants and diesel engines A component of fertilizer and animal feed, providing a relatively cheap source of nitrogen to promote growth A raw material for the manufacture of plastics, to be specific, urea-formaldehyde resin A raw material for the manufacture of various glues urea-formaldehyde or urea-melamine-formaldehyde; the latter is waterproof and is used for marine plywood An alternative to rock salt in the de-icing of roadways and runways; it does not promote metal corrosion to the extent that salt does An additive ingredient in cigarettes, designed to enhance flavour A browning agent in factory-produced pretzels An ingredient in some hair conditioners, facial cleansers, bath oils, and lotions A reactant in some ready-to-use cold compresses for first-aid use, due to the endothermic reaction it creates when mixed with water A cloud seeding agent, along with salts, to expe the condensation of water in clouds, producing precipitation An ingredient used in the past to separate paraffins, due to the ability of urea to form clathrates also called host-guest complexes, inclusion compounds, and adducts A flame-proofing agent commonly used in dry chemical fire extinguishers as Urea-potassium bicarbonate An ingredient in many tooth whitening products A cream to soften the skin, especially cracked skin on the bottom of one's feet An ingredient in dish soap. To make potassium cyanate A melt agent used in re-surfacing snowboarding halfpipes and terrain park features Laboratory use Urea is a powerful protein denaturant. This property can be exploited to increase the solubility of some proteins. For this application, it is used in concentrations up to 10 M. Urea is used to effectively disrupt the noncovalent bonds in proteins. Urea is an ingredient in the synthesis of urea nitrate. Urea nitrate is also a high explosive very similar to ammonium nitrate, however it may even be more powerful because of its complexity. VOD is 11,000 fps to 15,420 fps. Medical use Drug use Urea is used in topical dermatological products to promote rehydration of the skin. If covered by an occlusive dressing, 40% urea preparations may also be used for nonsurgical debridement of nails. This drug is also used as an earwax removal aid. Clinical diagnosis Main article: blood urea nitrogen The blood urea nitrogen BUN test is a measure of the amount of nitrogen in the blood that comes from urea. It is used as a marker of renal function. Other diagnostic use Isotopically-labeled urea carbon-14 - radioactive, or carbon-13 - stable isotope is used in the urea breath test, which is used to detect the presence of the bacteria Helicobacter pylori H. pylori in the stomach and duodenum of humans. The test detects the characteristic enzyme urease, produced by H. pylori, by a reaction that produces ammonia from urea. This increases the pH reduces acidity of the stomach environment around the bacteria. Similar bacteria species to H. pylori can be identified by the same test in animals such as apes, dogs, and cats including big cats.vague Textile use Urea in textile laboratories are frequently used both in dyeing and printing as an important auxiliary, which provides solubility to the bath and retains some moisture required for the dyeing or printing process. Ionic liquid Choline chloride, in mixture with urea, is used as a deep eutectic solvent, a type of ionic liquid. Automobile systems The 2009 Mercedes-Benz ML320 diesel model comes with the BlueTEC System to create a zero emissions vehicles. It uses a water-based urea solution known to Mercedes as AdBlue that is injected into the exhaust system and releases ammonia. This gets reacted with the nitrogen oxide emissions and gets converted into nitrogen and water within the catalytic converter. Ureas The term urea or carbamide is also used for the class of chemical compounds sharing the same functional group RR'N-CO-NRR' based on a carbonyl group flanked by two organic amine residues. They can be accessed in the laboratory by reaction of phosgene with primary or secondary amines. Example of ureas are the compounds carbamide peroxide, allantoin, and Hydantoin. Ureas are closely related to biurets and related in structure to amides, carbamates, diimides, carbodiimides, and thiocarbamides. Reactions Urea reacts with alcohols to form urethanes. Urea reacts with malonic esters to make barbituric acids. References ^ Urea Mineral Data ^ Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 837 ^ newscientist.com - US set to track toxic algal blooms External links MSDS sheet on urea Use of urea in hand dyeing use of urea as an automotive reagent to reduce harmful emissions AdBlue v d e E numbers Colours E100-199 Preservatives E200-299 Antioxidants Acidity regulators E300-399 Thickeners, stabilisers emulsifiers E400-499 pH regulators anti-caking agents E500-599 Flavour enhancers E600-699 Miscellaneous E900-999 Additional chemicals E1100-1599 Waxes E900-909 Synthetic glazes E910-919 Improving agents E920-929 Packaging gases E930-949 Sweeteners E950-969 Foaming agents E990-999 L-cysteine E920 L-cystine E921 Potassium persulfate E922 Ammonium persulfate E923 Potassium bromate E924 Chlorine E925 Chlorine dioxide E926 Azodicarbonamide E927 Carbamide E927b Benzoyl peroxide E928 Retrieved from http://en..org/wiki/Urea Categories: Nitrogen metabolism | Ureas | Functional groups | Agricultural chemicals | Excretion | Soil improversHidden categories: All articles with statements | Articles with statements since August 2007 | articles needing clarification Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages العربية БългарÑ?ки Català Česky Dansk Deutsch Eesti Español Esperanto Euskara Français Gaeilge Bahasa Indonesia Ã?slenska Italiano עברית Latina LatvieÅ¡u Lietuvių Magyar Nederlands 日本語 ‪Norsk bokmÃ¥l‬ ‪Norsk nynorsk‬ Occitan Polski Português РуÑ?Ñ?кий SlovenÄ?ina SlovenÅ¡Ä?ina Suomi Svenska తెలà±?à°—à±? Tiếng Việt Türkçe ä¸æ–‡ This page was last modified on 21 August 2008, at 02:51
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