Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
20-September-2008 10:21:22 - Dextromethorphan Dextromethorphan Systematic IUPAC name +-3-methoxy-17-methyl-9α,13α,14α-morphinan Identifiers CAS number 125-71-3 ATC code R05DA09 PubChem 5360696 DrugBank APRD00655 Chemical data Formula C18H25NO Mol. mass 271.4 g/mol SMILES eMolecules PubChem Physical data Melt. point 111 °C 232 °F Pharmacokinetic data Bioavailability 11%1 Metabolism Hepatic liver enzymes: major CYP2D6, minor CYP3A4, and minor CYP3A5 Half life 1.4-3.9 hours Excretion Renal Therapeutic considerations Pregnancy cat. AAU CUS Legal status Pharmacy Only S2AU OTCUS Routes Oral Dextromethorphan DXM or DM is an antitussive cough suppressant drug found in many over-the-counter cold and cough medicines. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychological applications. Pure dextromethorphan occurs as a powder made up of white crystals, but it is generally administered via syrups, tablets, or lozenges manufactured under several different brand names and generic labels. When taken at doses higher than are medically recommended, dextromethorphan acts as a dissociative hallucinogenic drug. It is classified neurochemically as an NMDA receptor antagonist, producing effects similar to those of the controlled substances ketamine and phencyclidine PCP2 Contents 1 Chemistry 2 Indications 3 Pharmacokinetics 4 Side-effects 5 Drug interactions 6 Contraindications 7 Clinical pharmacology 7.1 Nervous system activity 7.2 Metabolism 8 Brand names 9 History 10 Recreational use 11 References 12 See also Chemistry Dextromethorphan is the dextrorotatory enantiomer of the methyl ether of levorphanol, a narcotic analgesic. It is also a stereoisomer of levomethorphan, an opioid analgesic. It is named according to IUPAC rules as +-3-methoxy-17-methyl-9α,13α,14α-morphinan. As the pure free base, dextromethorphan occurs as an odorless, white to slightly yellow crystalline powder. It is freely soluble in chloroform and essentially insoluble in water. Commercially, dextromethorphan is commonly available as the monohydrated hydrobromide salt, although some newer extended-release formulations contain dextromethorphan bound to an ion exchange resin based on polystyrene sulfonic acid. Dextromethorphan's specific rotation in water is +27.6° 20°C, Sodium D-line. Indications The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough caused by minor throat and bronchial irritation as commonly accompanies the common cold, as well as other causes such as inhaled irritants. Additionally, a combination of dextromethorphan and quinidine has been shown to alleviate symptoms of easy laughing and crying pseudobulbar affect in patients with amyotrophic lateral sclerosis and multiple sclerosis.3 Dextromethorphan is also being investigated as a possible treatment for neuropathic pain and pain associated with fibromyalgia.4 Pharmacokinetics At therapeutic doses, dextromethorphan acts centrally meaning that it acts on the brain as opposed to locally on the respiratory tract. It elevates the threshold for coughing, without inhibiting ciliary activity. Dextromethorphan is rapidly absorbed from the gastrointestinal tract and converted into an active metabolite, dextrorphan, within 15 to 60 minutes of ingestioncitation needed. The average dosage necessary for effective antitussive therapy is between 15 mg and 60 mg, depending on the individual. The duration of action after oral administration is approximately three to eight hours for dextromethorphan-hydrobromide, and ten to twelve hours for dextromethorphan-polistirex. Because administration of dextromethorphan can trigger a histamine release an allergic reaction, its use in atopic children is very limited. Side-effects Side-effects of dextromethorphan use can include:5 body rash/itching nausea drowsiness dizziness excitation vomiting blurred vision dilated pupils sweating fever hypertension shallow respiration diarrhea urinary retention Can also cause increases in: heart rate blood pressure body temperature Dextromethorphan can also cause other gastrointestinal disturbances. When injected directly into the blood stream, some studies suggest that dextromethorphan has the potential to cause Olney's Lesions.67 In some rare documented cases, dextromethorphan has produced psychological dependence in people who abused it. However, it does not produce physical addiction, according to the WHO Committee on Drug Dependence. Drug interactions Dextromethorphan should not be taken with either of the following: monoamine oxidase inhibitors MAOIs5 selective serotonin reuptake inhibitors SSRIs5 CNS depressant drugs and substances, including alcohol, antihistamines, and some psychotropics, will have a cumulative CNS depressant effect if taken with dextromethorphan.5 Contraindications Because dextromethorphan can trigger a histamine release allergic reaction, atopic children, who are especially susceptible to allergic reactions, should be administered dextromethorphan only if absolutely necessary, and only under the strict supervision of a health care professional.5 Clinical pharmacology Following oral administration, dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. Nervous system activity Dextromethorphan crosses the blood-brain barrier, and the following pharmacological actions have been reported: NMDA receptor antagonist σ1 and σ2 receptor agonist.8 α3β4 nicotinic receptor antagonist9 Serotonin releaser10 Dopamine reuptake inhibitor disputed511 NADPH oxidase inhibitor 12 Metabolism The first-pass through the hepatic portal vein results in some of the drug being metabolized by O-demethylation into an active metabolite of dextromethorphan called dextrorphan DXO. DXO is the 3-hydroxy derivative of dextromethorphan. The therapeutic activity of dextromethorphan is believed to be caused by both the drug and this metabolite. Dextromethorphan also undergoes N-demethylation to 3-methoxymorphinan or MEM,13 and partial conjugation with glucuronic acid and sulfate ions. Hours after dextromethorphan therapy, in humans the metabolites +-3-hydroxy-N-methylmorphinan, +-3-morphinan, and traces of the unchanged drug are detectable in the urine.5 A major metabolic catalyst involved is the cytochrome P450 enzyme known as 2D6, or CYP2D6. A significant portion of the population has a functional deficiency in this enzyme and are known as poor CYP2D6 metabolizers. O-demethylation of DXM to DXO contributes to at least 80% of the DXO formed during DXM metabolism.13 In one study on 252 Americans, 84.3% were found to be fast extensive metabolizers, 6.8% to be intermediate metabolizers, and 8.8% were slow metabolizers of DXM. 14 There are a number of known alleles for CYP2D6, including several completely inactive variants. The distribution of alleles is uneven amongst ethnic groups; see also CYP2D6 - Ethnic factors in variability. A large number of medications are potent inhibitors of CYP2D6. Some types of medications known to inhibit CYP2D6 include certain SSRI and tricyclic antidepressants, some antipsychotics, and the commonly available antihistamine diphenhydramine -- also known as Benadryl. There exists, therefore, the potential of interactions between dextromethorphan and medications which inhibit this enzyme, particularly in slow metabolizers. See also CYP2D6 - Ligands. DXM is also metabolized by CYP3A4. N-demethylation is primarily accomplished by CYP3A4, contributing to at least 90% of the MEM formed as a primary metabolite of DXM.13 A number of other CYP enzymes are implicated as minor pathways of DXM metabolism. CYP2B6 is actually more effective than CYP3A4 at N-demethylation of DXM, but since the average individual has a much lower CYP2B6 content in their liver relative to CYP3A4, most N-demethylation of DXM is catalyzed by CYP3A4.13 Brand names Dextromethorphan is an active ingredient in many brand-name cough suppressant preparations, including: Acodin Askorex Benylin BRONCORIDE-DM Buckley's Coricidin Creomulsion Delsym Daro Dexofan Dayquil Kafosed Mucinex DM Sucrets, Cough Sudafed PE Resilar Robitussin TEXCOL-DM Triaminic Tussal Tussi12 D DS Tussidex Vicks Zicam Cough Plus D History Dextromethorphan was first patented under U.S. Patent 2,676,177 . The FDA approved dextromethorphan for over-the-counter sale as a cough suppressant in 1958. This filled the need for a cough suppressant lacking the sedative side-effects, stronger potential for abuse, and physically addictive properties of codeine phosphate, the most widely-used cough medication at the time now prescription-only in the United States.15 As with most cough suppressants, studies show that dextromethorphan's effectiveness is highly debatable,16 especially in children.17 During the 1960s and 1970s, dextromethorphan became available in an over-the-counter tablet form by the brand name Romilar. In 1973, Romilar was taken off the shelves after a burst in sales due to frequent abuse, and was replaced by cough syrup in an attempt to cut down on abuse.15 More recently the early 1990s gel capsule forms began reappearing in the form of Drixoral Cough Liquid Caps and later Robitussin CoughGels as well as several generic forms of that preparation. Recreational use Main article: Non-medical use of dextromethorphan Since their introduction, over-the-counter preparations containing dextromethorphan have been used in a manner inconsistent with their labeling, often as a recreational drug.15 At doses higher than medically recommended, dextromethorphan is classified as a dissociative hallucinogenic drug, with visible effects that are similar to ketamine and phencyclidine PCP. References ^ Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration. Journal of Veterinary Pharmacology and Therapeutics. ^ DEXTROMETHORPHAN Street Names: DXM, CCC, Triple C, Skittles, Robo, Poor Man's PCP ^ Brooks B, Thisted R, Appel S, Bradley W, Olney R, Berg J, Pope L, Smith R 2004. Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial. Neurology 63 8: 1364-70. PMID 15505150. ^ Cough Drug May Help Fibromyalgia Pain. WebMD. ^ a b c d e f g Dextromethorphan. NHTSA. ^ Olney J, Labruyere J, Price M 1989. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244 4910: 1360-2. doi:10.1126/science.2660263. PMID 2660263. ^ Hargreaves R, Hill R, Iversen L. Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology. Acta Neurochir Suppl Wien 60: 15-9. PMID 7976530. ^ British Journal of Pharmacology - The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. Retrieved on 2007-07-16. ^ Hernandez SC, Bertolino M, Xiao Y, Pringle KE, Caruso FS, Kellar KJ 2000. Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors. J. Pharmacol. Exp. Ther. 293 3: 962-7. PMID 10869398. ^ Kamei J, Mori T, Igarashi H, Kasuya Y 1992. Serotonin release in nucleus of the solitary tract and its modulation by antitussive drugs. Res. Commun. Chem. Pathol. Pharmacol. 76 3: 371-4. PMID 1636059. ^ Verma A, Moghaddam B Jan 1996. NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine. Journal of Neuroscience 1: 373-9. ^ Zhang W, Wang T, Qin L, Gao HM, Wilson B, Ali SF, Zhang W, Hong JS, Liu B Jan 2004. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. The FASEB Journal. PMID 14734632. ^ a b c d Comparative Contribution to Dextromethorphan Metabolism by Cytochrome P450 Isoforms in Vitro: Can Dextromethorphan Be Used as a Dual Probe for Both CYP2D6 and CYP3A Activities?. Retrieved on 2008-08-10. ^ The polymorphic metabolism of dextromethorphan abstract. Retrieved on 2008-08-10. ^ a b c Dextromethorphan DXM | CESAR ^ Cough medicines have no benefit BBC News: Health, Tuesday, July 6, 2004. Accessed July 28, 2007. ^ 1 Kids' cough medicine no better than placebo San Francisco Chronicle, July 8, 2004 See also Morphinan parent drug of dextromethorphan Methorphan racemic mixture of dextromethorphan and levomethorphan Dextromethorphan DXM Dextrorphan DXO active compound of dextromethorphan Levomethorphan L-isomer of dextromethorphan with opioid activity Levorphanol Metabolite of levomethorphan; levorphanol is the L-isomer of dextrorphan, has opioid activity Psychedelic psychedelic experience Hallucinogen drug that produces visual alterations and is commonly used for this purpose Psychedelic Drug drug that is called 'mind expanding' and includes drugs like LSD Dissociatives drug which reduces or blocks signals to the conscious mind from other parts of the brain Ketamine compound that acts most similarly to dextrorphan Dextromethorphan DXM Dextrorphan DXO Phencyclidine PCP another compound that acts like dextromethorphan Nitrous Oxide short acting dissociative anesthetic that is inhaled for it's euphoric properties Recreational use of dextromethorphan use of dextromethorphan for purposes that induce effects similar to PCP and Ketamine v d e Dissociative hallucinogens Kappa agonists Cyclazocine - Enadoline - HZ-2 - Salvinorin A - Pentazocine - Spiradoline - Tifluadom - U-50488 NMDA receptor antagonists 2-MDP - Aptiganel - Dexoxadrol - Dextromethorphan - Dizocilpine - Esketamine - Etoxadrol - FPL-12495 - Gacyclidine - Ketamine - Memantine - PCE - PCP - Remacemide - PCPy - Selfotel - TCP - Tiletamine Others Efavirenz - Muscimol - Nitrous oxide - Xenon v d e Opioids N02A Opium derivatives Whole Opium Preparations Diascordium Dover's Powder Granulated Opium Laudanum Mithridate Opium Paregoric Poppy Straw Concentrate Poppy tea Powdered Opium Raw Opium Smoking Opium Theriac Natural Opiates Opium Alkaloids see also: Components of Opium 16-Hydroxythebaine Allocryptopine Berberine Bulbocapnine Canadine Codamine Codeine Coptisine Coreximine Corytuberine Cotarnine Cryptopine Cycloartenol Cycloartenone Cyclolaudenol Dehydroreticuline Dihydrosanguinarine Eupaverine Glaucine Hydrocotarnine Isoboldine Isocorypalmine Laudanidine Laudanine Laudanosine Magnoflorine Morphine Narceine Narceinone Narcotine Narcotoline Neopine Norlaudanosoline Norsanguinarine Noscapine Oripavine Oxysanguinarine Palaudine Papaverine Papaveraldine Papaverrubine B O-Methyl-Porphyroxine Papaverrubine C Epiporphyroxine Papaverrubine D Porphyroxine Perparin Pseudomorphine Reticuline Salutaridine Sinoacutine Sanguinarine Scoulerine Somniferine Stepholidine Thebaine Alkaloid Salts Mixtures Omnopon Pantopon Papaveretum Tetrapon Semisynthetics Morphine Family 14-hydroxydihydromorphine Hydromorphinol 2,4-Dinitrophenylmorphine 6-Methyldihydromorphine 6-Methylenedihydrodesoxymorphine Apomorphine Desomorphine Diacetyldihydromorphine Dihydrodesoxymorphine Dihydroheroin Dihydromorphine Dipropanoylmorphine Ethyldihydromorphine Heroin Diamorphine Heroin-7,8-Oxide Methyldesorphine Methyldihydromorphine Nicomorphine N-Phenethylnormorphine Codeine-Dionine Family Acetylcodeine Benzylmorphine Codeine Desocodeine Dihydroheterocodeine Ethylmorphine Dionine Heterocodeine Isocodeine Morpholinylethylmorphine Pholcodine Myrophine Nalodeine Morphinones 14-Ethoxymetopon 14-Methoxymetopon 14-O-Methyloxymorphone 14-Phenylpropoxymetopon 14-Hydroxydihydromorphinone Oxymorphone 7-Spiroindanyloxymorphone 8,14-Dihydroxydihydromorphinone Acetylmorphone Ethyldihydromorphinone Hydromorphinol Hydromorphinone Hydromorphone Hydroxycodeine Methyldihydromorphinone Metopon Morphinol Morphinone N-Phenethyl-14-ethoxymetopon Oxymorphone Semorphone Codeinones 1-carboxy-14-hydroxydihydrocodeinone 1-carbethoxy-14-hydroxydihydrocodeinone 14-Hydroxydihydrocodeinone Oxycodone Acetyldihydrocodeinone Codeinone Codorphone Codoxime Dihydrocodeinone enol acetate Dihydrohydroxycodeinone Hydrocodone Oxycodone Thebacon Dihydrocodeine Series 14-hydroxydihydrocodeine Acetyldihydrocodeine Dihydrocodeine Dihydrodesoxycodeine/Desocodeine Dihydroisocodeine Nicocodeine Nicodicodeine Nitrogen Morphine Derivatives Codeine-N-Oxide Heroin-N-Oxide Hydromorphone-N-Oxide Morphine-N-Oxide Others α-chlorocodide Azidomorphine Chloromorphide Hydromorphazone Morphazone Oxymorphazone Pholcodine Active Opiate Metabolites Codeine-N-Oxide Genocodeine Hydromorphone-N-Oxide Heroin-7,8-Oxide Morphine-3-glucuronide Morphine-6-glucuronide Monoacetylmorphine Morphine-N-Oxide Genomorphine Naltrexol Norcodeine Normorphine Morphinans Morphinan Series 4-chlorophenylpyridomorphinan Cyclorphan Dextro-3-hydroxy-N-allylmorphinan Dextromethorphan Dextrorphan Dimemorfan Levargorphan Levallorphan Levorphanol Levorphan Levophenacylmorphan Levomethorphan Norlevorphanol N-Methylmorphinan Oxilorphan Phenomorphan Racemethorphan Racemorphan Stephodeline Xorphanol Others 5,6-Dihydronorsalutaridine 6-Ketonalbuphine Aknadinine Butorphanol Cyprodime Drotebanol Fenfangjine G Nalbuphine Sinococuline Sinomenine Cocculine Benzomorphans 5,9-DEHB Allylnormetazocine Anazocine Bremazocine Cogazocine Cyclazocine Dezocine Eptazocine Etazocine Ethylketocyclazocine Fluorophen Ketazocine Metazocine Pentazocine Phenazocine Quadazocine Thiazocine 4-Phenylpiperidines Pethidines Meperidines Allylnorpethidine Anileridine Benzethidine Carperidine Difenoxin Diphenoxylate Etoxeridine Carbetidine Furethidine Hydroxypethidine Bemidone Hydroxymethoxypethidine Morpheridine Oxpheneridine Carbamethidine Meperidine-N-Oxide Pethidine Meperidine Pethidine Intermediate A Pethidine Intermediate B Norpethidine Pethidine Intermediate C Pethidinic Acid Pheneridine Phenoperidine Piminodine Properidine Ipropethidine Sameridine Prodines Allylprodine α-meprodine α-prodine β-meprodine β-prodine Isopromedol Meprodine MPPP PEPAP Prodine Prosidol Trimeperidine Promedol Ketobemidones Acetoxyketobemidone Droxypropine Ketobemidone Methylketobemidone Propylketobemidone Others Alvimopan Loperamide Picenadol Open Chain Opioids Amidones Dextromethadone Dextroisomethadone Dipipanone Hexalgon Norpipanone Isomethadone Levoisomethadone Levomethadone Methadone Methadone intermediate Normethadone Norpipanone Phenadoxone Heptazone Pipidone Methadols Acetylmethadol α-methadol α-acetylmethadol β-methadol β-acetylmethadol Dimepheptanol Racemethadol Levo-α-acetylmethadol Noracymethadol Moramides Dextromoramide Levomoramide Moramide intermediate Racemoramide Thiambutenes Diethylthiambutene Dimethylthiambutene Ethylmethylthiambutene Piperidylthiambutene Pyrrolidinylthiambutene Thiambutene Tipepidine Phenalkoxams Dextropropoxyphene Dimenoxadol Dioxaphetyl Butyrate Levopropoxyphene Propoxyphene Ampromides Diampromide Phenampromide Propiram Others IC-26 Isoaminile Lefetamine R-4066 Anilidopiperidines 3-Allylfentanyl 3-Methylfentanyl 3-Methylthiofentanyl Alfentanil α-methylacetylfentanyl α-methylfentanyl α-methylthiofentanyl Benzylfentanyl β-hydroxyfentanyl β-hydroxythiofentanyl β-methylfentanyl Brifentanil Carfentanil Fentanyl Lofentanil Mirfentanil Ohmefentanyl Parafluorofentanyl Phenaridine Remifentanil Sufentanil Thenylfentanyl Thiofentanyl Trefentanil Oripavine derivatives 7-PET Acetorphine Alletorphine BU-48 Buprenorphine Butorphine Cyprenorphine Dihydroetorphine Diprenorphine Etorphine N-cyclopropylmethyl-noretorphine Nepenthone Norbuprenorphine Thevinone Thienorphine Phenazepines Ethoheptazine Meptazinol Metheptazine Metethoheptazine Proheptazine Pirinitramides Bezitramide Piritramide Benzimidazoles Clonitazene Etonitazene Nitazine Indoles 7-Acetoxymitragynine 7-Hydroxymitragynine Akuammidine Akuammine Eseroline Hodgkinsine Ibogaine Mitragynine Pericine ψ-Akuammigine Diphenylmethylpiperazines BW373U86 DPI-221 DPI-287 DPI-3290 SNC-80 Opioid Peptides Casomorphin DADLE DALDA DAMGO Dermenkephalin Dermorphin Deltorphin DPDPE Dynorphin Endomorphin Endorphin Enkephalin Gliadorphin Morphiceptin Nociceptin Octreotide Opiorphin Rubiscolin TRIMU 5 Others 4-p-Bromophenyl-4-dimethylamino-1-phenethylcyclohexanol Azaprocin Bisnortilidine C-8813 Ciramadol Cyclohexyloxy-α-phenethylamine Enadoline Faxeladol Herkinorin JTC-801 Methopholine NNC 63-0532 Nortilidine O-Desmethyltramadol Prodilidine Salvinorin A SC-17599 RWJ-394,674 Tapentadol Tifluadom Tilidine Tramadol Viminol W-18 Zipeprol Opioid Antagonists 5'-Guanidinonaltrindole β-Funaltrexamine 6β-Naltrexol Amiphenazole Binaltorphimine Clocinnamox Cyclazocine Cyprodime Diprenorphine Fedotozine M5050 Levallorphan Methocinnamox Methylnaltrexone Nalfurafine Nalmefene Nalmexone Naloxazone Naloxonazine Naloxone Naloxone benzoylhydrazone Nalorphine Naltrexone Naltrindole Norbinaltorphimine Oxilorphan v d e Cough and cold preparations R05 Expectorants Tyloxapol - Potassium iodide - Guaifenesin - Ipecacuanha - Althea root - Senega - Antimony pentasulfide - Creosote - Guaiacolsulfonate - Levoverbenone Mucolytics Acetylcysteine - Bromhexine - Carbocisteine - Eprazinone - Mesna - Ambroxol - Sobrerol - Domiodol - Letosteine - Stepronin - Tiopronin - Dornase alfa - Neltenexine - Erdosteine Cough suppressants: Opium alkaloids, Opioids, and derivatives Acetyldihydrocodeine - Benzylmorphine - Codeine - Dextromethorphan - Heroin - Dihydrocodeine - Dimemorfan - Ethylmorphine - Hydrocodone - Hydromorphone - Isoaminile - Laudanum - Levomethadone - Levopropoxyphene - Methadone - Nicocodeine - Nicodicodeine - Normethadone - Noscapine - Pholcodine - Thebacon - Tipepidine - Zipeprol Other cough suppressants Benzonatate - Benproperine - Bibenzonium bromide - Butamirate - Clobutinol - Clofedanol - Cloperastine - Diphenhydramine - Dibunate - Dimethoxanate - Droxypropine - Dropropizine - Fedrilate - Glaucine - Levodropropizine - Meprotixol - Morclofone - Nepinalone - Oxolamine - Oxeladin - Pentoxyverine - Pipazetate - Prenoxdiazine - Piperidione Retrieved from http://en..org/wiki/Dextromethorphan Categories: Opioids | Analgesics | Antitussives | Dissociatives | Dopamine reuptake inhibitors | Morphinans | NMDA receptor antagonists | Sigma agonistsHidden categories: All articles with statements | Articles with statements since July 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Eesti Español Français Magyar Nederlands 日本語 Polski РуÑ?Ñ?кий Suomi Svenska ä¸æ–‡ This page was last modified on 16 August 2008, at 19:34
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.